Rv1663 Polyketide synthase Pks17

Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv1663 pks17 Polyketide synthase Pks17 CDS 1886512 1888020 + 1 509 502 FALSE

Rv1663 (Polyketide synthase Pks17) is predicted to be co-regulated in modules bicluster_0041 with residual 0.83 and bicluster_0109 with residual 0.50.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 48.00 for bicluster_0041 and 1.00 and 8.40 for bicluster_0109 respectively.

These modules are enriched for following go terms: biosynthetic process, cellular amide metabolic process, monocarboxylic acid metabolic process, amide binding, amino acid binding, vitamin binding amide binding, amino acid binding, vitamin binding, carboxylic acid binding.

This gene is found to be for growth on cholesterol.

Mutant available?:

BASS Score Distance to Tuberculist Start Codon Internal TSS Re-Annotated Start Tuberculist Annotated Start
-0.866 1044 1887556 1886488 1886512
Product (LegacyBRC) Product (RefSeq)
Probable polyketide synthase pks17 polyketide synthase pks17
Operon # Operon
1090 - - -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics


Not assigned Not assigned
Locus Tuberculist Genome View


Locus Tag KEGG Pathways


not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network


GI Number Protein ID Blast Conserved Domains
15608801 NP_216179.1 Run

plasma membrane

plasma membrane

The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
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unsaturated fatty acid biosynthetic process

unsaturated fatty acid biosynthetic process

The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms.
GO Category: 
Total items in this category:  



The increase in size or mass of an entire organism, a part of an organism or a cell.
GO Category: 
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No TFOE experiment results were found
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.080000 0.59

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: