Organism : Bacillus subtilis | Module List :
BSU29420 fabG

3-ketoacyl-(acyl-carrier-protein) reductase (RefSeq)

CircVis
Functional Annotations (6)
Function System
Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) cog/ cog
3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity go/ molecular_function
metabolic process go/ biological_process
Fatty acid biosynthesis kegg/ kegg pathway
Biosynthesis of unsaturated fatty acids kegg/ kegg pathway
Metabolic pathways kegg/ kegg pathway
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BSU29420
(Mouseover regulator name to see its description)

BSU29420 is regulated by 25 influences and regulates 0 modules.
Regulators for BSU29420 fabG (25)
Regulator Module Operator
BSU01010 296 tf
BSU02680 296 tf
BSU04680 296 tf
BSU04730 296 tf
BSU09690 296 tf
BSU09990 296 tf
BSU21020 296 tf
BSU24770 296 tf
BSU33080 296 tf
BSU33740 296 tf
BSU36020 296 tf
BSU37650 296 tf
BSU38600 296 tf
BSU03620 252 tf
BSU04680 252 tf
BSU04730 252 tf
BSU19100 252 tf
BSU19200 252 tf
BSU26580 252 tf
BSU28820 252 tf
BSU29630 252 tf
BSU36020 252 tf
BSU38220 252 tf
BSU40350 252 tf
BSU40710 252 tf

Warning: BSU29420 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
5444 3.30e-02 cCTCcTtCctc
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5445 4.30e+01 TtttTacagcaagcTtTtttg
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5530 4.30e-05 CtCctTTTtc
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5531 6.30e-01 GGAGGtat
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BSU29420

BSU29420 is enriched for 6 functions in 3 categories.
Module neighborhood information for BSU29420

BSU29420 has total of 44 gene neighbors in modules 252, 296
Gene neighbors (44)
Gene Common Name Description Module membership
BSU01540 salA Mrp family regulator (RefSeq) 113, 296
BSU03450 hxlB 6-phospho-3-hexuloisomerase (PHI) (RefSeq) 64, 296
BSU03460 hxlA 3-hexulose-6-phosphate synthase (HPS) (RefSeq) 64, 296
BSU03470 hxlR positive regulator of hxlAB expression (RefSeq) 91, 296
BSU04040 ycsE putative phosphatase (RefSeq) 247, 252
BSU08210 malQ maltose and maltodextrin ABC transporter subunit (ATP-binding protein) (RefSeq) 123, 296
BSU08220 yfiC putative ABC transporter (ATP-binding protein) (RefSeq) 113, 296
BSU09240 yhcW putative phosphoglycolate phosphatase (RefSeq) 113, 252
BSU09310 pgcA alpha-phosphoglucomutase (RefSeq) 113, 252
BSU09690 nhaX stress response protein, UspA family (RefSeq) 137, 296
BSU10200 yhfE putative endoglucanase (RefSeq) 101, 296
BSU10240 yhfI putative metal-dependent hydrolase (RefSeq) 113, 252
BSU10250 yhfJ putative lipoate-protein ligase (RefSeq) 113, 252
BSU10260 yhfK putative epimerase (RefSeq) 252, 412
BSU10320 yhfP putative oxidoreductase (RefSeq) 29, 252
BSU11840 yjcF putative acetyltransferase (RefSeq) 101, 296
BSU11850 yjcG hypothetical protein (RefSeq) 101, 296
BSU11860 yjcH putative hydrolase (RefSeq) 101, 296
BSU12230 hemD uroporphyrinogen-III synthase (RefSeq) 187, 252
BSU14450 ampS aminopeptidase (RefSeq) 113, 252
BSU14820 ylaL hypothetical protein (RefSeq) 70, 296
BSU15040 ylbK putative hydrolase (RefSeq) 113, 252
BSU16860 ymfH putative processing protease (RefSeq) 68, 252
BSU19150 yocB hypothetical protein (RefSeq) 203, 296
BSU24870 glpG membrane endopeptidase (RefSeq) 187, 252
BSU28820 ysdC putative endo-1,4-beta-glucanase (RefSeq) 247, 252
BSU29410 ytkL metal-dependent hydrolase (RefSeq) 68, 296
BSU29420 fabG 3-ketoacyl-(acyl-carrier-protein) reductase (RefSeq) 252, 296
BSU29760 ytxJ hypothetical protein (RefSeq) 296, 320
BSU29770 ytxH hypothetical protein (RefSeq) 296, 320
BSU29780 ytxG hypothetical protein (RefSeq) 296, 320
BSU31770 yueI hypothetical protein (RefSeq) 160, 252
BSU31910 yukE hypothetical protein (RefSeq) 31, 296
BSU32360 yunC putative RNA binding protein (RefSeq) 243, 252
BSU32370 yunD putative nuclease/nucleotidase/phosphoesterase (RefSeq) 68, 252
BSU32380 yunE putative integral inner membrane protein (RefSeq) 68, 252
BSU32390 yunF hypothetical protein (RefSeq) 68, 252
BSU32400 yunG hypothetical protein (RefSeq) 68, 252
BSU32810 yusI putative oxidoreductase with thioredoxin domain (RefSeq) 113, 252
BSU32990 mrgA metalloregulation DNA-binding stress protein (RefSeq) 296, 359
BSU33850 yvbG putative integral inner membrane protein (RefSeq) 167, 296
BSU35310 yvyD ribosome-associated sigma 54 modulation protein (RefSeq) 296, 381
BSU40040 glxK glycerate kinase (RefSeq) 68, 296
BSU40190 fbp fructose-1,6-bisphosphatase (RefSeq) 160, 252
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BSU29420
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend