Rv1129c Transcriptional regulator, XRE family

Product Feature Type Start End Strand Length AA Length is TF
Rv1129c Transcriptional regulator, XRE family CDS 1253074 1254534 - 1 461 486 FALSE

Rv1129c (Transcriptional regulator, XRE family) is predicted to be co-regulated in modules bicluster_0166 with residual 0.50 and bicluster_0380 with residual 0.52.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 0.00 for bicluster_0166 and 0.07 and 0.10 for bicluster_0380 respectively.

These modules are enriched for following go terms: .

This gene is found to be for growth on cholesterol.

Mutant available?: Yes

BASS Score Re-Annotated Start Tuberculist Annotated Start
-1.047 1254510 1254534
Last update: 11/20/2020 - 12:11
BEI Mutant Available BEI Mutant ID BEI MT Number BEI Target ID Order from BEI
Yes NR-18306 MT1161 1980
Product (LegacyBRC) Product (RefSeq)
Operon # Operon
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Not assigned Not assigned
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15608269 NP_215645.1 Run

response to host immune response

response to host immune response

Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detecting the immune response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.
GO Category: 
Total items in this category:  
No TFOE experiment results were found
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.000000 0.02

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated: 0.0014152
p-value INH: 0.988908
Displaying 1 - 17 of 17
Condition Count Day Doublings Fitness U.I Plots
D17I 3 17 19.15 14.06 I
D21I 4 21 23.23 14.28 I
D24I 3 24 26.60 13.21 I
D28I 4 28 30.61 13.67 I
D3I 3 3 3.83 14.77 I
D5I 9 5 6.00 15.04 I
D7I 18 7 8.14 15.53 I
D14I 4 14 15.63 14.78 I
D14U 4 14 15.63 14.57 U
D17U 3 17 19.15 14.21 U
D21U 4 21 23.23 14.45 U
D24U 3 24 26.60 13.94 U
D28U 4 28 30.61 14.11 U
D0U 27 0 0.00 14.87 U
D3U 3 3 3.83 14.82 U
D5U 17 5 6.00 14.83 U
D7U 19 7 8.14 15.07 U