Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 201 - 210 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_108	11 CD630_05240 - Type: Gene Product:Putative peptidase, M20 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_17151 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_08660 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_18990 - Type: Gene Product:Putative dCMP deaminase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_15960 - map2 Type: Gene Product:Methionine aminopeptidase Map2 (MAP) (PeptidaseM) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_08990 - dinB Type: Gene Product:DNA polymerase IV (Pol IV) \| Pathway: \| COG: Replication, recombination and repair CD630_14680 - Type: Gene Product:Putative iron-sulfur protein \| Pathway: \| COG: Energy production and conversion CD630_21241 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_17770 - Type: Gene Product:Putative arsenate reductase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_06550 - Type: Gene Product:Putative beta-lactamase-like protein \| Pathway: \| COG: Function unknown CD630_23040 - Type: Gene Product:Transcriptional regulator, beta-lactams repressorPhage-type \| Pathway: \| COG: Transcription	`NA`	`NA`	0.51	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_16930 - Type: Gene Product:Putative dinitrogenase iron-molybdenum cofactor \| Pathway: \| COG: Function unknown CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms CD630_26650 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_124	25 CD630_10600 - Type: Gene Product:Putative pseudouridylate synthase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_22480 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_19500 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_09390 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_17260 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_10440 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_14580 - wrbA Type: Gene Product:Putative flavodoxin protein \| Pathway: \| COG: Function unknown CD630_23000 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_17980 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription CD630_14550 - sigA1 Type: Gene Product:RNA polymerase sigma factor SigA1 (sigma-43) \| Pathway: \| COG: Transcription CD630_17960 - Type: Gene Product:Putative nitrite and sulfite reductase subunit \| Pathway: \| COG: Energy production and conversion CD630_06370 - Type: Gene Product:Putative acetyltransferase \| Pathway: \| COG: Function unknown CD630_08800 - Type: Gene Product:Putative protease \| Pathway: \| COG: Function unknown CD630_15080 - Type: Gene Product:Putative iron-sulfur binding protein \| Pathway: \| COG: Energy production and conversion CD630_08820 - glgC Type: Gene Product:Glucose-1-phosphate adenylyltransferase \| Pathway: Glycan biosynthesis \| COG: Carbohydrate transport and metabolism CD630_22490 - Type: Gene Product:Putative ATPase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_14570 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_14540 - dnaG Type: Gene Product:DNA primase \| Pathway: \| COG: Replication, recombination and repair CD630_14560 - Type: Gene Product:Putative SAM-dependent methyltransferase \| Pathway: \| COG: Function unknown CD630_09400 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_05103 - Type: Gene Product:Putative conjugative transposon protein Tn5397,CTn3-Orf4 \| Pathway: \| COG: CD630_17970 - Type: Gene Product:Coenzyme A disulfide reductase (CoA-disulfidereductase) (CoADR) \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_08810 - Type: Gene Product:Putative protein modulating protease activity \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_23960 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_29260 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown	0.000067	`NA`	0.51	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_20480 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription CD630_20610 - Type: Gene Product:Conserved hypothetical protein, DUF1121 family \| Pathway: \| COG: Function unknown TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_363	22 CD630_24630 - hrcA Type: Gene Product:Transcriptional regulator, Heat-induciblerepressor HrcA \| Pathway: \| COG: Transcription CD630_20120 - hydD Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Function unknown CD630_20730 - xdhA Type: Gene Product:Xanthine dehydrogenase, molybdenum bindingsubunit \| Pathway: \| COG: Energy production and conversion CD630_08220 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_15020 - deoC Type: Gene Product:Deoxyribose-phosphate aldolase(Phosphodeoxyriboaldolase) (Deoxyriboaldolase) (DERA) \| Pathway: Carbohydrate degradation \| COG: Nucleotide transport and metabolism CD630_08240 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: Function unknown CD630_16370 - Type: Gene Product:Putative calcium-transporting ATPase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_16350 - terD Type: Gene Product:Tellurium resistance protein \| Pathway: \| COG: Signal transduction mechanisms CD630_01320 - Type: Gene Product:Putative DNA helicase, RecD/TraA type \| Pathway: \| COG: Replication, recombination and repair CD630_25490 - Type: Gene Product:ABC-type transport system, sugar-family permease \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_16410 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_16430 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_25470 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_20130 - hydR Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_08230 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: Function unknown CD630_20740 - Type: Gene Product:Putative FAD-binding subunit of xanthinedehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_16400 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_01330 - Type: Gene Product:Putative phosphoribosyl transferase \| Pathway: \| COG: Function unknown CD630_16380 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_25480 - Type: Gene Product:ABC-type transport system, sugar-family permease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_16420 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_25500 - Type: Gene Product:ABC-type transport system, sugar-familyextracellular solute-binding protein \| Pathway: \| COG: Carbohydrate transport and metabolism	0.00025	2.4	0.51	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_395	18 CD630_05760 - virS Type: Gene Product:Sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_07760 - Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription CD630_06010 - ogt1 Type: Gene Product:Methylated-DNA-[protein]-cysteineS-methyltransferase 1 \| Pathway: \| COG: Replication, recombination and repair CD630_27650 - LcpA Type: Gene Product:Surface-anchoring factors, LytR-CpsA-Psr-likeprotein \| Pathway: \| COG: Transcription CD630_13420 - Type: Gene Product:Putative ribonuclease \| Pathway: \| COG: Replication, recombination and repair CD630_20760 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_33670 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_06640 - tcdC Type: Gene Product:Negative regulator of toxin gene expression \| Pathway: \| COG: Function unknown CD630_09790 - Type: Gene Product:Transcriptional regulator, beta-lactams repressorPhage-type \| Pathway: \| COG: Transcription CD630_20650 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription CD630_01810 - Type: Gene Product:Putative membrane-associated metalloprotease, M56family \| Pathway: \| COG: Transcription, Signal transduction mechanisms CD630_08290 - Type: Gene Product:Putative metallo-beta-lactamase superfamilyprotein \| Pathway: \| COG: Function unknown CD630_34080 - Type: Gene Product:Putative DNA mismatch repair ATPase MutS \| Pathway: \| COG: Replication, recombination and repair CD630_12490 - Type: Gene Product:Putative radical SAM-superfamily protein \| Pathway: \| COG: Chromatin structure and dynamics, Transcription CD630_26030 - cdtR Type: Gene Product:Clostridium difficile binary toxin regulatorygene, LytTR family \| Pathway: \| COG: Signal transduction mechanisms CD630_01830 - Type: Gene Product:Putative cell wall hydrolase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_00300 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_01780 - Type: Gene Product:Putative ATPase \| Pathway: \| COG: Function unknown	0.00051	`NA`	0.51	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_18100 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription CD630_35440 - Type: Gene Product:Transcriptional regulator, AsnC/Lrp family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_172	8 CD630_16020 - Type: Gene Product:PTS system, lactose/cellobiose-family IIBcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_19901 - Type: Gene Product:Fragment of transcriptional regulator,beta-lactams repressor (Part 2) \| Pathway: \| COG: Transcription CD630_27120 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_14750 - Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_11740 - Type: Gene Product:Conserved hypothetical protein, DUF795 family,UPF0348 family \| Pathway: \| COG: Function unknown CD630_15980 - Type: Gene Product:Putative excinuclease ABC-like \| Pathway: \| COG: Replication, recombination and repair CD630_21510 - Type: Gene Product:Putative membrane protein, DUF819 family \| Pathway: \| COG: Function unknown CD630_01780 - Type: Gene Product:Putative ATPase \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.51	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_04020 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription CD630_20230 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_21940 - Type: Gene Product:Putative ROK protein \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_189	21 CD630_09540 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_03600 - Type: Gene Product:Transcriptional regulator, GntR family,Tn916-like, CTn1-Orf5 \| Pathway: \| COG: Transcription CD630_09550 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_30540 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_03610 - Type: Gene Product:Two-component sensor histidine kinase Tn916-like,CTn1-Orf6 \| Pathway: \| COG: Signal transduction mechanisms CD630_09470 - Type: Gene Product:Putative phage scaffold protein \| Pathway: \| COG: Function unknown CD630_31290 - Type: Gene Product:Glycosyl hydrolase/phosphorylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_03630 - Type: Gene Product:ABC-type transport system, permease Tn916-like,CTn1-Orf8 \| Pathway: \| COG: Defense mechanisms CD630_30530 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_03620 - Type: Gene Product:Two-component response regulator Tn916-like,CTn1-Orf7 \| Pathway: \| COG: Signal transduction mechanisms CD630_09531 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09530 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_03640 - Type: Gene Product:ABC-type transport system, ATP-binding proteinTn916-like, CTn1-Orf9 \| Pathway: \| COG: Defense mechanisms CD630_09520 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_31300 - bglA Type: Gene Product:6-phospho-beta-glucosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_09560 - Type: Gene Product:Putative XkdN-like phage protein \| Pathway: \| COG: Function unknown CD630_09561 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_09500 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09480 - Type: Gene Product:Putative phage major capsid protein \| Pathway: \| COG: Function unknown CD630_20150 - Type: Gene Product:Putative VanZ-like transposon protein \| Pathway: \| COG: Defense mechanisms CD630_09510 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown	0.25	`NA`	0.51	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_30540 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_94	5 CD630_14240 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_18800 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_31580 - Type: Gene Product:Transcriptional regulator, TRAP family \| Pathway: \| COG: Function unknown CD630_06580 - cdu1 Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription CD630_27880 - Type: Gene Product:Putative membrane protein, GtrA family \| Pathway: \| COG: Function unknown	`NA`	`NA`	0.51	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_06290 - Type: Gene Product:Transcriptional regulator, Crp family \| Pathway: \| COG: Transcription CD630_06580 - cdu1 Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_15	20 CD630_09900 - leuC Type: Gene Product:3-isopropylmalate dehydratase large subunit \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_17160 - Type: Gene Product:Putative permease \| Pathway: \| COG: Nucleotide transport and metabolism CD630_25000 - argH Type: Gene Product:Argininosuccinate lyase (Arginosuccinase) (ASAL) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_25210 - leuS Type: Gene Product:Leucyl-tRNA synthetase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_09910 - leuD Type: Gene Product:3-isopropylmalate dehydratase small subunit \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_22450 - asnC Type: Gene Product:Asparaginyl-tRNA synthetase (Asparagine--tRNAligase) (AsnRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_32560 - valS Type: Gene Product:valyl-tRNA synthetase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_17170 - Type: Gene Product:Conserved hypothetical protein, DUF917 family \| Pathway: \| COG: Function unknown CD630_00500 - proS Type: Gene Product:Prolyl-tRNA synthetase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_26950 - asnA Type: Gene Product:Aspartate--ammonia ligase (Asparagine synthetaseA) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_05740 - thrS Type: Gene Product:Threonyl-tRNA synthetase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_26940 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_00140 - serS1 Type: Gene Product:Seryl-tRNA synthetase 1 \| Pathway: Aminoacyl-tRNA biosynthesis \| COG: Translation, ribosomal structure and biogenesis CD630_17180 - Type: Gene Product:Putative hydantoinase (Disrupted IStron) \| Pathway: \| COG: Amino acid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism, Amino acid transport and metabolism, Secondary metabolites biosynthesis, transport and catabolism CD630_00490 - proS Type: Gene Product:Prolyl-tRNA synthetase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_09890 - leuA Type: Gene Product:2-isopropylmalate synthase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_15800 - hom2 Type: Gene Product:Homoserine dehydrogenase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_09920 - leuB Type: Gene Product:3-isopropylmalate dehydrogenase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_15810 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_15210 - tyrS Type: Gene Product:Tyrosyl-tRNA synthetase (Tyrosine--tRNA ligase)(TyrRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis	3.89995e-41	2e-16	0.51	Inferelator: 4 Hypergeometric: 0 TF Influences from Inferelator CD630_06700 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms CD630_20480 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_302	27 CD630_t0820 - tRNA-Leu Type: Gene Product: \| Pathway: \| COG: CD630_05821 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_27341 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_21501 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_20530 - lysA Type: Gene Product:Diaminopimelate decarboxylase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_t0130 - tRNA-Arg Type: Gene Product: \| Pathway: \| COG: CD630_19871 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_12333 - Type: Gene Product:Fragment of putative phage antirepressor protein(part 1) \| Pathway: \| COG: CD630_36290 - Type: Gene Product:PTS system, fructose/mannitol-family IICcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_t0010 - tRNA-Ala Type: Gene Product: \| Pathway: \| COG: CD630_26871 - Type: Gene Product:Putative spore associated protein \| Pathway: \| COG: Function unknown CD630_12334 - Type: Gene Product:Fragment of putative phage antirepressor protein(part 2) \| Pathway: \| COG: CD630_16631 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_26811 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_36270 - dapA4 Type: Gene Product:Dihydrodipicolinate synthase 4 (DHDPS) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_12381 - Type: Gene Product:Fragment of conserved hypothetical protein \| Pathway: \| COG: CD630_04370 - Type: Gene Product:Fragment of integrase Tn1549-like, CTn2(C-terminal region) \| Pathway: \| COG: Replication, recombination and repair CD630_21631 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_t0610 - tRNA-Pro Type: Gene Product: \| Pathway: \| COG: CD630_t0330 - tRNA-Gly Type: Gene Product: \| Pathway: \| COG: CD630_20541 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_20540 - lysC Type: Gene Product:Aspartokinase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_t0320 - tRNA-Leu Type: Gene Product: \| Pathway: \| COG: CD630_t0120 - tRNA-Leu Type: Gene Product: \| Pathway: \| COG: CD630_21021 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_36280 - Type: Gene Product:Putative phosphosugar isomerase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_29740 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	2.8e-29	8.3e-22	0.51	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_36390 - Type: Gene Product:Transcriptional regulator, LysR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_222	18 CD630_22450 - asnC Type: Gene Product:Asparaginyl-tRNA synthetase (Asparagine--tRNAligase) (AsnRS) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_26180 - ileS Type: Gene Product:Isoleucyl-tRNA synthetase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_12840 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_20340 - argC Type: Gene Product:N-acetyl-gamma-glutamyl-phosphate reductase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_07500 - Type: Gene Product:ABC-type transport system, aminoacid-familyextracellular solute-binding protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_17850 - argG Type: Gene Product:Argininosuccinate synthase (Citrulline--aspartateligase) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_21180 - thrC Type: Gene Product:Threonine synthase \| Pathway: \| COG: Amino acid transport and metabolism CD630_07510 - Type: Gene Product:ABC-type transport system, aminoacid-familypermease \| Pathway: \| COG: Amino acid transport and metabolism CD630_20320 - argB Type: Gene Product:Acetylglutamate kinase \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_12860 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_20330 - argJ Type: Gene Product:Arginine biosynthesis bifunctional protein ArgJ[Includes: Glutamate N-acetyltransferase ; Amino-acidacetyltransferase] \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_21190 - thrB Type: Gene Product:Homoserine kinase (HSK) (HK) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_12830 - Type: Gene Product:Conserved hypothetical protein, UPF0297 family \| Pathway: \| COG: Function unknown CD630_12820 - alaS Type: Gene Product:Alanyl-tRNA synthetase \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_20310 - argM Type: Gene Product:Succinylornithine transaminase (ACOAT) \| Pathway: Amino-acid biosynthesis \| COG: Amino acid transport and metabolism CD630_12850 - Type: Gene Product:Putative Holliday junction resolvase \| Pathway: \| COG: Replication, recombination and repair CD630_07520 - Type: Gene Product:ABC-type transport system, aminoacid-familyATP-binding protein \| Pathway: \| COG: Amino acid transport and metabolism CD630_20300 - argF Type: Gene Product:Ornithine carbamoyltransferase (OTCase) \| Pathway: \| COG: Amino acid transport and metabolism	4.6e-16	0.0000006	0.51	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_33530 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`