Organism : Clostridium acetobutylicum | Module List :
Uncharacterized conserved protein, VanW of Enterococcus faecalis related (NCBI ptt file)
Functional Annotations (1)
|Uncharacterized vancomycin resistance protein||cog/ cog|
Regulation information for CAC0691(Mouseover regulator name to see its description)
Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
|Motif Id||e-value||Consensus||Motif Logo|
Functional Enrichment for CAC0691
|Uncharacterized vancomycin resistance protein||cog/ cog|
Module neighborhood information for CAC0691
|Gene||Common Name||Description||Module membership|
|CAC0013||CAC0013||Uncharacterized small conserved protein, ortholog of T.maritima (4981999) and P.abyssi (5457704) (NCBI ptt file)||59, 253|
|CAC0022||asd||Aspartate-semialdehyde dehydrogenase (NCBI ptt file)||176, 231|
|CAC0067||CAC0067||(FS) similar to ABC transporter (permease), YXDM B.subtilis ortholog (NCBI ptt file)||176, 246|
|CAC0069||CAC0069||Predicted iron-binding protein, hemerythrin (NCBI ptt file)||212, 253|
|CAC0130||CAC0130||Uncharacterized membrane protein, YTAF B.subtilis ortholog (NCBI ptt file)||176, 341|
|CAC0317||CAC0317||Sensory transduction histidine kinase (NCBI ptt file)||137, 253|
|CAC0481||nrdG||Anaerobic ribonucleoside-triphosphate reductase activating protein, gene nrdG (NCBI ptt file)||163, 253|
|CAC0495||thiC||Thiamine monophosphate syntase (NCBI ptt file)||90, 253|
|CAC0550||CAC0550||Possible sigma factor (NCBI ptt file)||176, 253|
|CAC0691||CAC0691||Uncharacterized conserved protein, VanW of Enterococcus faecalis related (NCBI ptt file)||176, 253|
|CAC0693||CAC0693||Transcriptional regulator of the LacI family (NCBI ptt file)||176, 238|
|CAC0773||CAC0773||ABC-type cobalt transport protein ATPase component (NCBI ptt file)||28, 253|
|CAC0777||CAC0777||Acetyltransferase (the isoleucine patch superfamily) (NCBI ptt file)||176, 306|
|CAC0816||CAC0816||Lipase-esterase related protein (NCBI ptt file)||176, 209|
|CAC0875||CAC0875||Predicted permease (NCBI ptt file)||206, 253|
|CAC1045||CAC1045||Predicted permease (NCBI ptt file)||80, 176|
|CAC1048||CAC1048||Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily (NCBI ptt file)||4, 253|
|CAC1061||CAC1061||Uncharcterized protein, shares conserved domain among different RHS family proteins and WAPA of B.subtilis (NCBI ptt file)||183, 253|
|CAC1068||CAC1068||Hypothetical protein, CF-25 family (NCBI ptt file)||176, 267|
|CAC1112||CAC1112||Hypothetical protein, CF-11 family (NCBI ptt file)||104, 253|
|CAC1117||CAC1117||Hypothetical protein (NCBI ptt file)||195, 253|
|CAC1119||CAC1119||Hypothetical protein (NCBI ptt file)||187, 253|
|CAC1174||CAC1174||Hypothetical protein (NCBI ptt file)||104, 253|
|CAC1175||CAC1175||Hypothetical protein, CF-35 family (NCBI ptt file)||104, 253|
|CAC1190||CAC1190||Predicted Fe-S-cluster redox enzyme, YLON B.subtilis homolog (NCBI ptt file)||187, 253|
|CAC1192||CAC1192||Phage replicative DNA helicase, YorI B.subtilis homolog (NCBI ptt file)||187, 253|
|CAC1193||CAC1193||Hypothetical protein (NCBI ptt file)||104, 253|
|CAC1194||CAC1194||Hypothetical protein (NCBI ptt file)||137, 253|
|CAC1209||nrdD||Anaerobic ribonucleotide reductase (NCBI ptt file)||187, 253|
|CAC1215||CAC1215||Hypothetical protein (NCBI ptt file)||4, 176|
|CAC1312||CAC1312||Hypothetical protein (NCBI ptt file)||109, 176|
|CAC1434||CAC1434||Alkaline phosphatase superfamily protein (NCBI ptt file)||176, 276|
|CAC1519||CAC1519||Predicted permease (NCBI ptt file)||253, 357|
|CAC1554||CAC1554||Heavy-metal-associated domain (N-terminus) and membrane-bounded cytochrome biogenesis cycZ-like domain, possible membrane copper tolerance protein (NCBI ptt file)||176, 206|
|CAC1984||CAC1984||Predicted permease (NCBI ptt file)||176, 183|
|CAC2069||CAC2069||Hypothetical protein (NCBI ptt file)||152, 176|
|CAC2369||CAC2369||Hypothetical protein (NCBI ptt file)||253, 254|
|CAC2396||CAC2396||Predicted xylanase/chitin deacetylase (NCBI ptt file)||179, 253|
|CAC2505||CAC2505||Uncharacterized membrane protein, YXJN B.subtilis homolog (NCBI ptt file)||134, 176|
|CAC2751||CAC2751||Predicted acetyltransferase (NCBI ptt file)||176, 253|
|CAC2755||CAC2755||MDR-type ABC transporter (membrane associated ATPase) (NCBI ptt file)||140, 176|
|CAC2756||CAC2756||MDR-type ABC transporter (membrane associated ATPase) (NCBI ptt file)||102, 176|
|CAC2765||CAC2765||Similar to uncharacterized domain of sensory transducer protein (NCBI ptt file)||176, 309|
|CAC3360||CAC3360||Transcriptional regulator, LysR family (NCBI ptt file)||176, 277|
|CAC3386||CAC3386||Hypothetical protein (NCBI ptt file)||132, 176|
|CAC3414||CAC3414||ABC-type multidrug/protein/lipid transport system, ATPase component (NCBI ptt file)||176, 253|
|CAC3437||CAC3437||Predicted membrane-associated Zn-dependent protease, HtpX family (BlaR subfamily) (NCBI ptt file)||59, 253|
|CAC3600||dapA||Dihydrodipicolinate synthase (NCBI ptt file)||176, 277|
Gene Page Help
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
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Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
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Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
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CircVisOur circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
- 2. Source gene
- 3. Target genes (other module members)
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- 5. Module(s) that source gene and target genes belong to
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