Organism : Geobacter sulfurreducens | Module List :
GSU3419

sensor histidine kinase (VIMSS)

CircVis
Functional Annotations (6)
Function System
Signal transduction histidine kinase cog/ cog
two-component sensor activity go/ molecular_function
two-component signal transduction system (phosphorelay) go/ biological_process
ATP binding go/ molecular_function
membrane go/ cellular_component
peptidyl-histidine phosphorylation go/ biological_process
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for GSU3419
(Mouseover regulator name to see its description)

GSU3419 is regulated by 10 influences and regulates 0 modules.
Regulators for GSU3419 (10)
Regulator Module Operator
GSU1320 14 tf
GSU1626 14 tf
GSU2581 14 tf
GSU2587 14 tf
GSU2716 14 tf
GSU2753 14 tf
GSU3217 14 tf
GSU0811 274 tf
GSU1495 274 tf
GSU3418 274 tf

Warning: GSU3419 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
2188 9.80e+03 TattaTtataaTgtaTACatT
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2189 4.30e+02 GcGgTgcTcctGGTG.TgGcG
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2708 4.10e-16 cAcCaATaTtAaCAAGgaGATCAG
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2709 3.80e-14 TGTGaTATATTgAGTTCgCCAAAA
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for GSU3419

GSU3419 is enriched for 6 functions in 3 categories.
Enrichment Table (6)
Function System
Signal transduction histidine kinase cog/ cog
two-component sensor activity go/ molecular_function
two-component signal transduction system (phosphorelay) go/ biological_process
ATP binding go/ molecular_function
membrane go/ cellular_component
peptidyl-histidine phosphorylation go/ biological_process
Module neighborhood information for GSU3419

GSU3419 has total of 38 gene neighbors in modules 14, 274
Gene neighbors (38)
Gene Common Name Description Module membership
GSU0044 GSU0044 salmonella virulence plasmid 65kDa B protein /YD repeat protein (NCBI) 274, 300
GSU0121 GSU0121 nickel-iron hydrogenase, b-type cytochrome subunit (VIMSS) 14, 266
GSU0251 GSU0251 hypothetical protein (VIMSS) 124, 274
GSU0260 GSU0260 universal stress protein family (VIMSS) 14, 178
GSU0300 GSU0300 sigma-54 dependent DNA-binding response regulator, interruption-N (VIMSS) 124, 274
GSU0381 GSU0381 lipoprotein, putative (VIMSS) 274, 296
GSU0394 GSU0394 AcrB/AcrD/AcrF family protein (VIMSS) 14, 229
GSU0411 fliG flagellar motor switch protein FliG (NCBI) 14, 186
GSU0571 folA dihydrofolate reductase (NCBI) 14, 281
GSU0659 GSU0659 polysaccharide deacetylase domain protein (VIMSS) 14, 97
GSU0885 GSU0885 cobyrinic acid a,c-diamide synthase family protein (NCBI) 224, 274
GSU1031 GSU1031 hypothetical protein (VIMSS) 14, 337
GSU1051 GSU1051 hypothetical protein (VIMSS) 274, 291
GSU1064 GSU1064 hypothetical protein (VIMSS) 14, 220
GSU1154 GSU1154 surface repeat protein, putative (NCBI) 14, 268
GSU1204 GSU1204 sodium/hydrogen exchanger family/TrkA domain protein (VIMSS) 14, 282
GSU1300 GSU1300 methyl-accepting chemotaxis protein (VIMSS) 14, 78
GSU1320 GSU1320 sigma-54 dependent DNA-binding response regulator (VIMSS) 14, 174
GSU1371 GSU1371 oxidoreductase, FAD/FMN-binding (NCBI) 14, 107
GSU1482 GSU1482 outer membrane efflux protein (VIMSS) 14, 295
GSU1539 xth exodeoxyribonuclease III (NCBI) 274, 300
GSU1852 GSU1852 membrane protein, putative (VIMSS) 17, 274
GSU1948 GSU1948 hypothetical protein (VIMSS) 14, 292
GSU2119 GSU2119 integrative genetic element Gsu56, integrase (VIMSS) 70, 274
GSU2120 ihfA-2 integration host factor, alpha subunit (NCBI) 70, 274
GSU2141 GSU2141 ISGsu1, transposase, interruption (VIMSS) 124, 274
GSU2173 GSU2173 lipoprotein, putative (VIMSS) 79, 274
GSU2180 GSU2180 ISGsu1, transposase (VIMSS) 124, 274
GSU2181 GSU2181 hypothetical protein (VIMSS) 124, 274
GSU2182 GSU2182 hypothetical protein (VIMSS) 124, 274
GSU2330 GSU2330 membrane protein, putative (VIMSS) 175, 274
GSU2438 GSU2438 prevent-host-death family protein (NCBI) 269, 274
GSU2581 GSU2581 sigma-54 dependent transcriptional regulator (VIMSS) 14, 186
GSU2907 GSU2907 membrane protein, putative (VIMSS) 14, 109
GSU2959 GSU2959 membrane protein, putative (NCBI) 14, 213
GSU2981 GSU2981 TonB-dependent receptor, putative (VIMSS) 14, 148
GSU3418 GSU3418 sigma-54 dependent DNA-binding response regulator (VIMSS) 21, 274
GSU3419 GSU3419 sensor histidine kinase (VIMSS) 14, 274
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for GSU3419
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend