Organism : Desulfovibrio vulgaris Hildenborough | Module List :
DVU0081

sensory box histidine kinase/response regulator

CircVis
Functional Annotations (9)
Function System
Signal transduction histidine kinase, nitrogen specific cog/ cog
two-component sensor activity go/ molecular_function
two-component response regulator activity go/ molecular_function
two-component signal transduction system (phosphorelay) go/ biological_process
ATP binding go/ molecular_function
regulation of transcription, DNA-dependent go/ biological_process
membrane go/ cellular_component
peptidyl-histidine phosphorylation go/ biological_process
sensory_box tigr/ tigrfam
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for DVU0081
(Mouseover regulator name to see its description)

DVU0081 is regulated by 22 influences and regulates 0 modules.
Regulators for DVU0081 (22)
Regulator Module Operator
DVU0230
DVU1083
41 combiner
DVU0525 41 tf
DVU0539 41 tf
DVU1754 41 tf
DVU2036
DVU2633
41 combiner
DVU2588 41 tf
DVU3142 41 tf
DVU3186
DVU0569
41 combiner
DVUA0143 41 tf
DVUA0151 41 tf
DVU0230
DVU0621
36 combiner
DVU0653 36 tf
DVU0653
DVU2633
36 combiner
DVU0946
DVU2114
36 combiner
DVU1063 36 tf
DVU1517
DVU0539
36 combiner
DVU2423
DVU2588
36 combiner
DVU2423
DVU3142
36 combiner
DVU2588 36 tf
DVU2832
DVU1745
36 combiner
DVU3142 36 tf
DVUA0024 36 tf

Warning: DVU0081 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.
Click on the RegPredict links to explore the motif in RegPredict.

Motif Table (4)
Motif Id e-value Consensus Motif Logo RegPredict
71 2.80e+01 GgaCaTG.CGc
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RegPredict
72 1.50e+03 CctTccCgGa.gCGt
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RegPredict
81 1.70e+03 tGaCAAaA
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RegPredict
82 1.10e+04 TATAAA
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RegPredict
Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for DVU0081

DVU0081 is enriched for 9 functions in 3 categories.
Enrichment Table (9)
Function System
Signal transduction histidine kinase, nitrogen specific cog/ cog
two-component sensor activity go/ molecular_function
two-component response regulator activity go/ molecular_function
two-component signal transduction system (phosphorelay) go/ biological_process
ATP binding go/ molecular_function
regulation of transcription, DNA-dependent go/ biological_process
membrane go/ cellular_component
peptidyl-histidine phosphorylation go/ biological_process
sensory_box tigr/ tigrfam
Module neighborhood information for DVU0081

DVU0081 has total of 24 gene neighbors in modules 36, 41
Gene neighbors (24)
Gene Common Name Description Module membership
DVU0081 sensory box histidine kinase/response regulator 36, 41
DVU0083 hypothetical protein DVU0083 36, 295
DVU0115 aroE shikimate 5-dehydrogenase 41, 295
DVU0316 flgB flagellar basal body rod protein FlgB 36, 193
DVU0366 5-formyltetrahydrofolate cyclo-ligase family protein 41, 210
DVU0484 ABC transporter ATP-binding protein 36, 324
DVU0486 hypothetical protein DVU0486 19, 36
DVU0494 class V aminotransferase 36, 193
DVU0514 FlgA family protein 36, 193
DVU0636 response regulator/GGDEF domain-containing protein 36, 38
DVU1433 hypothetical protein DVU1433 36, 149
DVU1735 hypothetical protein DVU1735 41, 102
DVU1940 anaerobic glycerol-3-phosphate dehydrogenase subunit A 36, 193
DVU2578 response regulator 41, 210
DVU2614 hypothetical protein DVU2614 41, 90
DVU2622 hypothetical protein DVU2622 1, 36
DVU2663 hypothetical protein DVU2663 36, 295
DVU2701 hypothetical protein DVU2701 41, 168
DVU2860 hypothetical protein DVU2860 41, 58
DVU2865 lipoprotein 36, 41
DVU3034 hypothetical protein DVU3034 36, 284
DVU3106 GGDEF domain-containing protein 36, 222
DVU3139 solute-binding family 1 protein 41, 80
DVU3387 hypothetical protein DVU3387 36, 193
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for DVU0081
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend