Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 211 - 220 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_222	18 CD630_22450 - asnC Type: Gene Product:Asparaginyl-tRNA synthetase (Asparagine--tRNAligase) (AsnRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_26180 - ileS Type: Gene Product:Isoleucyl-tRNA synthetase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_12840 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_20340 - argC Type: Gene Product:N-acetyl-gamma-glutamyl-phosphate reductase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_07500 - Type: Gene Product:ABC-type transport system, aminoacid-familyextracellular solute-binding protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_17850 - argG Type: Gene Product:Argininosuccinate synthase (Citrulline--aspartateligase) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_21180 - thrC Type: Gene Product:Threonine synthase \| Pathway: \| COG: Amino acid transport and metabolism CD630_07510 - Type: Gene Product:ABC-type transport system, aminoacid-familypermease \| Pathway: \| COG: Amino acid transport and metabolism CD630_20320 - argB Type: Gene Product:Acetylglutamate kinase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_12860 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_20330 - argJ Type: Gene Product:Arginine biosynthesis bifunctional protein ArgJ[Includes: Glutamate N-acetyltransferase ; Amino-acidacetyltransferase] \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_21190 - thrB Type: Gene Product:Homoserine kinase (HSK) (HK) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_12830 - Type: Gene Product:Conserved hypothetical protein, UPF0297 family \| Pathway: \| COG: Function unknown CD630_12820 - alaS Type: Gene Product:Alanyl-tRNA synthetase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_20310 - argM Type: Gene Product:Succinylornithine transaminase (ACOAT) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_12850 - Type: Gene Product:Putative Holliday junction resolvase \| Pathway: \| COG: Replication, recombination and repair CD630_07520 - Type: Gene Product:ABC-type transport system, aminoacid-familyATP-binding protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_20300 - argF Type: Gene Product:Ornithine carbamoyltransferase (OTCase) \| Pathway: \| COG: Amino acid transport and metabolism	4.6e-16	0.0000006	0.51	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_33530 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_403	22 CD630_16970 - ribH Type: Gene Product:6,7-dimethyl-8-ribityllumazine synthase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_24990 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_14780 - feoA Type: Gene Product:Ferrous iron transport protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_14800 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_16490 - Type: Gene Product:ABC-type transport system, iron-familyATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_16990 - ribE Type: Gene Product:Riboflavin synthase alpha subunit \| Pathway: \| COG: Coenzyme transport and metabolism CD630_28941 - Type: Gene Product:Putative holin \| Pathway: \| COG: Function unknown CD630_28940 - Type: Gene Product:Putative cell wall hydrolase/autolysin \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_31340 - Type: Gene Product:PTS system, fructose-like IIABC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_19990 - fldX Type: Gene Product:Flavodoxin \| Pathway: \| COG: Energy production and conversion CD630_16470 - Type: Gene Product:ABC-type transport system, iron-family permease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_33871 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf25 \| Pathway: \| COG: Function unknown CD630_33870 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf24 \| Pathway: \| COG: Function unknown CD630_17000 - ribD Type: Gene Product:Riboflavin biosynthesis protein ribD [Includes:Diaminohydroxyphosphoribosylaminopyrimidine deaminase ;5-amino-6-(5-phosphoribosylamino)uracil reductase] \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_14790 - feoB1 Type: Gene Product:Ferrous iron transport protein B \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_16480 - Type: Gene Product:ABC-type transport system, iron-family permease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_31350 - Type: Gene Product:Putative fructose-1-6-bisphosphate aldolase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_16980 - ribBA Type: Gene Product:Riboflavin biosynthesis protein ribBA [Includes:3,4-dihydroxy-2-butanone 4-phosphate synthase; GTPcyclohydrolase-2] \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_28950 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_16500 - Type: Gene Product:ABC-type transport system, iron-familyextracellular substrate-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_28930 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_14770 - feoA Type: Gene Product:Ferrous iron transport protein \| Pathway: \| COG: Inorganic ion transport and metabolism	0.000013	`NA`	0.51	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_22140 - SinR Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_39	22 CD630_36360 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_36361 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_04790 - spaE Type: Gene Product:ABC-type transport system,lantibiotic/multidrug-family permease \| Pathway: \| COG: Function unknown CD630_22990 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_11261 - Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_27130 - ldtcd2 Type: Gene Product:L,D-transpeptidases \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_04850 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_27150 - gtaB Type: Gene Product:UTP--glucose-1-phosphate uridylyltransferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_04620 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_04810 - spaR Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_04640 - Type: Gene Product:Putative beta-lactamase-like hydrolase \| Pathway: \| COG: Function unknown CD630_36350 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_36370 - Type: Gene Product:Putative NADPH-dependent FMN reductase \| Pathway: \| COG: Function unknown CD630_11270 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_04780 - spaF Type: Gene Product:ABC-type transport system,lantibiotic/multidrug-family ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_36380 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_27140 - galE Type: Gene Product:UDP-glucose 4-epimerase \| Pathway: Carbohydrate metabolism \| COG: Cell wall/membrane/envelope biogenesis CD630_04630 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_04800 - spaG Type: Gene Product:ABC-type transport system,lantibiotic/multidrug-family permease \| Pathway: \| COG: Function unknown CD630_04860 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_04820 - spaK Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_04610 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms	0.5	`NA`	0.51	Inferelator: 2 Hypergeometric: 2 TF Influences from Inferelator CD630_01710 - rex Type: Gene Product:Transcriptional regulator, Redox-sensingrepressor Rex \| Pathway: \| COG: Transcription CD630_02760 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_07720 - sigF Type: Gene Product:RNA polymerase sigma-F factor \| Pathway: \| COG: Transcription CD630_26430 - sigE Type: Gene Product:RNA polymerase sigma-E factor \| Pathway: \| COG: Transcription
Module_175	12 CD630_19904 - Type: Gene Product:Fragment of conserved hypothetical protein \| Pathway: \| COG: CD630_21710 - Type: Gene Product:Fragment of putative sodium:dicarboxylatesymporter (Part 2) \| Pathway: \| COG: Energy production and conversion, Energy production and conversion CD630_05102 - Type: Gene Product:Fragment of putative conjugative transposonprotein Tn5397, CTn3-Orf5 (C-terminal region) \| Pathway: \| COG: CD630_23011 - Type: Gene Product:Fragment of putative phage protein (C-terminalregion) \| Pathway: \| COG: CD630_09030 - Type: Gene Product:Fragment of putative oxydoreductase (Part 1) \| Pathway: \| COG: Energy production and conversion, Energy production and conversion CD630_33580 - Type: Gene Product:Fragment of C-terminal transcriptional regulator,AsnC/Lrp family \| Pathway: \| COG: Transcription CD630_14370 - Type: Gene Product:Fragment of transcriptional regulator,sigma-54-dependent (N-terminal region) \| Pathway: \| COG: Transcription CD630_33810 - Type: Gene Product:Fragment of putative membrane protein Tn916-like,CTn7-orf17 (Part 2) \| Pathway: \| COG: Function unknown, Function unknown CD630_08080 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_06780 - Type: Gene Product:Fragment of conserved hypothetical protein(C-terminal region) \| Pathway: \| COG: CD630_22840 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_17452 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	`NA`	`NA`	0.51	Inferelator: 0 Hypergeometric: 0 TF Influences from Inferelator `No TF influences from Inferelator` TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_24	20 CD630_19840 - Type: Gene Product:Putative hydrolase, NUDIX family \| Pathway: \| COG: Replication, recombination and repair CD630_30850 - mngB Type: Gene Product:Alpha-mannosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_05820 - Type: Gene Product:Putative pyruvate phosphate dikinase,PEP/pyruvate-binding \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_30320 - Type: Gene Product:Putative pyridoxal phosphate-dependenttransferase \| Pathway: \| COG: Amino acid transport and metabolism CD630_03020 - rbsC Type: Gene Product:ABC-type transport system, ribose-specificpermease \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_02990 - rbsK Type: Gene Product:Ribokinase, pfkB family \| Pathway: Carbohydrate metabolism \| COG: Carbohydrate transport and metabolism CD630_31650 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Replication, recombination and repair CD630_31670 - Type: Gene Product:Putative phosphatidylethanolamine-bindingregulatory protein \| Pathway: \| COG: Function unknown CD630_03030 - argE Type: Gene Product:Acetylornithine deacetylase ArgE \| Pathway: \| COG: Amino acid transport and metabolism CD630_03000 - rbsB Type: Gene Product:ABC-type transport system, ribose-specificextracellular solute-binding protein \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_05890 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_30870 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription CD630_t0450 - tRNA-Val Type: Gene Product: \| Pathway: \| COG: CD630_30860 - mngA Type: Gene Product:PTS system, 2-O-a-mannosyl-D-glycerate-specificIIABC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_03010 - rbsA Type: Gene Product:ABC-type transport system, ribose-specificATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_05810 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_03040 - Type: Gene Product:Conserved hypothetical protein, DUF1355 family \| Pathway: \| COG: Function unknown CD630_05900 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_23861 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_02980 - rbsR Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription	0.000009	`NA`	0.51	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_02980 - rbsR Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription CD630_30870 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_357	5 CD630_24170 - Type: Gene Product:PTS system, Sorbitol-like IIB component(Glucitol) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_19910 - Type: Gene Product:Fragment of integrase (C-terminal region) \| Pathway: \| COG: Replication, recombination and repair CD630_13760 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_21900 - Type: Gene Product:Cyclomaltodextrinase (maltogenic alpha-amylase)(cyclomaltodextrin dextrin-hydrolase (decyclizing)) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_16560 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown	2.1	`NA`	0.51	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_31750 - cggR Type: Gene Product:Transcriptional regulator, SorC family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_108	11 CD630_05240 - Type: Gene Product:Putative peptidase, M20 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_17151 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_08660 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_18990 - Type: Gene Product:Putative dCMP deaminase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_15960 - map2 Type: Gene Product:Methionine aminopeptidase Map2 (MAP) (PeptidaseM) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_08990 - dinB Type: Gene Product:DNA polymerase IV (Pol IV) \| Pathway: \| COG: Replication, recombination and repair CD630_14680 - Type: Gene Product:Putative iron-sulfur protein \| Pathway: \| COG: Energy production and conversion CD630_21241 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_17770 - Type: Gene Product:Putative arsenate reductase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_06550 - Type: Gene Product:Putative beta-lactamase-like protein \| Pathway: \| COG: Function unknown CD630_23040 - Type: Gene Product:Transcriptional regulator, beta-lactams repressorPhage-type \| Pathway: \| COG: Transcription	`NA`	`NA`	0.51	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_16930 - Type: Gene Product:Putative dinitrogenase iron-molybdenum cofactor \| Pathway: \| COG: Function unknown CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms CD630_26650 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_124	25 CD630_10600 - Type: Gene Product:Putative pseudouridylate synthase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_22480 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_19500 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_09390 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_17260 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_10440 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_14580 - wrbA Type: Gene Product:Putative flavodoxin protein \| Pathway: \| COG: Function unknown CD630_23000 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_17980 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription CD630_14550 - sigA1 Type: Gene Product:RNA polymerase sigma factor SigA1 (sigma-43) \| Pathway: \| COG: Transcription CD630_17960 - Type: Gene Product:Putative nitrite and sulfite reductase subunit \| Pathway: \| COG: Energy production and conversion CD630_06370 - Type: Gene Product:Putative acetyltransferase \| Pathway: \| COG: Function unknown CD630_08800 - Type: Gene Product:Putative protease \| Pathway: \| COG: Function unknown CD630_15080 - Type: Gene Product:Putative iron-sulfur binding protein \| Pathway: \| COG: Energy production and conversion CD630_08820 - glgC Type: Gene Product:Glucose-1-phosphate adenylyltransferase \| Pathway: Glycan biosynthesis \| COG: Carbohydrate transport and metabolism CD630_22490 - Type: Gene Product:Putative ATPase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_14570 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_14540 - dnaG Type: Gene Product:DNA primase \| Pathway: \| COG: Replication, recombination and repair CD630_14560 - Type: Gene Product:Putative SAM-dependent methyltransferase \| Pathway: \| COG: Function unknown CD630_09400 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_05103 - Type: Gene Product:Putative conjugative transposon protein Tn5397,CTn3-Orf4 \| Pathway: \| COG: CD630_17970 - Type: Gene Product:Coenzyme A disulfide reductase (CoA-disulfidereductase) (CoADR) \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_08810 - Type: Gene Product:Putative protein modulating protease activity \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_23960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_29260 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown	0.000067	`NA`	0.51	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_20480 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription CD630_20610 - Type: Gene Product:Conserved hypothetical protein, DUF1121 family \| Pathway: \| COG: Function unknown TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_377	23 CD630_20690 - Type: Gene Product:Putative molybdopterin cofactor biosynthesisprotein \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_10500 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_10520 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_14510 - folB Type: Gene Product:Dihydroneopterin aldolase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_14430 - Type: Gene Product:Putative Ca++-chelating serine protease, SCP-likeextracellular domain protein \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_20710 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_02940 - Type: Gene Product:ABC-type transport system,bacitracin/multidrug-family permease \| Pathway: \| COG: Function unknown CD630_14470 - pabC Type: Gene Product:Aminodeoxychorismate lyase(4-amino-4-deoxychorismate lyase) (ADC lyase) (ADCL) \| Pathway: \| COG: Amino acid transport and metabolism CD630_14530 - aroF Type: Gene Product:Phospho-2-dehydro-3-deoxyheptonate aldolase \| Pathway: \| COG: Amino acid transport and metabolism CD630_14450 - pabA Type: Gene Product:Para-aminobenzoate/anthranilate synthaseglutamine amidotransferase component II [Includes:Para-aminobenzoate synthase glutamine amidotransferasecomponent II; Anthranilate synthase component II] \| Pathway: \| COG: Amino acid transport and metabolism CD630_10480 - Type: Gene Product:Putative phosphodiesterase \| Pathway: \| COG: Function unknown CD630_14490 - folE Type: Gene Product:GTP cyclohydrolase 1 (GTP cyclohydrolase I)(GTP-CH-I) \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_10530 - Type: Gene Product:Putative aminoacyl-tRNA synthetase-associateddomain \| Pathway: \| COG: Function unknown CD630_10510 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: CD630_14500 - folP Type: Gene Product:Dihydropteroate synthase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_20700 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_14520 - folK Type: Gene Product:2-amino-4-hydroxy-6-hydroxymethyldihydropteridinepyrophosphokinase \| Pathway: \| COG: Coenzyme transport and metabolism CD630_14440 - Type: Gene Product:Putative exported polysaccharide deacetylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_14460 - pabB Type: Gene Product:Para-aminobenzoate synthase component I \| Pathway: \| COG: Amino acid transport and metabolism, Coenzyme transport and metabolism CD630_02930 - Type: Gene Product:ABC-type transport system,bacitracin/multidrug-family ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_10490 - ppnK Type: Gene Product:Inorganic polyphosphate/ATP-NAD kinase(Poly(P)/ATP NAD kinase) \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_14480 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_34770 - Type: Gene Product:Putative dCMP deaminase \| Pathway: \| COG: Nucleotide transport and metabolism	0.00042	0.04	0.51	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_16930 - Type: Gene Product:Putative dinitrogenase iron-molybdenum cofactor \| Pathway: \| COG: Function unknown CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_312	5 CD630_18781 - Type: Gene Product:Fragment of conserved hypothetical protein(N-terminal region) \| Pathway: \| COG: Replication, recombination and repair CD630_13750 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_21840 - Type: Gene Product:Putative N-acetylmuramoyl-L-alanine amidase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_18441 - Type: Gene Product:Fragment of putative methyltransferase(N-terminal region) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_36130 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.52	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_15840 - Type: Gene Product:Transcriptional regulator, repressor ROK family \| Pathway: \| COG: Carbohydrate transport and metabolism, Transcription CD630_26650 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_31750 - cggR Type: Gene Product:Transcriptional regulator, SorC family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`