Organism : Synechococcus elongatus PCC 7942 | Module List :
Synpcc7942_1357

multi-sensor signal transduction histidine kinase (EC 2.7.13.3) (IMGterm)

CircVis
Functional Annotations (8)
Function System
Signal transduction histidine kinase cog/ cog
two-component sensor activity go/ molecular_function
two-component signal transduction system (phosphorelay) go/ biological_process
ATP binding go/ molecular_function
regulation of transcription, DNA-dependent go/ biological_process
membrane go/ cellular_component
peptidyl-histidine phosphorylation go/ biological_process
sensory_box tigr/ tigrfam
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for Synpcc7942_1357
(Mouseover regulator name to see its description)

Warning: No Regulators were found for Synpcc7942_1357!

Warning: Synpcc7942_1357 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 6 motifs predicted.

Motif Table (6)
Motif Id e-value Consensus Motif Logo
1643 3.80e+00 tgCaAcgCTgaTTgc
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1644 9.80e+01 gac.g.aaCcaACtgCtGa.C
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1645 1.50e+05 CaGAcGGaAAT
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1784 4.50e-03 gCTAGggTgagggc
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1785 1.20e+04 tgtAagGAAActgat
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1786 2.90e+05 GttTttCaGaAatAGAaTt
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for Synpcc7942_1357

Synpcc7942_1357 is enriched for 8 functions in 3 categories.
Enrichment Table (8)
Function System
Signal transduction histidine kinase cog/ cog
two-component sensor activity go/ molecular_function
two-component signal transduction system (phosphorelay) go/ biological_process
ATP binding go/ molecular_function
regulation of transcription, DNA-dependent go/ biological_process
membrane go/ cellular_component
peptidyl-histidine phosphorylation go/ biological_process
sensory_box tigr/ tigrfam
Module neighborhood information for Synpcc7942_1357

Synpcc7942_1357 has total of 52 gene neighbors in modules 41, 88
Gene neighbors (52)
Gene Common Name Description Module membership
Synpcc7942_0053 hypothetical protein 41, 44
Synpcc7942_0083 hypothetical protein 41, 139
Synpcc7942_0084 hypothetical protein 83, 88
Synpcc7942_0131 cyclic nucleotide-binding domain (cNMP-BD) protein 41, 187
Synpcc7942_0153 hypothetical protein 88, 122
Synpcc7942_0192 conserved hypothetical protein YCF60 82, 88
Synpcc7942_0210 hypothetical protein 41, 88
Synpcc7942_0249 L-aspartate ABC transporter ATP-binding protein / neutral amino acid ABC transporter ATP-binding protein / L-glutamate ABC transporter ATP-binding protein (IMGterm) 7, 41
Synpcc7942_0258 hypothetical protein 12, 41
Synpcc7942_0259 hypothetical protein 31, 88
Synpcc7942_0261 [SSU ribosomal protein S18P]-alanine acetyltransferase (EC 2.3.1.128) (IMGterm) 88, 203
Synpcc7942_0268 hypothetical protein 41, 100
Synpcc7942_0453 GAF sensor signal transduction histidine kinase (EC 2.7.13.3) (IMGterm) 8, 88
Synpcc7942_0477 conserved hypothetical protein YCF19 88, 122
Synpcc7942_0495 hypothetical protein 21, 88
Synpcc7942_0542 lipoic acid synthetase (EC:2.8.1.8) 4, 41
Synpcc7942_0550 hypothetical protein 30, 88
Synpcc7942_0667 hypothetical protein 88, 122
Synpcc7942_0679 RNA-binding region RNP-1 88, 112
Synpcc7942_0787 putative purple acid phosphatase (EC:3.1.3.2) 88, 122
Synpcc7942_0844 Phosphoesterase PHP-like 13, 41
Synpcc7942_0911 hypothetical protein 14, 41
Synpcc7942_0917 hypothetical protein 41, 88
Synpcc7942_0975 mraW methyltransferase (EC:2.1.1.-) 17, 41
Synpcc7942_0995 conserved hypothetical protein YCF20 3, 88
Synpcc7942_1036 hypothetical protein 41, 80
Synpcc7942_1072 "cob(I)yrinic acid a,c-diamide adenosyltransferase (EC 2.5.1.17) (IMGterm)" 13, 88
Synpcc7942_1129 hypothetical protein 41, 72
Synpcc7942_1170 ispF MECDP-synthase (EC:4.6.1.12) 41, 104
Synpcc7942_1242 "transcriptional regulator, LysR family (IMGterm)" 41, 179
Synpcc7942_1265 hypothetical protein 41, 61
Synpcc7942_1268 "Phosphoglucomutase (EC:5.4.2.2, EC:5.4.2.8)" 41, 63
Synpcc7942_1272 hypothetical protein 41, 83
Synpcc7942_1357 multi-sensor signal transduction histidine kinase (EC 2.7.13.3) (IMGterm) 41, 88
Synpcc7942_1408 membrane-associated protein 88, 102
Synpcc7942_1563 signal transduction inhibitor 88, 102
Synpcc7942_1565 hypothetical protein 40, 88
Synpcc7942_1765 hypothetical protein 41, 183
Synpcc7942_1858 Heme oxygenase (decyclizing) (EC:1.14.99.3) 31, 88
Synpcc7942_1931 "probable serine/threonine protein phosphatase (EC:3.1.3.16, EC:3.1.3.16)" 41, 90
Synpcc7942_1945 uvrC Excinuclease ABC subunit C (IMGterm) 65, 88
Synpcc7942_1968 hypothetical protein 65, 88
Synpcc7942_2259 rimM 16S rRNA processing protein RimM (IMGterm) 41, 160
Synpcc7942_2327 hypothetical protein 41, 183
Synpcc7942_2438 "putative CheA signal transduction histidine kinase, no good domain identification" 12, 41
Synpcc7942_2502 hypothetical protein 88, 102
Synpcc7942_2548 leuD "3-isopropylmalate dehydratase, small subunit (EC 4.2.1.33) (IMGterm)" 8, 88
Synpcc7942_2571 "Penicillin-binding protein 1A (EC:3.4.-, EC:2.4.1.-)" 88, 123
Synpcc7942_2576 hypothetical protein 88, 131
Synpcc7942_2580 Heat shock protein Hsp70 88, 122
Synpcc7942_2584 probable short chain dehydrogenase 41, 72
Synpcc7942_2599 hypothetical protein 61, 88
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for Synpcc7942_1357
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend