Organism : Desulfovibrio vulgaris Hildenborough | Module List :
DVU1063

transcriptional regulator

CircVis
Functional Annotations (0)

Warning: No Functional annotations were found!

GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for DVU1063
(Mouseover regulator name to see its description)

DVU1063 is regulated by 21 influences and regulates 40 modules.
Regulators for DVU1063 (21)
Regulator Module Operator
DVU0277
DVU2633
32 combiner
DVU0679
DVU3142
32 combiner
DVU0804
DVU3142
32 combiner
DVU1754
DVU0679
32 combiner
DVU2567 32 tf
DVU2588 32 tf
DVU2588
DVU1967
32 combiner
DVU2832 32 tf
DVU2836
DVU0653
32 combiner
DVU3255
DVU2251
32 combiner
DVU3255
DVU2644
32 combiner
DVU3255
DVU2835
32 combiner
DVU3334
DVU0230
32 combiner
DVU0804 243 tf
DVU1518
DVU0030
243 combiner
DVU1518
DVU2195
243 combiner
DVU1561 243 tf
DVU1745 243 tf
DVU2567 243 tf
DVU2788
DVU0653
243 combiner
DVU3023
DVU0110
243 combiner

Warning: DVU1063 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.
Click on the RegPredict links to explore the motif in RegPredict.

Motif Table (4)
Motif Id e-value Consensus Motif Logo RegPredict
63 5.70e+00 ATAtGgTgCttgaatcAaaTgcAa
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RegPredict
64 5.90e+01 tTg.cccGacggAgATGAtg
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RegPredict
463 1.70e-01 Gct.CTgtcatcATC..gatcA.T
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RegPredict
464 2.70e+00 TtGAAcG.caAgA.cgtTgCaaA
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RegPredict
Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for DVU1063

Warning: No Functional annotations were found!

Module neighborhood information for DVU1063

DVU1063 has total of 27 gene neighbors in modules 32, 243
Gene neighbors (27)
Gene Common Name Description Module membership
DVU0401 hypothetical protein DVU0401 32, 167
DVU0426 chromate transport family protein 3, 32
DVU0613 hypothetical protein DVU0613 32, 268
DVU0888 response regulator 32, 259
DVU0890 hom homoserine dehydrogenase 32, 291
DVU0892 aroL shikimate kinase II 19, 32
DVU0894 aroC chorismate synthase 32, 124
DVU0901 pyrF orotidine 5`-phosphate decarboxylase 32, 304
DVU0904 recJ single-stranded-DNA-specific exonuclease RecJ 32, 84
DVU0906 lipB lipoate-protein ligase B 28, 32
DVU0970 lipoprotein 32, 123
DVU1059 aminotransferase 102, 243
DVU1063 transcriptional regulator 32, 243
DVU1700 metallo-beta-lactamase family protein 239, 243
DVU1707 hypothetical protein DVU1707 243, 244
DVU1733 hypothetical protein DVU1733 72, 243
DVU1747 hypothetical protein DVU1747 92, 243
DVU1996 quaternary ammonium compound-resistance protein QacC 138, 243
DVU2122 type II/IV secretion system protein 59, 243
DVU2149 hypothetical protein DVU2149 32, 326
DVU2157 tail tape meausure protein 32, 259
DVU2186 hypothetical protein DVU2186 21, 243
DVU2207 hypothetical protein DVU2207 118, 243
DVU2262 hypothetical protein DVU2262 21, 243
DVU2539 hypothetical protein DVU2539 2, 32
DVU2868 hypothetical protein DVU2868 32, 38
DVUA0151 DNA-binding protein 32, 322
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for DVU1063
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend