Organism : Clostridium acetobutylicum
| Module List :
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CAC2868 atpH
FoF1-type ATP synthase delta subunit (NCBI ptt file)
Functional Annotations (7)
Function | System |
---|---|
F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) | cog/ cog |
hydrogen-transporting two-sector ATPase activity | go/ molecular_function |
ATP synthesis coupled proton transport | go/ biological_process |
proton-transporting ATP synthase complex | go/ cellular_component |
hydrogen ion transporting ATP synthase activity, rotational mechanism | go/ molecular_function |
proton-transporting ATPase activity, rotational mechanism | go/ molecular_function |
ATP_synt_delta | tigr/ tigrfam |
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Regulation information for CAC2868
(Mouseover regulator name to see its description)
Regulator | Module | Operator |
---|---|---|
CAC0465 | 59 | tf |
CAC0951 | 59 | tf |
CAC0977 | 59 | tf |
CAC1300 | 59 | tf |
CAC1320 | 59 | tf |
CAC1536 | 59 | tf |
CAC1719 | 59 | tf |
CAC2608 | 59 | tf |
CAC2934 | 59 | tf |
CAC3104 | 59 | tf |
CAC3149 | 59 | tf |
CAC3192 | 59 | tf |
CAC0162 | 335 | tf |
CAC0707 | 335 | tf |
CAC0863 | 335 | tf |
CAC0933 | 335 | tf |
CAC1032 | 335 | tf |
CAC1300 | 335 | tf |
CAC1320 | 335 | tf |
CAC1832 | 335 | tf |
CAC2430 | 335 | tf |
CAC3142 | 335 | tf |
CAC3149 | 335 | tf |
CAC3199 | 335 | tf |
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Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
Motif Id | e-value | Consensus | Motif Logo |
---|---|---|---|
6772 | 1.30e+01 | gTGGAGG |
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6773 | 3.80e+03 | AAgGatTG.Ag |
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7322 | 1.20e-05 | gGAGAGGatG |
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7323 | 9.80e+02 | GCCTTCACcCC |
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Functional Enrichment for CAC2868
Function | System |
---|---|
F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) | cog/ cog |
hydrogen-transporting two-sector ATPase activity | go/ molecular_function |
ATP synthesis coupled proton transport | go/ biological_process |
proton-transporting ATP synthase complex | go/ cellular_component |
hydrogen ion transporting ATP synthase activity, rotational mechanism | go/ molecular_function |
proton-transporting ATPase activity, rotational mechanism | go/ molecular_function |
ATP_synt_delta | tigr/ tigrfam |
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Module neighborhood information for CAC2868
Gene | Common Name | Description | Module membership |
---|---|---|---|
CAC0013 | CAC0013 | Uncharacterized small conserved protein, ortholog of T.maritima (4981999) and P.abyssi (5457704) (NCBI ptt file) | 59, 253 |
CAC0502 | uvrB | Excinuclease ABC subunit B (helicase subunit of the DNA excision repair complex) (NCBI ptt file) | 154, 335 |
CAC0503 | uvrA | Excinuclease ABC subunit A (ATP-ase), (uvrA) (NCBI ptt file) | 154, 335 |
CAC0680 | CAC0680 | Predicted membrane protein (NCBI ptt file) | 52, 59 |
CAC0710 | pgk | 3-phosphoglycerate kinase (NCBI ptt file) | 79, 335 |
CAC1065 | CAC1065 | Uncharacterized protein, related stage III sporulation protein AH of Bacillus sp. (NCBI ptt file) | 59, 304 |
CAC1538 | CAC1538 | Predicted permease, YCXC B.subtilis ortholog (NCBI ptt file) | 59, 151 |
CAC1735 | CAC1735 | Predicted kinase related to hydroxyacetone kinase, YLOV ortholog (NCBI ptt file) | 36, 335 |
CAC1740 | CAC1740 | Uncharcaterized membrane protein, YLBJ B.subtilis homolog (NCBI ptt file) | 59, 304 |
CAC1743 | askA | Acetate kinase (NCBI ptt file) | 335, 343 |
CAC1744 | CAC1744 | Predicted Zn-finger-like protein, possible nucleic acid binding (NCBI ptt file) | 59, 61 |
CAC1748 | rncS | DsRNA-specific ribonuclease III (NCBI ptt file) | 271, 335 |
CAC1787 | rpsB | Ribosomal protein S2 (NCBI ptt file) | 59, 61 |
