Rv2136c Undecaprenyl-diphosphatase (EC 3.6.1.27)

Summary
Symbol Product Feature Type Start End Strand Length AA Length is TF
Rv2136c uppP Undecaprenyl-diphosphatase (EC 3.6.1.27) CDS 2396008 2396838 - 831 276 FALSE

Rv2136c (Undecaprenyl-diphosphatase (EC 3.6.1.27)) is predicted to be co-regulated in modules bicluster_0040 with residual 0.36 and bicluster_0285 with residual 0.48.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 1,400.00 and 3,700.00 for bicluster_0040 and 3,800.00 and 4,600.00 for bicluster_0285 respectively.

These modules are enriched for following go terms: .

This gene is found to be for growth on cholesterol.

Mutant available?:

BASS Score Distance to Tuberculist Start Codon Internal TSS New Internal UTR New Primary UTR Primary TSS Re-Annotated Start Tuberculist Annotated Start
-0.638 198 2396640 -216 354 2397210 2396856 2396838
Product (LegacyBRC) Product (RefSeq)
Undecaprenyl-diphosphatase undecaprenyl pyrophosphate phosphatase
Operon # Operon
1399 -
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Undecaprenyl-diphosphatase Peptidoglycan biosynthesis
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

Peptidoglycan biosynthesis

16
Total items in this category:  
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15609273 NP_216652.1 Run
GO:0050380

undecaprenyl-diphosphatase activity

undecaprenyl-diphosphatase activity

Details: 
Catalysis of the reaction: all-trans-undecaprenyl diphosphate + H(2)O = all-trans-undecaprenyl phosphate + H(+) + phosphate.
GO Category: 
molecular_function
1
Total items in this category:  
GO:0051409

response to nitrosative stress

response to nitrosative stress

Details: 
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrosative stress stimulus. Nitrosative stress is a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions.
GO Category: 
biological_process
14
Total items in this category:  
No TFOE experiment results were found
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.470000 1.27

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: