Organism : Methanococcus maripaludis S2 | Module List :
hypothetical protein MMP0698
Functional Annotations (1)
|Uncharacterized protein conserved in archaea||cog/ cog|
Regulation information for MMP0698(Mouseover regulator name to see its description)
Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
|Motif Id||e-value||Consensus||Motif Logo|
Functional Enrichment for MMP0698
|Uncharacterized protein conserved in archaea||cog/ cog|
Module neighborhood information for MMP0698
|Gene||Common Name||Description||Module membership|
|MMP0007||geranylgeranylglyceryl phosphate synthase-like protein||12, 143|
|MMP0145||hpt||adenine phosphoribosyltransferase||137, 143|
|MMP0153||aksA||trans-homoaconitate synthase||1, 143|
|MMP0178||purQ||phosphoribosylformylglycinamidine synthase I||95, 143|
|MMP0179||purL||phosphoribosylformylglycinamidine synthase||66, 143|
|MMP0187||thiC||thiamine biosynthesis protein ThiC||137, 143|
|MMP0228||trm1||N(2),N(2)-dimethylguanosine tRNA methyltransferase||21, 42|
|MMP0264||MscMJ||mechanosensitive ion channel MscS||129, 143|
|MMP0270||Fe-S cluster domain-containing protein||21, 70|
|MMP0271||putative ATP binding nickel incorporation protein||21, 95|
|MMP0272||ABC transporter ATPase||21, 70|
|MMP0273||comA||phosphosulfolactate synthase||21, 70|
|MMP0418||carbohydrate kinase PfkB||60, 137, 143|
|MMP0540||purC||phosphoribosylaminoimidazole-succinocarboxamide synthase||8, 112, 143|
|MMP0606||ribosomal RNA methyltransferase RrmJ/FtsJ||137, 143|
|MMP0607||nrpR||hypothetical protein MMP0607||115, 137, 143|
|MMP0618||hypothetical protein MMP0618||21, 70|
|MMP0619||hypothetical protein MMP0619||21, 70|
|MMP0620||atwA||methyl coenzyme M reductase, component A2||21, 70|
|MMP0697||leuS||leucyl-tRNA synthetase||8, 143|
|MMP0698||hypothetical protein MMP0698||21, 143|
|MMP0879||serS||seryl-tRNA synthetase||27, 143|
|MMP0880||aksF||isopropylmalate/isohomocitrate dehydrogenase||24, 60, 140, 143|
|MMP0904||selD||selenophosphate synthetase||21, 70|
|MMP0954||hypothetical protein MMP0954||21, 70|
|MMP1021||hypothetical protein MMP1021||8, 21|
|MMP1022||hypothetical protein MMP1022||21, 70|
|MMP1023||TetR family transcriptional regulator||8, 21, 78|
|MMP1026||argS||arginyl-tRNA synthetase||12, 21|
|MMP1063||leuA||2-isopropylmalate synthase||81, 143|
|MMP1081||wbpG||putative LPS biosynthesis protein WbpG||137, 143|
|MMP1082||hisH||imidazole glycerol phosphate synthase subunit HisH||66, 143|
|MMP1083||imidazole glycerol phosphate synthase subunit HisF||137, 143|
|MMP1085||hypothetical protein MMP1085||141, 143, 149|
|MMP1122||translation-associated GTPase||137, 143|
|MMP1146||purF||amidophosphoribosyltransferase||7, 60, 137, 143|
|MMP1186||lon||thiol (cysteine) protease||21, 115|
|MMP1198||nitrate/sulfonate/bicarbonate ABC transporter ATPase||12, 143|
|MMP1200||lysA||diaminopimelate decarboxylase||21, 41|
|MMP1259||FAD-dependent pyridine nucleotide-disulfide oxidoreductase||12, 21|
|MMP1317||hypothetical protein MMP1317||21, 115|
|MMP1318||lysS||lysyl-tRNA synthetase||20, 21|
|MMP1496||pheS||phenylalanyl-tRNA synthetase subunit alpha||137, 143|
|MMP1512||alr||alanine racemase||8, 21|
|MMP1513||ald||alanine dehydrogenase||8, 21|
|MMP1527||aspartate aminotransferase||8, 21|
|MMP1583||S-adenosylmethionine decarboxylase-like protein||21, 112|
|MMP1584||spermidine synthase||11, 21|
|MMP1592||trpS||tryptophanyl-tRNA synthetase||27, 143|
|MMP1594||hypothetical protein MMP1594||51, 143|
|MMP1611||hypothetical protein MMP1611||21, 106|
|MMP1657||hypothetical protein MMP1657||21, 28|
|MMP1681||hypothetical protein MMP1681||21, 143|
|MMP1682||recJ||single stranded DNA-specific exonuclease||21, 106|
|MMP1704||hypothetical protein MMP1704||21, 115|
|MMP1706||H/ACA RNA-protein complex component Nop10p||20, 21|
|MMP1707||aIF2_alpha||translation initiation factor IF-2 subunit alpha||20, 21|
Gene Page Help
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
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Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.
You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".
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Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.
Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
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CircVisOur circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
- 2. Source gene
- 3. Target genes (other module members)
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