Organism : Bacillus cereus ATCC14579 | Module List :
BC3315

6-aminohexanoate-dimer hydrolase (NCBI ptt file)

CircVis
Functional Annotations (4)
Function System
beta-lactamase activity go/ molecular_function
6-aminohexanoate-dimer hydrolase activity go/ molecular_function
beta-lactam antibiotic catabolic process go/ biological_process
response to antibiotic go/ biological_process
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BC3315
(Mouseover regulator name to see its description)

BC3315 is regulated by 20 influences and regulates 0 modules.
Regulators for BC3315 (20)
Regulator Module Operator
BC0648 108 tf
BC1059 108 tf
BC1710 108 tf
BC1818 108 tf
BC2358 108 tf
BC3522 108 tf
BC4703 108 tf
BC0954 277 tf
BC1680 277 tf
BC1710 277 tf
BC1915 277 tf
BC2108 277 tf
BC3244 277 tf
BC3255 277 tf
BC4076 277 tf
BC4165 277 tf
BC4256 277 tf
BC4826 277 tf
BC4930 277 tf
BC5010 277 tf

Warning: BC3315 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
4132 5.20e+01 Aa.tGgAgtgg
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4133 2.70e+03 CGCCCaCC
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4470 8.70e-01 a.AagGAgcgc
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4471 4.00e+03 GAAaGg
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BC3315

BC3315 is enriched for 4 functions in 2 categories.
Enrichment Table (4)
Function System
beta-lactamase activity go/ molecular_function
6-aminohexanoate-dimer hydrolase activity go/ molecular_function
beta-lactam antibiotic catabolic process go/ biological_process
response to antibiotic go/ biological_process
Module neighborhood information for BC3315

BC3315 has total of 40 gene neighbors in modules 108, 277
Gene neighbors (40)
Gene Common Name Description Module membership
BC0028 BC0028 SigmaK-factor processing regulatory protein BofA (NCBI ptt file) 245, 277
BC0496 BC0496 Dihydroorotase (NCBI ptt file) 277, 281
BC0500 BC0500 hypothetical protein (NCBI ptt file) 277, 509
BC0501 BC0501 IG hypothetical 18102 (NCBI ptt file) 165, 277
BC0683 BC0683 hypothetical protein (NCBI ptt file) 277, 435
BC0949 BC0949 hypothetical Membrane Spanning Protein (NCBI ptt file) 108, 307
BC0967 BC0967 hypothetical protein (NCBI ptt file) 108, 245
BC1999 BC1999 IolS protein (NCBI ptt file) 108, 453
BC2000 BC2000 None 108, 230
BC2084 BC2084 hypothetical Cytosolic Protein (NCBI ptt file) 108, 502
BC2237 BC2237 hypothetical protein (NCBI ptt file) 84, 108
BC2373 BC2373 DNA integration/recombination/invertion protein (NCBI ptt file) 140, 277
BC2393 BC2393 PTS system, diacetylchitobiose-specific IIB component (NCBI ptt file) 108, 437
BC2394 BC2394 PTS system, diacetylchitobiose-specific IIC component (NCBI ptt file) 108, 250
BC3074 BC3074 None 31, 277
BC3085 BC3085 None 60, 277
BC3171 BC3171 Methyltransferase (NCBI ptt file) 108, 253
BC3212 BC3212 Multidrug resistance protein B (NCBI ptt file) 108, 293
BC3315 BC3315 6-aminohexanoate-dimer hydrolase (NCBI ptt file) 108, 277
BC3523 BC3523 Hemolysin II (NCBI ptt file) 108, 245
BC3683 BC3683 Phosphonates transport system permease protein phnE (NCBI ptt file) 108, 134
BC3685 BC3685 Phosphonates transport ATP-binding protein phnC (NCBI ptt file) 108, 134
BC4122 BC4122 None 139, 277
BC4157 BC4157 Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex (NCBI ptt file) 205, 277
BC4158 BC4158 2-oxoisovalerate dehydrogenase beta subunit (NCBI ptt file) 205, 277
BC4159 BC4159 2-oxoisovalerate dehydrogenase alpha subunit (NCBI ptt file) 205, 277
BC4160 BC4160 Dihydrolipoamide dehydrogenase (NCBI ptt file) 205, 277
BC4161 BC4161 Branched-chain-fatty-acid kinase (NCBI ptt file) 205, 277
BC4162 BC4162 Leucine dehydrogenase (NCBI ptt file) 205, 277
BC4163 BC4163 Phosphate butyryltransferase (NCBI ptt file) 205, 277
BC4165 BC4165 Sigma-54-dependent transcriptional activator (NCBI ptt file) 277, 518
BC4428 BC4428 ABC transporter permease protein (NCBI ptt file) 108, 141
BC4429 BC4429 ABC transporter permease protein (NCBI ptt file) 108, 276
BC4478 BC4478 ATP-dependent protease La (NCBI ptt file) 277, 361
BC4498 BC4498 ThiJ/PfpI family protein (NCBI ptt file) 108, 179
BC4751 BC4751 Sulfite reductase [NADPH] flavoprotein alpha-component (NCBI ptt file) 245, 277
BC4808 BC4808 Thiamine transporter (NCBI ptt file) 277, 414
BC4869 BC4869 Minor extracellular protease VPR precursor (NCBI ptt file) 108, 162
BC5327 BC5327 Stage II sporulation protein R (NCBI ptt file) 108, 321
BC5435 BC5435 Acriflavin resistance plasma membrane protein (NCBI ptt file) 277, 425
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BC3315
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend