Organism : Bacteroides thetaiotaomicron VPI-5482 | Module List :
NP_809988.1 BT_1075

None

CircVis
Functional Annotations (0)

Warning: No Functional annotations were found!

GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for NP_809988.1
(Mouseover regulator name to see its description)

Warning: No Regulators were found for NP_809988.1!

Warning: NP_809988.1 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
6122 4.90e+01 TcTGttT.t.attcT.CTg.
Loader icon
6123 5.80e+03 gg.ATttGcaGtTT
Loader icon
6604 3.70e+01 T.agaAtTTTGCC
Loader icon
6605 1.80e+04 GGAGTGG
Loader icon
Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for NP_809988.1

Warning: No Functional annotations were found!

Module neighborhood information for NP_809988.1

NP_809988.1 has total of 44 gene neighbors in modules 199, 446
Gene neighbors (44)
Gene Common Name Description Module membership
NP_809920.1 BT_1007 None 400, 446
NP_809985.1 BT_1072 None 199, 446
NP_809986.1 BT_1073 None 199, 446
NP_809987.1 BT_1074 None 199, 446
NP_809988.1 BT_1075 None 199, 446
NP_810125.1 BT_1212 None 199, 400
NP_810126.1 BT_1213 None 199, 400
NP_810127.1 BT_1214 None 199, 400
NP_810128.1 BT_1215 None 199, 400
NP_810129.1 BT_1216 None 199, 400
NP_810130.1 BT_1217 None 199, 400
NP_810950.1 BT_2037 None 107, 199
NP_810951.1 BT_2038 None 199, 460
NP_810952.1 BT_2039 None 199, 460
NP_810953.1 BT_2040 None 199, 460
NP_811030.1 BT_2117 None 199, 262
NP_811031.1 BT_2118 None 199, 262
NP_811032.1 BT_2119 None 199, 262
NP_811281.1 BT_2368 None 355, 446
NP_811404.1 BT_2491 None 351, 446
NP_811405.1 BT_2492 None 351, 446
NP_811415.1 BT_2502 None 199, 400
NP_811416.1 BT_2503 None 199, 460
NP_811417.1 BT_2504 None 199, 460
NP_811804.1 BT_2892 None 23, 446
NP_811805.1 BT_2893 None 23, 446
NP_811806.1 BT_2894 None 23, 446
NP_811807.1 BT_2895 None 23, 446
NP_811808.1 BT_2896 None 23, 446
NP_811809.1 BT_2897 None 23, 446
NP_811810.1 BT_2898 None 281, 446
NP_811811.1 BT_2899 None 281, 446
NP_811972.1 BT_3060 None 199, 262
NP_811973.1 BT_3061 None 199, 262
NP_812083.1 BT_3171 None 23, 446
NP_812398.1 BT_3486 None 259, 446
NP_812399.1 BT_3487 None 259, 446
NP_812400.1 BT_3488 None 259, 446
NP_812401.1 BT_3489 None 259, 446
NP_812444.1 BT_3532 None 23, 446
NP_813295.1 BT_4384 None 199, 359
NP_813554.1 BT_4643 None 199, 443
NP_813555.1 BT_4644 None 199, 443
NP_813561.1 BT_4650 None 199, 320
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for NP_809988.1
Please add your comments for this gene by using the form below. Your comments will be publicly available.

comments powered by Disqus

Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend