Organism : Clostridium acetobutylicum | Module List :
CAC1531

Uncharacterized conserved protein (NCBI ptt file)

CircVis
Functional Annotations (3)
Function System
Uncharacterized conserved protein cog/ cog
signal transducer activity go/ molecular_function
signal transduction go/ biological_process
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for CAC1531
(Mouseover regulator name to see its description)

CAC1531 is regulated by 18 influences and regulates 0 modules.
Regulators for CAC1531 (18)
Regulator Module Operator
CAC0402 139 tf
CAC0474 139 tf
CAC0865 139 tf
CAC1469 139 tf
CAC1915 139 tf
CAC1941 139 tf
CAC2546 139 tf
CAC0144 307 tf
CAC0183 307 tf
CAC0189 307 tf
CAC0402 307 tf
CAC0951 307 tf
CAC1766 307 tf
CAC1915 307 tf
CAC2236 307 tf
CAC2471 307 tf
CAC3472 307 tf
CAC3475 307 tf

Warning: CAC1531 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
6930 1.10e+03 gggGAGgaAatGtGc
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6931 1.60e+03 gaAgcCAtcc
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7266 3.10e-02 atGgagaTGa
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7267 1.90e+03 GGAGCG
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for CAC1531

CAC1531 is enriched for 3 functions in 3 categories.
Enrichment Table (3)
Function System
Uncharacterized conserved protein cog/ cog
signal transducer activity go/ molecular_function
signal transduction go/ biological_process
Module neighborhood information for CAC1531

CAC1531 has total of 27 gene neighbors in modules 139, 307
Gene neighbors (27)
Gene Common Name Description Module membership
CAC0370 CAC0370 Cation efflux system protein, AcrB/AcrF/AcrD family (NCBI ptt file) 171, 307
CAC0817 CAC0817 Hypothetical protein (NCBI ptt file) 139, 181
CAC0913 CAC0913 Possible non-processive endoglucanase family 9, secreted; CelG ortholog; dockerin and cellulose-binding domain (NCBI ptt file) 161, 307
CAC0919 CAC0919 Probably secreted sialidase; several ASP-boxes and dockerin domain (NCBI ptt file) 161, 307
CAC0960 CAC0960 Predicted xylanase related protein (NCBI ptt file) 125, 307
CAC1087 CAC1087 Hypothetical protein (NCBI ptt file) 139, 272
CAC1191 CAC1191 Hypothetical protein (NCBI ptt file) 104, 307
CAC1447 CAC1447 MDR-type permease, probably tetracycline resistance protein (NCBI ptt file) 141, 307
CAC1498 CAC1498 Predicted flavoprotein (NCBI ptt file) 46, 307
CAC1524 CAC1524 Methyl-accepting chemotaxis-like domain (chemotaxis sensory transducer) (NCBI ptt file) 139, 181
CAC1531 CAC1531 Uncharacterized conserved protein (NCBI ptt file) 139, 307
CAC1534 CAC1534 Predicted permease (NCBI ptt file) 307, 347
CAC1649 CAC1649 Hypothetical protein, CF-7 family. Related to CAC1969 (NCBI ptt file) 46, 307
CAC1862 CAC1862 Hypothetical protein (NCBI ptt file) 171, 307
CAC1932 CAC1932 Hypothetical protein (NCBI ptt file) 139, 181
CAC1933 dnaL DNA replication protein DnaC (NCBI ptt file) 139, 181
CAC1935 CAC1935 Hypothetical protein (NCBI ptt file) 139, 175
CAC1940 CAC1940 Hypothetical protein (NCBI ptt file) 139, 181
CAC1941 abrB Transcription regulator AbrB (NCBI ptt file) 139, 181
CAC2045 CAC2045 Secreted protein containing domain of murein hydrolase (MLTA homolog) (NCBI ptt file) 161, 307
CAC2135 CAC2135 ATP-dependent serine protease LA/LON family (NCBI ptt file) 127, 139
CAC2463 CAC2463 Hypothetical protein, CF-13 family (NCBI ptt file) 139, 181
CAC2510 CAC2510 Predicted membrane protein (NCBI ptt file) 139, 181
CAC2598 CAC2598 Uncharacterized protein, homolog of ywsA B.subtilis (NCBI ptt file) 139, 181
CAC2621 CAC2621 Cell wall hydrolase (autolysin), family 25 of glycosyl hydrolases; peptodoglycan-binding domain (NCBI ptt file) 139, 181
CAC2717 CAC2717 Ethanolamine ammonia lyase small subunit (NCBI ptt file) 124, 139
CAC3316 CAC3316 Possible cardiolipin synthase (phospholipase D family) (NCBI ptt file) 46, 307
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for CAC1531
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend