Organism : Bacillus cereus ATCC14579 | Module List :
BC2393

PTS system, diacetylchitobiose-specific IIB component (NCBI ptt file)

CircVis
Functional Annotations (6)
Function System
Phosphotransferase system cellobiose-specific component IIB cog/ cog
sugar:hydrogen symporter activity go/ molecular_function
protein-N(PI)-phosphohistidine-sugar phosphotransferase activity go/ molecular_function
protein-N(PI)-phosphohistidine-sugar phosphotransferase complex go/ cellular_component
phosphoenolpyruvate-dependent sugar phosphotransferase system go/ biological_process
Phosphotransferase system (PTS) kegg/ kegg pathway
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BC2393
(Mouseover regulator name to see its description)

BC2393 is regulated by 30 influences and regulates 0 modules.
Regulators for BC2393 (30)
Regulator Module Operator
BC0630 437 tf
BC0648 437 tf
BC0657 437 tf
BC0848 437 tf
BC0854 437 tf
BC1053 437 tf
BC1724 437 tf
BC1731 437 tf
BC2367 437 tf
BC2386 437 tf
BC2469 437 tf
BC2549 437 tf
BC2558 437 tf
BC2632 437 tf
BC2766 437 tf
BC2794 437 tf
BC2971 437 tf
BC3255 437 tf
BC3522 437 tf
BC3592 437 tf
BC3690 437 tf
BC3922 437 tf
BC4101 437 tf
BC0648 108 tf
BC1059 108 tf
BC1710 108 tf
BC1818 108 tf
BC2358 108 tf
BC3522 108 tf
BC4703 108 tf

Warning: BC2393 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
4132 5.20e+01 Aa.tGgAgtgg
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4133 2.70e+03 CGCCCaCC
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4784 5.30e-01 ggAgGtGt
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4785 3.00e+03 gTaGcTGTgC
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BC2393

BC2393 is enriched for 6 functions in 3 categories.
Module neighborhood information for BC2393

BC2393 has total of 39 gene neighbors in modules 108, 437
Gene neighbors (39)
Gene Common Name Description Module membership
BC0389 BC0389 Spore coat protein B (NCBI ptt file) 223, 437
BC0488 BC0488 UDP-glucose 4-epimerase (NCBI ptt file) 418, 437
BC0610 BC0610 Magnesium and cobalt efflux protein corC (NCBI ptt file) 223, 437
BC0946 BC0946 hypothetical Cytosolic Protein (NCBI ptt file) 437, 444
BC0949 BC0949 hypothetical Membrane Spanning Protein (NCBI ptt file) 108, 307
BC0967 BC0967 hypothetical protein (NCBI ptt file) 108, 245
BC1091 BC1091 Sulfate-binding protein (NCBI ptt file) 418, 437
BC1094 BC1094 Sulfate transport ATP-binding protein cysA (NCBI ptt file) 418, 437
BC1219 BC1219 Integral membrane protein (NCBI ptt file) 38, 437
BC1509 BC1509 Stage IV sporulation protein A (NCBI ptt file) 212, 437
BC1896 BC1896 Phage protein (NCBI ptt file) 144, 437
BC1898 BC1898 Phage protein (NCBI ptt file) 144, 437
BC1999 BC1999 IolS protein (NCBI ptt file) 108, 453
BC2000 BC2000 None 108, 230
BC2084 BC2084 hypothetical Cytosolic Protein (NCBI ptt file) 108, 502
BC2161 BC2161 hypothetical protein (NCBI ptt file) 307, 437
BC2237 BC2237 hypothetical protein (NCBI ptt file) 84, 108
BC2393 BC2393 PTS system, diacetylchitobiose-specific IIB component (NCBI ptt file) 108, 437
BC2394 BC2394 PTS system, diacetylchitobiose-specific IIC component (NCBI ptt file) 108, 250
BC2397 BC2397 ATPase family protein (NCBI ptt file) 437, 524
BC2924 BC2924 Acetyltransferase (NCBI ptt file) 168, 437
BC2926 BC2926 hypothetical protein (NCBI ptt file) 418, 437
BC3078 BC3078 Acetyltransferase (NCBI ptt file) 418, 437
BC3079 BC3079 Acetyltransferase (NCBI ptt file) 418, 437
BC3171 BC3171 Methyltransferase (NCBI ptt file) 108, 253
BC3212 BC3212 Multidrug resistance protein B (NCBI ptt file) 108, 293
BC3315 BC3315 6-aminohexanoate-dimer hydrolase (NCBI ptt file) 108, 277
BC3440 BC3440 Beta-lactamase, type II (NCBI ptt file) 307, 437
BC3523 BC3523 Hemolysin II (NCBI ptt file) 108, 245
BC3683 BC3683 Phosphonates transport system permease protein phnE (NCBI ptt file) 108, 134
BC3685 BC3685 Phosphonates transport ATP-binding protein phnC (NCBI ptt file) 108, 134
BC4325 BC4325 ComE operon protein 4 (NCBI ptt file) 26, 437
BC4428 BC4428 ABC transporter permease protein (NCBI ptt file) 108, 141
BC4429 BC4429 ABC transporter permease protein (NCBI ptt file) 108, 276
BC4463 BC4463 Stage II sporulation protein B (NCBI ptt file) 307, 437
BC4498 BC4498 ThiJ/PfpI family protein (NCBI ptt file) 108, 179
BC4869 BC4869 Minor extracellular protease VPR precursor (NCBI ptt file) 108, 162
BC4956 BC4956 Ribosomal-protein-alanine acetyltransferase (NCBI ptt file) 210, 437
BC5327 BC5327 Stage II sporulation protein R (NCBI ptt file) 108, 321
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BC2393
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend