Organism : Geobacter sulfurreducens | Module List :
GSU1853

membrane protein, putative (VIMSS)

CircVis
Functional Annotations (2)
Function System
polysaccharide biosynthetic process go/ biological_process
membrane go/ cellular_component
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for GSU1853
(Mouseover regulator name to see its description)

GSU1853 is regulated by 17 influences and regulates 0 modules.
Regulators for GSU1853 (17)
Regulator Module Operator
GSU0205 124 tf
GSU0284 124 tf
GSU0598 124 tf
GSU0776 124 tf
GSU0811 124 tf
GSU1992 124 tf
GSU2033 124 tf
GSU2113 124 tf
GSU2262 124 tf
GSU2506 124 tf
GSU2625 124 tf
GSU3060 124 tf
GSU0372 66 tf
GSU0551 66 tf
GSU0770 66 tf
GSU2237 66 tf
GSU3087 66 tf

Warning: GSU1853 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
2292 1.80e+03 CagtgttcTaatGAactAATaGaG
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2293 3.00e+03 cGGgc.AGGgGgtTG
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2408 2.90e-11 CCAtaGTTTaAcTGAatAAAGAGA
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2409 7.90e-16 TTgTGaTATATTGaGTTCGCcAAA
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for GSU1853

GSU1853 is enriched for 2 functions in 2 categories.
Enrichment Table (2)
Function System
polysaccharide biosynthetic process go/ biological_process
membrane go/ cellular_component
Module neighborhood information for GSU1853

GSU1853 has total of 49 gene neighbors in modules 66, 124
Gene neighbors (49)
Gene Common Name Description Module membership
GSU0039 GSU0039 hypothetical protein (VIMSS) 66, 124
GSU0251 GSU0251 hypothetical protein (VIMSS) 124, 274
GSU0300 GSU0300 sigma-54 dependent DNA-binding response regulator, interruption-N (VIMSS) 124, 274
GSU0542 GSU0542 GGDEF domain protein (NCBI) 9, 66
GSU0554 GSU0554 conserved hypothetical protein, interruption-N (NCBI) 33, 124
GSU0598 GSU0598 sigma-54 dependent DNA-binding response regulator (VIMSS) 66, 269
GSU0600 GSU0600 hypothetical protein (VIMSS) 90, 124
GSU0757 GSU0757 lipoprotein, putative (VIMSS) 66, 331
GSU1251 GSU1251 BNR repeat domain protein (VIMSS) 66, 104
GSU1252 GSU1252 conserved domain protein (NCBI) 66, 104
GSU1253 GSU1253 hypothetical protein (VIMSS) 66, 104
GSU1471 GSU1471 HD domain protein (VIMSS) 124, 303
GSU1472 GSU1472 hypothetical protein (VIMSS) 124, 303
GSU1473 GSU1473 membrane protein, putative (VIMSS) 124, 303
GSU1474 GSU1474 DedA family protein (NCBI) 124, 303
GSU1475 GSU1475 RNA methyltransferase, TrmH family, group 1 (VIMSS) 124, 335
GSU1476 GSU1476 hypothetical protein (VIMSS) 105, 124
GSU1508 GSU1508 conserved hypothetical protein (VIMSS) 124, 299
GSU1509 GSU1509 glycosyl transferase, group 2 family protein (VIMSS) 88, 124
GSU1595 dut deoxyuridine 5'-triphosphate nucleotidohydrolase (NCBI) 124, 158
GSU1666 GSU1666 iron-sulfur cluster-binding protein (NCBI) 77, 124
GSU1667 GSU1667 hypothetical protein (VIMSS) 88, 124
GSU1677 GSU1677 AMP-binding enzyme/acyltransferase (NCBI) 57, 66
GSU1780 GSU1780 hypothetical protein (VIMSS) 33, 124
GSU1788 GSU1788 NHL repeat domain protein (VIMSS) 33, 124
GSU1853 GSU1853 membrane protein, putative (VIMSS) 66, 124
GSU1854 GSU1854 UDP-glucose/GDP-mannose dehydrogenase family protein (VIMSS) 66, 124
GSU1855 GSU1855 capsule polysaccharide export protein, putative (VIMSS) 66, 124
GSU1993 GSU1993 hypothetical protein (VIMSS) 124, 268
GSU2131 GSU2131 hypothetical protein (VIMSS) 51, 66
GSU2141 GSU2141 ISGsu1, transposase, interruption (VIMSS) 124, 274
GSU2180 GSU2180 ISGsu1, transposase (VIMSS) 124, 274
GSU2181 GSU2181 hypothetical protein (VIMSS) 124, 274
GSU2182 GSU2182 hypothetical protein (VIMSS) 124, 274
GSU2499 GSU2499 hypothetical protein (VIMSS) 66, 341
GSU2501 GSU2501 cytochrome c family protein (NCBI) 66, 341
GSU2503 GSU2503 cytochrome c family protein (NCBI) 6, 66
GSU2505 GSU2505 NHL repeat domain protein (VIMSS) 66, 341
GSU2546 GSU2546 hypothetical protein (VIMSS) 124, 210
GSU2640 GSU2640 hypothetical protein (VIMSS) 66, 95
GSU2641 GSU2641 hypothetical protein (VIMSS) 66, 95
GSU2735 GSU2735 transcriptional regulator, TetR family (NCBI) 65, 66
GSU2741 GSU2741 transcriptional regulator, TetR family (VIMSS) 6, 66
GSU2763 GSU2763 conserved hypothetical protein (VIMSS) 4, 66
GSU2892 GSU2892 hypothetical protein (VIMSS) 124, 130
GSU2895 GSU2895 hypothetical protein (VIMSS) 6, 66
GSU3187 GSU3187 ferredoxin family protein (VIMSS) 77, 124
GSU3313 GSU3313 thiolase, putative (NCBI) 9, 66
GSU3420 GSU3420 lipid A biosynthesis lauroyl acyltransferase, putative (VIMSS) 9, 66
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for GSU1853
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend