Organism : Campylobacter jejuni | Module List :
Regulation information for Cj0188c(Mouseover regulator name to see its description)
Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
|Motif Id||e-value||Consensus||Motif Logo|
Functional Enrichment for Cj0188c
Module neighborhood information for Cj0188c
|Gene||Common Name||Description||Module membership|
|Cj0086c||ung||uracil-DNA glycosylase (NCBI ptt file)||18, 47|
|Cj0174c||Cj0174c||putative iron-uptake ABC transport system permease protein (NCBI ptt file)||7, 148|
|Cj0177||Cj0177||putative lipoprotein (NCBI ptt file)||7, 40|
|Cj0182||Cj0182||transmembrane transport protein (NCBI ptt file)||7, 33|
|Cj0185c||Cj0185c||phnA-like protein (NCBI ptt file)||7, 29|
|Cj0188c||Cj0188c||hypothetical protein Cj0188c (NCBI ptt file)||7, 47|
|Cj0246c||Cj0246c||putative MCP-domain signal transduction protein (NCBI ptt file)||47, 88|
|Cj0248||Cj0248||hypothetical protein Cj0248 (NCBI ptt file)||47, 88|
|Cj0255c||Cj0255c||exodeoxyribonuclease (NCBI ptt file)||7, 23|
|Cj0324||ubiE||ubiquinonemenaquinone biosynthesis methlytransferase (VIMSS-AUTO)||7, 70|
|Cj0447||Cj0447||hypothetical protein Cj0447 (NCBI ptt file)||41, 47|
|Cj0505c||Cj0505c||putative aminotransferase (degT family) (NCBI ptt file)||47, 88|
|Cj0517||crcB||CRCB protein homolog (NCBI ptt file)||47, 138|
|Cj0571||Cj0571||putative transcriptional regulator (NCBI ptt file)||7, 167|
|Cj0635||Cj0635||hypothetical protein Cj0635 (NCBI ptt file)||7, 109|
|Cj0650||Cj0650||putative ATP /GTP binding protein (NCBI ptt file)||7, 17|
|Cj0661c||era||GTP-binding protein ERA homolog (NCBI ptt file)||47, 117|
|Cj0777||Cj0777||putative ATP-dependent DNA helicase (NCBI ptt file)||26, 47|
|Cj0890c||Cj0890c||putative sensory transduction transcriptional regulator (NCBI ptt file)||7, 55|
|Cj0912c||cysM||cysteine synthase (NCBI ptt file)||7, 111|
|Cj0939c||Cj0939c||hypothetical protein Cj0939c (NCBI ptt file)||47, 132|
|Cj0951c||Cj0951c||putative MCP-domain signal transduction protein (NCBI ptt file)||47, 122|
|Cj0958c||Cj0958c||putative membrane protein (NCBI ptt file)||26, 47|
|Cj0959c||Cj0959c||hypothetical protein Cj0959c (NCBI ptt file)||46, 47|
|Cj0960c||rnpA||putative ribonuclease P protein component (NCBI ptt file)||47, 135|
|Cj0961c||rpmH||50S ribosomal protein L34 (NCBI ptt file)||47, 103|
|Cj0962||Cj0962||putative acetyltransferase (NCBI ptt file)||47, 60|
|Cj0973||Cj0973||hypothetical protein Cj0973 (NCBI ptt file)||7, 141|
|Cj0981c||Cj0981c||transmembrane transport protein (NCBI ptt file)||26, 47|
|Cj1011||Cj1011||putative membrane protein (NCBI ptt file)||47, 132|
|Cj1012c||Cj1012c||putative membrane protein (NCBI ptt file)||47, 117|
|Cj1018c||livK||branched-chain amino-acid ABC transport system periplasmic binding protein (NCBI ptt file)||34, 47|
|Cj1095||Cj1095||putative integral membrane protein (NCBI ptt file)||7, 101|
|Cj1101||Cj1101||ATP-dependent DNA helicase (NCBI ptt file)||7, 96|
|Cj1154c||Cj1154c||small hydrophobic protein (NCBI ptt file)||47, 127|
|Cj1157||dnaX||putative DNA polymerase III subunit gamma (NCBI ptt file)||7, 19|
|Cj1162c||Cj1162c||hypothetical protein Cj1162c (NCBI ptt file)||7, 101|
|Cj1195c||pyrC2||putative dihydroorotase (NCBI ptt file)||47, 162|
|Cj1247c||Cj1247c||hypothetical protein Cj1247c (NCBI ptt file)||7, 17|
|Cj1322||Cj1322||hypothetical protein Cj1322 (NCBI ptt file)||7, 101|
|Cj1346c||dxr||putative 1-deoxy-D-xylulose 5-phosphate reductoisomerase (NCBI ptt file)||47, 92|
|Cj1349c||Cj1349c||possible fibronectin/fibrinogen-binding protein (NCBI ptt file)||47, 92|
|Cj1354||ceuD||enterochelin uptake ATP-binding protein (NCBI ptt file)||7, 121|
|Cj1392||metC'||putative cystathionine beta-lyase, N-terminus (RefSeq)||16, 47|
|Cj1394||Cj1394||putative fumarate lyase (NCBI ptt file)||7, 108|
|Cj1414c||Cj1414c||possible polysaccharide modification protein (NCBI ptt file)||7, 101|
|Cj1472c||Cj1472c||putative membrane protein (NCBI ptt file)||7, 104|
|Cj1565c||pflA||paralysed flagellum protein (NCBI ptt file)||7, 67|
|Cj1587c||Cj1587c||putative ABC transporter (NCBI ptt file)||7, 101|
|Cj1646||iamB||putative ABC transport system permease protein (NCBI ptt file)||7, 92|
Gene Page Help
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
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Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.
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Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.
Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
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CircVisOur circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
- 2. Source gene
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