Rv3249c Transcriptional regulator, TetR family

Rv3249c (Transcriptional regulator, TetR family) is predicted to be co-regulated in modules bicluster_0063 with residual 0.56 and bicluster_0167 with residual 0.51.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.01 and 37.00 for bicluster_0063 and 0.00 and 49.00 for bicluster_0167 respectively.

These modules are enriched for following go terms: .

This gene is found to be for growth on cholesterol.

Mutant available?:

Displaying 11 - 20 of 129
Gene Target Differential Expression Distance Expression pvalue Type
No -12 -0.16 0.795437 Primary.TSS
Programmed cell death toxin YdcE
No -73 -0.1 0.731598 CDS
Cytochrome P450 135A1
No 15 0.08 0.859588 CDS
HTH-type transcriptional regulator BetI
No -51 -0.11 0.831567 Primary.TSS
No -87 0.15 0.826556 CDS
Long-chain-fatty-acid--CoA ligase (EC 6.2.1.3)
Induced -7 2.14 4.9e-18 Primary.TSS
No -22 -0.08 0.829237 Primary.TSS
No 59 0.32 0.232794 CDS
Isocitrate lyase (EC 4.1.3.1) / Methylisocitrate lyase (EC 4.1.3.30)
No 3 -0.16 0.817337 Primary.TSS
Possible membrane protein
No -25 -0.06 0.909296 CDS
not assigned to any KEGG Pathway.
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
BioProject Accession GEO Series References Repository Sample Method Sample Type
PRJNA254351 GSM1426960 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1426961 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1426962 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1426963 GSE59086 25232098 GEO Tiling Array RNA
PRJNA254351 GSM1426964 GSE59086 25232098 GEO Tiling Array RNA

TRIP log2 fold abundance change

NA
Displaying 1 - 17 of 17
Condition Count Day Doublings Fitness U.I Plots
D0U 27 0 0.00 13.44 U
D3I 3 3 3.83 13.39 I
D3U 3 3 3.83 13.06 U
D5I 9 5 6.00 13.87 I
D5U 17 5 6.00 13.73 U
D7I 18 7 8.14 13.67 I
D7U 19 7 8.14 13.15 U
D14I 4 14 15.63 11.79 I
D14U 4 14 15.63 11.70 U
D17I 3 17 19.15 10.81 I
D17U 3 17 19.15 10.88 U
D21I 4 21 23.23 10.36 I
D21U 4 21 23.23 11.06 U
D24I 3 24 26.60 9.00 I
D24U 3 24 26.60 9.91 U
D28I 4 28 30.61 8.76 I
D28U 4 28 30.61 10.03 U