Organism : Clostridium acetobutylicum | Module List :
Regulation information for CAC2711(Mouseover regulator name to see its description)
Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
|Motif Id||e-value||Consensus||Motif Logo|
Functional Enrichment for CAC2711
Module neighborhood information for CAC2711
|Gene||Common Name||Description||Module membership|
|CAC0115||CAC0115||Uncharacterized protein, Yje/RRF2 family (NCBI ptt file)||63, 232|
|CAC0322||CAC0322||Sensory protein, containing EAL-domain (NCBI ptt file)||232, 295|
|CAC0493||CAC0493||Uncharcterized small conserved protein, YhhG family (NCBI ptt file)||64, 232|
|CAC0494||CAC0494||PemK family of DNA-binding proteins (NCBI ptt file)||32, 232|
|CAC0748||CAC0748||Nitroreductase family protein (NCBI ptt file)||154, 255|
|CAC1242||mreB||mreB (NCBI ptt file)||35, 255|
|CAC1289||CAC1289||Uncharacterized conserved protein, YqeY B.subtilis ortholog (NCBI ptt file)||32, 232|
|CAC1745||rpmF||Ribosomal protein L32 (NCBI ptt file)||32, 232|
|CAC1747||acpA||Acyl carrier protein, ACP (NCBI ptt file)||32, 232|
|CAC2710||etfB||Electron transfer flavoprotein beta-subunit (NCBI ptt file)||255, 259|
|CAC2711||bcd||Butyryl-CoA dehydrogenase (NCBI ptt file)||232, 255|
|CAC2712||crt||Crotonase (3-hydroxybutyryl-COA dehydratase) (NCBI ptt file)||61, 232|
|CAC2856||metK||S-adenosylmethionine synthetase (NCBI ptt file)||32, 232|
|CAC3004||folA||Dihydrofolate reductase (NCBI ptt file)||255, 258|
|CAC3087||CAC3087||Phosphoenolpyruvate-protein kinase (PTS system enzyme I) (NCBI ptt file)||4, 255|
|CAC3099||truA||Pseudouridylate synthase, TRUA (NCBI ptt file)||106, 255|
|CAC3101||CAC3101||ABC-type transporter, ATPase component (cobalt transporters subfamily) (NCBI ptt file)||79, 255|
|CAC3102||CAC3102||ABC-type transporter, ATPase component (cobalt transporters subfamily) (NCBI ptt file)||255, 358|
|CAC3107||rpsM||Ribosomal protein S13 (NCBI ptt file)||255, 358|
|CAC3109||infA||Translation initiation factor IF-1 (NCBI ptt file)||255, 292|
|CAC3110||CAC3110||Ribosomal protein L14E (archaeal/eukaryotic type) (NCBI ptt file)||255, 358|
|CAC3118||rplF||Ribosomal protein L6 (NCBI ptt file)||255, 358|
|CAC3122||rplX||Ribosomal protein L24 (NCBI ptt file)||255, 304|
|CAC3125||rpmC||Ribosomal protein L29 (NCBI ptt file)||255, 358|
|CAC3129||rpsS||Ribosomal protein S19 (NCBI ptt file)||237, 255|
|CAC3131||rplW||Ribosomal protein L23 (NCBI ptt file)||116, 255|
|CAC3133||rplC||Ribosomal protein L3 (NCBI ptt file)||254, 255|
|CAC3135||CAC3135||Uncharacterized C4-type Zn-finger containing protein (NCBI ptt file)||232, 237|
|CAC3142||rpoC||DNA-dependent RNA polymerase beta' subunit (NCBI ptt file)||255, 335|
|CAC3143||rpoB||DNA-dependent RNA polymerase beta subunit (NCBI ptt file)||255, 335|
|CAC3145||rplL||Ribosomal protein L7/L12 (NCBI ptt file)||61, 232|
|CAC3147||rplA||Ribosomal protein L1 (NCBI ptt file)||61, 232|
|CAC3149||nusG||Transcription antiterminator NusG (NCBI ptt file)||116, 255|
|CAC3150||secE||Preprotein translocase subunit SecE (NCBI ptt file)||116, 232|
|CAC3151||rpmG||L33 (NCBI ptt file)||5, 255|
|CAC3222||gcaD||UDP-N-acetylglucosamine pyrophosphorylase (NCBI ptt file)||255, 312|
|CAC3224||purR||PUR operon repressor, Adenine/guanine phosphoribosyltransferase family (NCBI ptt file)||232, 292|
|CAC3252||proC||Pyrroline-5-carboxylate reductase (NCBI ptt file)||85, 232|
|CAC3394||CAC3394||Uncharacterized conserved protein, YGIN family (NCBI ptt file)||232, 292|
Gene Page Help
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
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Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.
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Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.
Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
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CircVisOur circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
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