Organism : Clostridium acetobutylicum | Module List :
Putative intracellular protease/amidase (ThiJ family) (NCBI ptt file)
Functional Annotations (1)
|Putative intracellular protease/amidase||cog/ cog|
Regulation information for CAC3350(Mouseover regulator name to see its description)
Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
|Motif Id||e-value||Consensus||Motif Logo|
Functional Enrichment for CAC3350
|Putative intracellular protease/amidase||cog/ cog|
Module neighborhood information for CAC3350
|Gene||Common Name||Description||Module membership|
|CAC0335||CAC0335||Hypothetical protein, CF-7 family (NCBI ptt file)||65, 230|
|CAC0511||CAC0511||Predicted P-loop containing kinase, similar to B.subtilis yvcJ (NCBI ptt file)||102, 291|
|CAC0524||CAC0524||Response regulator (CheY-like and HTH domains) (NCBI ptt file)||154, 230|
|CAC0526||CAC0526||ABC transporter, ATPase component (NCBI ptt file)||154, 230|
|CAC0535||CAC0535||Metal-dependent hydrolase of the beta-lactamase superfamily II (NCBI ptt file)||47, 291|
|CAC0590||ribD||Riboflavin biosynthesis protein RIBD (pirimidine deaminase and pirimidine reductase) (NCBI ptt file)||266, 291|
|CAC0591||ribB||Riboflavin synthase alpha chain (NCBI ptt file)||221, 291|
|CAC0592||ribA||Riboflavin biosynthes protein RIBA (GTPcyclohydrolase/3,4-dihydroxy-2-butanone 4-phosphate synthase) (NCBI ptt file)||221, 291|
|CAC0593||ribH||Riboflavin synthase beta-chain (NCBI ptt file)||221, 291|
|CAC0595||CAC0595||Glutamine amidotranspherase (possibly involved in histidine and purine biosinthesis) (NCBI ptt file)||83, 291|
|CAC0596||gerKA||Spore germination protein. gerKA (NCBI ptt file)||230, 265|
|CAC0599||CAC0599||Transcriptional regulator, GntR family (NCBI ptt file)||223, 291|
|CAC0717||CAC0717||Predicted membrane protein (NCBI ptt file)||154, 230|
|CAC0749||CAC0749||HD hydrolase superfamily protein (NCBI ptt file)||154, 291|
|CAC1004||CAC1004||Predicted membrane protein (NCBI ptt file)||154, 230|
|CAC1095||CAC1095||Uncharacterized protein, YjiN homolog (NCBI ptt file)||30, 230|
|CAC1636||CAC1636||Uncharacterized protein, homolog of B. firmus (2654481) (NCBI ptt file)||291, 349|
|CAC1638||CAC1638||Hypothetical protein, CF-37 family(almost identical) (NCBI ptt file)||291, 349|
|CAC1639||CAC1639||Hypothetical protein, CF-7 family (NCBI ptt file)||291, 349|
|CAC1640||CAC1640||Uncharacterized protein, YQCG B.subtilis homolog; CF-7 family (NCBI ptt file)||291, 349|
|CAC1671||CAC1671||Predicted ATPase related to the helicase subunit of the Holliday junction resolvase (NCBI ptt file)||291, 326|
|CAC1672||CAC1672||Rad3-related DNA helicase (NCBI ptt file)||291, 326|
|CAC1966||CAC1966||Surface-layer related glycoprotein (NCBI ptt file)||70, 291|
|CAC1969||CAC1969||Possible plasmid transfer factor, TraK (NCBI ptt file)||287, 291|
|CAC2541||CAC2541||Reductase/isomerase/elongation factor common domain (NCBI ptt file)||70, 291|
|CAC2544||etfB||Electron-transferring flavoprotein small subunit (NCBI ptt file)||41, 291|
|CAC2606||CAC2606||Predicted sugar-phosphate isomerase (NCBI ptt file)||177, 230|
|CAC2607||CAC2607||Short-chain alcohol dehydrogenase family protein (NCBI ptt file)||154, 230|
|CAC2737||sbcD||DNA repair exonuclease (NCBI ptt file)||154, 230|
|CAC2763||CAC2763||Membrane assosiated methyl-accepting chemotaxis protein with HAMP domain (NCBI ptt file)||154, 230|
|CAC2825||CAC2825||Uncharacterized conserved protein, YQXD B.subtilis ortholog (NCBI ptt file)||154, 230|
|CAC2997||CAC2997||Uracil-DNA glycosylase (NCBI ptt file)||108, 230|
|CAC3268||CAC3268||Uncharacterized conserved membrane protein, possible MDR-type transporter (NCBI ptt file)||220, 230|
|CAC3269||CAC3269||ABC-type MDR transport system, ATPase component (NCBI ptt file)||144, 230|
|CAC3302||gerKC||Spore germination protein GerKC, membrane protein (NCBI ptt file)||154, 230|
|CAC3350||CAC3350||Putative intracellular protease/amidase (ThiJ family) (NCBI ptt file)||230, 291|
|CAC3501||CAC3501||Predicted phosphosugar isomerase (NCBI ptt file)||108, 230|
|CAC3505||CAC3505||Multimeric flavodoxin WrbA family protein (NCBI ptt file)||212, 291|
|CAC3515||CAC3515||Alpha/beta superfamily hydrolase (possible peptidase) (NCBI ptt file)||43, 230|
|CAC3576||CAC3576||Dioxygenase related to 2-nitropropane dioxygenase (NCBI ptt file)||6, 291|
|CAC3656||CAC3656||Uncharacterized conserved protein, yaiN/yohL family (NCBI ptt file)||185, 291|
Gene Page Help
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
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Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.
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Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.
Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
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CircVisOur circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
- 2. Source gene
- 3. Target genes (other module members)
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