P9WIS5 kgd, Rv1248c
Source: Uniprot proteome:up000001584
| Title | id | ORF names | Protein names | PubMed ID | Short | Synonyms | EnsemblBacteria |
|---|---|---|---|---|---|---|---|
| P9WIS5 KGD_MYCTU | Multifunctional 2-oxoglutarate metabolism enzyme (2-hydroxy-3-oxoadipate synthase) (HOA synthase) (HOAS) (EC 2.2.1.5) (2-oxoglutarate carboxy-lyase) (2-oxoglutarate decarboxylase) (Alpha-ketoglutarate decarboxylase) (KG decarboxylase) (KGD) (EC 4.1.1.71) (Alpha-ketoglutarate-glyoxylate carboligase) [Includes: 2-oxoglutarate dehydrogenase E1 component (ODH E1 component) (EC 1.2.4.2) (Alpha-ketoglutarate dehydrogenase E1 component) (KDH E1 component); Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex E2 component) (ODH E2 component) (OGDC-E2) (Dihydrolipoamide succinyltransferase)] | 9634230, 16045627, 16027371, 19019160, 19936047, 19318624, 20416504, 21867916 | kgd | kgd, Rv1248c |
| Binding Site |
|---|
| 581 581 2-oxoglutarate (By similarity)., 606 606 2-oxoglutarate (By similarity)., 956 956 Thiamine pyrophosphate (By similarity)., 1024 1024 2-oxoglutarate (By similarity)., 1042 1042 Allosteric activator (By similarity)., 1058 1058 Allosteric activator (By similarity)., 1146 1146 Allosteric activator (By similarity). |
| Domain | InterPro | Pfam | ProDom | Region | Similarity | SUPFAM |
|---|---|---|---|---|---|---|
| Is a fusion protein with two major domains exhibiting structural features of an E1 and E2 protein, and a short sequence stretch of E1 localized at the N-terminus, which is connected by a linker region to the rest of the protein (By similarity). | PF00198, PF00676, PF02779 | Belongs to the 2-oxoacid dehydrogenase family. Kgd subfamily. |
| SSGCID ID |
|---|
| PDB | Protein Model Portal |
|---|---|
| EC number | KEGG KO | UniPathway |
|---|---|---|
| 2.2.1.5, 4.1.1.71, 1.2.4.2, 2.3.1.61 | Carbohydrate metabolism, tricarboxylic acid cycle, succinate from 2-oxoglutarate (transferase route): step 1/2., Carbohydrate metabolism, tricarboxylic acid cycle, succinyl-CoA from 2-oxoglutarate (dehydrogenase route): step 1/1. |
| HOGENOM | KEGG KO | OMA | OrthoDB |
|---|---|---|---|