Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 191 - 200 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_232	25 CD630_36490 - rlmH Type: Gene Product:Ribosomal RNA large subunit methyltransferase H,SPOUT methyltransferase family \| Pathway: \| COG: Function unknown CD630_32000 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: Function unknown CD630_16080 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: CD630_36530 - dnaD Type: Gene Product:DNA replication protein DnaD/DnaB \| Pathway: \| COG: Replication, recombination and repair CD630_36510 - Type: Gene Product:Putative metallo-beta-lactamase-like hydrolase \| Pathway: \| COG: Function unknown CD630_16100 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_16060 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_06150 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_35610 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_32010 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_16090 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_30240 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_27920 - secA2 Type: Gene Product:Protein translocase secA 2 \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_36500 - Type: Gene Product:PTS system, lactose/cellobiose-family IICcomponent \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_31590 - Type: Gene Product:Putative FemA-like peptidoglycan biosynthesisprotein \| Pathway: \| COG: Function unknown CD630_36540 - dnaC Type: Gene Product:DNA replication protein DnaC \| Pathway: \| COG: Replication, recombination and repair CD630_36520 - Type: Gene Product:Putative peptidase, M1 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_t0650 - tRNA-Ala Type: Gene Product: \| Pathway: \| COG: CD630_16070 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_16110 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_17870 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription CD630_18850 - Type: Gene Product:Putative acetylesterase \| Pathway: \| COG: Function unknown CD630_06160 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription CD630_06140 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_30230 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	0.0000000000000025	3.1	0.50	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_02760 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_30940 - Type: Gene Product:Transcriptional regulator, sigma-54-dependent \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_343	23 CD630_33701 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf2 \| Pathway: \| COG: Function unknown CD630_26760 - thlA2 Type: Gene Product:Acetoacetyl-CoA thiolase 2 \| Pathway: \| COG: Lipid transport and metabolism CD630_02210 - purG Type: Gene Product:Phosphoribosylformylglycinamidine cyclo-ligase \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_28190 - Type: Gene Product:Putative amino acid racemase \| Pathway: \| COG: Amino acid transport and metabolism CD630_02230 - purH Type: Gene Product:Bifunctional purine biosynthesis protein purH[Includes: Phosphoribosylaminoimidazolecarboxamideformyltransferase ; IMP cyclohydrolase] \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_26770 - scoA Type: Gene Product:Succinyl CoA:3-oxoacid CoA-transferase subunit A \| Pathway: \| COG: Lipid transport and metabolism CD630_02250 - purL Type: Gene Product:Phosphoribosylformylglycinamidine synthase \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_22320 - asrB Type: Gene Product:Anaerobic sulfite reductase subunit B \| Pathway: \| COG: Energy production and conversion CD630_22300 - Type: Gene Product:Putative formate/nitrite transporter \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_26790 - bdhA Type: Gene Product:3-hydroxybutyrate dehydrogenase \| Pathway: \| COG: Function unknown CD630_06110 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_04760 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_33710 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf3 \| Pathway: \| COG: Function unknown CD630_02200 - purF Type: Gene Product:Amidophosphoribosyltransferase \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_02240 - purD Type: Gene Product:Phosphoribosylamine--glycine ligase \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_02220 - purN Type: Gene Product:Phosphoribosylglycinamide formyltransferase \| Pathway: Purine metabolism \| COG: Nucleotide transport and metabolism CD630_22310 - asrC Type: Gene Product:Anaerobic sulfite reductase subunit C \| Pathway: \| COG: Energy production and conversion CD630_22330 - asrA Type: Gene Product:Anaerobic sulfite reductase subunit A (Anaerobicsulfite reductase iron-sulfur subunit) \| Pathway: \| COG: Energy production and conversion CD630_06100 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_26800 - Type: Gene Product:Putative permease \| Pathway: \| COG: Amino acid transport and metabolism, Carbohydrate transport and metabolism CD630_26780 - scoB Type: Gene Product:Succinyl CoA:3-oxoacid CoA-transferase subunit B \| Pathway: \| COG: Lipid transport and metabolism CD630_04750 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Replication, recombination and repair CD630_33720 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf4 \| Pathway: \| COG:	0.25	1.2	0.50	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_06930 - Type: Gene Product:Transcriptional regulator, MerR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_81	18 CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription CD630_24540 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_25320 - Type: Gene Product:Aminotransferase, alanine--glyoxylatetransaminase \| Pathway: \| COG: Amino acid transport and metabolism CD630_23880 - Type: Gene Product:Putative peptidoglycan-binding/hydrolysingprotein \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_25300 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_24510 - Type: Gene Product:Putative CRISPR-associated ATP-dependenthelicase \| Pathway: \| COG: Replication, recombination and repair CD630_25310 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_25290 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_t0250 - tRNA-Met Type: Gene Product: \| Pathway: \| COG: CD630_24530 - Type: Gene Product:Putative CRISPR-associated negativeautoregulator \| Pathway: \| COG: Replication, recombination and repair CD630_15180 - feoA Type: Gene Product:Ferrous iron transport protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_24520 - Type: Gene Product:Putative CRISPR-associated protein \| Pathway: \| COG: Replication, recombination and repair CD630_06840 - Type: Gene Product:Putative ATP-dependent peptidase, M41 family \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_23890 - Type: Gene Product:Putative beta-lactams signal-transducer \| Pathway: \| COG: Transcription, Signal transduction mechanisms CD630_15120 - panC Type: Gene Product:Pantothenate synthetase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_15170 - feoB Type: Gene Product:Ferrous iron transport protein B \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_15130 - panB Type: Gene Product:Ketopantoate hydroxymethyltransferase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_15140 - panG Type: Gene Product:Putative ketopantoate reductase \| Pathway: \| COG: Coenzyme transport and metabolism	0.0000088	`NA`	0.50	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_33	18 CD630_t0070 - tRNA-Gly Type: Gene Product: \| Pathway: \| COG: CD630_t0350 - tRNA-Gln Type: Gene Product: \| Pathway: \| COG: CD630_t0150 - tRNA-Ser Type: Gene Product: \| Pathway: \| COG: CD630_t0330 - tRNA-Gly Type: Gene Product: \| Pathway: \| COG: CD630_t0780 - tRNA-Arg Type: Gene Product: \| Pathway: \| COG: CD630_t0400 - tRNA-Met Type: Gene Product: \| Pathway: \| COG: CD630_t0320 - tRNA-Leu Type: Gene Product: \| Pathway: \| COG: CD630_t0110 - tRNA-Tyr Type: Gene Product: \| Pathway: \| COG: CD630_t0580 - tRNA-Ser Type: Gene Product: \| Pathway: \| COG: CD630_t0340 - tRNA-Arg Type: Gene Product: \| Pathway: \| COG: CD630_t0390 - tRNA-Met Type: Gene Product: \| Pathway: \| COG: CD630_t0120 - tRNA-Leu Type: Gene Product: \| Pathway: \| COG: CD630_t0200 - tRNA-His Type: Gene Product: \| Pathway: \| COG: CD630_t0410 - tRNA-His Type: Gene Product: \| Pathway: \| COG: CD630_t0300 - tRNA-Thr Type: Gene Product: \| Pathway: \| COG: CD630_t0590 - tRNA-Pro Type: Gene Product: \| Pathway: \| COG: CD630_t0310 - tRNA-Tyr Type: Gene Product: \| Pathway: \| COG:	0	0	0.50	Inferelator: 0 Hypergeometric: 0 TF Influences from Inferelator `No TF influences from Inferelator` TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_98	23 CD630_27260 - glyA Type: Gene Product:Serine hydroxymethyltransferase \| Pathway: One-carbon metabolism \| COG: Amino acid transport and metabolism CD630_10030 - fumA Type: Gene Product:Fumarate hydratase class I, subunit A \| Pathway: \| COG: Energy production and conversion CD630_22080 - Type: Gene Product:Transcriptional regulator, MarR family \| Pathway: \| COG: Transcription CD630_17500 - Type: Gene Product:Putative CoA enzyme activase \| Pathway: \| COG: Lipid transport and metabolism CD630_10050 - Type: Gene Product:Putative NAD-dependent malic enzyme \| Pathway: \| COG: Energy production and conversion CD630_06670 - cdd4 Type: Gene Product:ABC-type transport system,lantibiotic/multidrug-family ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_06650 - cdd2 Type: Gene Product:ABC-type transport system,lantibiotic/multidrug-family permease \| Pathway: \| COG: Function unknown CD630_06690 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_17490 - Type: Gene Product:Putative 2-hydroxyacyl-CoA dehydratase \| Pathway: \| COG: Amino acid transport and metabolism CD630_23080 - Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_09770 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_09750 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_27270 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_09870 - Type: Gene Product:Putative phosphatase/hydrolase \| Pathway: \| COG: Replication, recombination and repair CD630_10040 - fumB Type: Gene Product:Fumarate hydratase class I, subunit B \| Pathway: \| COG: Energy production and conversion CD630_06660 - cdd3 Type: Gene Product:ABC-type transport system,lantibiotic/multidrug-family permease \| Pathway: \| COG: Function unknown CD630_06680 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_27280 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_23070 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_09880 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_09760 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_13920 - Type: Gene Product:Putative endoribonuclease \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_22070 - Type: Gene Product:Putative flavodoxin \| Pathway: \| COG: Function unknown	0.00019	0	0.50	Inferelator: 0 Hypergeometric: 0 TF Influences from Inferelator `No TF influences from Inferelator` TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_268	7 CD630_22951 - Type: Gene Product:Fragment of putative cell surface protein(C-terminal region) \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_31561 - Type: Gene Product:Fragment of conserved hypothetical protein (Part2) \| Pathway: \| COG: Function unknown, Function unknown CD630_06030 - Type: Gene Product:Fragment of putative membrane protein (C-terminalregion) \| Pathway: \| COG: CD630_08460 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_20071 - Type: Gene Product:Fragment of conserved hypothetical protein(N-terminal region) \| Pathway: \| COG: Transcription CD630_27850 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_06020 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG:	`NA`	`NA`	0.50	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_20450 - Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_68	4 CD630_12910 - dacF Type: Gene Product:D-alanyl-D-alanine carboxypeptidase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_12900 - Type: Gene Product:Putative small acid-soluble spore protein SASP \| Pathway: \| COG: CD630_07080 - pepD Type: Gene Product:Peptidase D, aminoacyl-histidine dipeptidase \| Pathway: \| COG: Amino acid transport and metabolism CD630_32220 - sdaB Type: Gene Product:L-serine dehydratase \| Pathway: \| COG: Amino acid transport and metabolism	`NA`	`NA`	0.50	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_06290 - Type: Gene Product:Transcriptional regulator, Crp family \| Pathway: \| COG: Transcription CD630_25990 - Type: Gene Product:Putative transcriptional regulator \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_39	22 CD630_36360 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_36361 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_04790 - spaE Type: Gene Product:ABC-type transport system,lantibiotic/multidrug-family permease \| Pathway: \| COG: Function unknown CD630_22990 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_11261 - Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_27130 - ldtcd2 Type: Gene Product:L,D-transpeptidases \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_04850 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_27150 - gtaB Type: Gene Product:UTP--glucose-1-phosphate uridylyltransferase \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_04620 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_04810 - spaR Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_04640 - Type: Gene Product:Putative beta-lactamase-like hydrolase \| Pathway: \| COG: Function unknown CD630_36350 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_36370 - Type: Gene Product:Putative NADPH-dependent FMN reductase \| Pathway: \| COG: Function unknown CD630_11270 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_04780 - spaF Type: Gene Product:ABC-type transport system,lantibiotic/multidrug-family ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_36380 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_27140 - galE Type: Gene Product:UDP-glucose 4-epimerase \| Pathway: Carbohydrate metabolism \| COG: Cell wall/membrane/envelope biogenesis CD630_04630 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_04800 - spaG Type: Gene Product:ABC-type transport system,lantibiotic/multidrug-family permease \| Pathway: \| COG: Function unknown CD630_04860 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_04820 - spaK Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_04610 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms	0.5	`NA`	0.51	Inferelator: 2 Hypergeometric: 2 TF Influences from Inferelator CD630_01710 - rex Type: Gene Product:Transcriptional regulator, Redox-sensingrepressor Rex \| Pathway: \| COG: Transcription CD630_02760 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_07720 - sigF Type: Gene Product:RNA polymerase sigma-F factor \| Pathway: \| COG: Transcription CD630_26430 - sigE Type: Gene Product:RNA polymerase sigma-E factor \| Pathway: \| COG: Transcription
Module_24	20 CD630_19840 - Type: Gene Product:Putative hydrolase, NUDIX family \| Pathway: \| COG: Replication, recombination and repair CD630_30850 - mngB Type: Gene Product:Alpha-mannosidase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_05820 - Type: Gene Product:Putative pyruvate phosphate dikinase,PEP/pyruvate-binding \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_30320 - Type: Gene Product:Putative pyridoxal phosphate-dependenttransferase \| Pathway: \| COG: Amino acid transport and metabolism CD630_03020 - rbsC Type: Gene Product:ABC-type transport system, ribose-specificpermease \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_02990 - rbsK Type: Gene Product:Ribokinase, pfkB family \| Pathway: Carbohydrate metabolism \| COG: Carbohydrate transport and metabolism CD630_31650 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Replication, recombination and repair CD630_31670 - Type: Gene Product:Putative phosphatidylethanolamine-bindingregulatory protein \| Pathway: \| COG: Function unknown CD630_03030 - argE Type: Gene Product:Acetylornithine deacetylase ArgE \| Pathway: \| COG: Amino acid transport and metabolism CD630_03000 - rbsB Type: Gene Product:ABC-type transport system, ribose-specificextracellular solute-binding protein \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_05890 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_30870 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription CD630_t0450 - tRNA-Val Type: Gene Product: \| Pathway: \| COG: CD630_30860 - mngA Type: Gene Product:PTS system, 2-O-a-mannosyl-D-glycerate-specificIIABC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_03010 - rbsA Type: Gene Product:ABC-type transport system, ribose-specificATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_05810 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_03040 - Type: Gene Product:Conserved hypothetical protein, DUF1355 family \| Pathway: \| COG: Function unknown CD630_05900 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_23861 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_02980 - rbsR Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription	0.000009	`NA`	0.51	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_02980 - rbsR Type: Gene Product:Transcriptional regulator, LacI family \| Pathway: \| COG: Transcription CD630_30870 - Type: Gene Product:Transcriptional regulator, RpiR family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_403	22 CD630_16970 - ribH Type: Gene Product:6,7-dimethyl-8-ribityllumazine synthase \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_24990 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_14780 - feoA Type: Gene Product:Ferrous iron transport protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_14800 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_16490 - Type: Gene Product:ABC-type transport system, iron-familyATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_16990 - ribE Type: Gene Product:Riboflavin synthase alpha subunit \| Pathway: \| COG: Coenzyme transport and metabolism CD630_28941 - Type: Gene Product:Putative holin \| Pathway: \| COG: Function unknown CD630_28940 - Type: Gene Product:Putative cell wall hydrolase/autolysin \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_31340 - Type: Gene Product:PTS system, fructose-like IIABC component \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_19990 - fldX Type: Gene Product:Flavodoxin \| Pathway: \| COG: Energy production and conversion CD630_16470 - Type: Gene Product:ABC-type transport system, iron-family permease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_33871 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf25 \| Pathway: \| COG: Function unknown CD630_33870 - Type: Gene Product:Putative conjugative transposon proteinTn916-like, CTn7-Orf24 \| Pathway: \| COG: Function unknown CD630_17000 - ribD Type: Gene Product:Riboflavin biosynthesis protein ribD [Includes:Diaminohydroxyphosphoribosylaminopyrimidine deaminase ;5-amino-6-(5-phosphoribosylamino)uracil reductase] \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_14790 - feoB1 Type: Gene Product:Ferrous iron transport protein B \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_16480 - Type: Gene Product:ABC-type transport system, iron-family permease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_31350 - Type: Gene Product:Putative fructose-1-6-bisphosphate aldolase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_16980 - ribBA Type: Gene Product:Riboflavin biosynthesis protein ribBA [Includes:3,4-dihydroxy-2-butanone 4-phosphate synthase; GTPcyclohydrolase-2] \| Pathway: Cofactor biosynthesis \| COG: Coenzyme transport and metabolism CD630_28950 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_16500 - Type: Gene Product:ABC-type transport system, iron-familyextracellular substrate-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_28930 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_14770 - feoA Type: Gene Product:Ferrous iron transport protein \| Pathway: \| COG: Inorganic ion transport and metabolism	0.000013	`NA`	0.51	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_22140 - SinR Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`