CAC2229 | CAC2229 | Pyruvate:ferredoxin oxidoreductase (NCBI ptt file) | 59, 63 |
CAC2409 | CAC2409 | Transglutaminase-like enzyme, putative cysteine protease (NCBI ptt file) | 59, 105 |
CAC2411 | CAC2411 | Zn-dependent protease of MPP family (NCBI ptt file) | 105, 335 |
CAC2656 | CAC2656 | Protein containing uncharacterized domain from NimC family (NCBI ptt file) | 59, 296 |
CAC2657 | CAC2657 | Polyferredoxin (NCBI ptt file) | 59, 296 |
CAC2709 | etfA | Electron transfer flavoprotein alpha-subunit (NCBI ptt file) | 10, 59 |
CAC2748 | deaD | ATP dependent RNA helicase DeaD, superfamily II (NCBI ptt file) | 59, 333 |
CAC2845 | prfB | Protein chain release factor B (NCBI ptt file) | 329, 335 |
CAC2855 | CAC2855 | Predicted membrane protein (NCBI ptt file) | 59, 76 |
CAC2864 | atpC | FoF1-type ATP synthase epsilon subunit (NCBI ptt file) | 304, 335 |
CAC2865 | atpD | FoF1-type ATP synthase beta subunit (NCBI ptt file) | 59, 304 |
CAC2866 | atpG | FoF1-type ATP synthase gamma subunit (NCBI ptt file) | 59, 335 |
CAC2867 | atpA | FoF1-type ATP synthase alpha subunit (NCBI ptt file) | 59, 335 |
CAC2868 | atpH | FoF1-type ATP synthase delta subunit (NCBI ptt file) | 59, 335 |
CAC2869 | atpF | FoF1-type ATP synthase B subunit (NCBI ptt file) | 79, 335 |
CAC2870 | atpE | FoF1-type ATP synthase C subunit (NCBI ptt file) | 59, 304 |
CAC2871 | atpB | FoF1-type ATP synthase A subunit (NCBI ptt file) | 59, 79 |
CAC2887 | tdk | Thymidine kinase (NCBI ptt file) | 59, 337 |
CAC2896 | CAC2896 | Uncharacterized protein, YPEB B.subtilis ortholog (NCBI ptt file) | 59, 179 |
CAC3017 | CAC3017 | Predicted xylanase/chitin deacetylase (NCBI ptt file) | 36, 335 |
CAC3103 | rplQ | Ribosomal protein L17 (NCBI ptt file) | 20, 59 |
CAC3106 | rpsK | Ribosomal protein S11 (NCBI ptt file) | 59, 362 |
CAC3112 | adk | Adenylate kinase (NCBI ptt file) | 335, 362 |
CAC3114 | rplO | Ribosomal protein L15 (NCBI ptt file) | 59, 335 |
CAC3120 | rpsN | Ribosomal protein S14 (NCBI ptt file) | 335, 362 |
CAC3121 | rplE | Ribosomal protein L5 (NCBI ptt file) | 59, 241 |
CAC3136 | tufA | Elongation Factor Tu (Ef-Tu) (NCBI ptt file) | 78, 335 |
CAC3138 | fus | Translation elongation factor EF-G (NCBI ptt file) | 36, 335 |
CAC3142 | rpoC | DNA-dependent RNA polymerase beta' subunit (NCBI ptt file) | 255, 335 |
CAC3143 | rpoB | DNA-dependent RNA polymerase beta subunit (NCBI ptt file) | 255, 335 |
CAC3215 | prsA | Parvulin-like peptidyl-prolyl isomerase, PRSA B.subtilis ortholog (NCBI ptt file) | 53, 59 |
CAC3437 | CAC3437 | Predicted membrane-associated Zn-dependent protease, HtpX family (BlaR subfamily) (NCBI ptt file) | 59, 253 |
CAC3563 | CAC3563 | Mismatch repair protein MutS-like ATPase (NCBI ptt file) | 247, 335 |
CAC3715 | dnaC | Replicative DNA helicase, DNAC (NCBI ptt file) | 243, 335 |
Gene Page Help
Network Tab
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
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Regulation Tab
Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.
You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".
For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.
Motifs Tab
Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Functions Tab
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.
Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
Help Tab
This help page. More general help can be accessed by clicking help menu in the main navigation bar.
CircVis
Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;![](/static/images/help_images/circvis-help.png)
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
- 2. Source gene
- 3. Target genes (other module members)
- 4. Interactions between source and target genes for a particular module
- 5. Module(s) that source gene and target genes belong to
- 6. Visualisation legend
Social Tab
Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.
Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.
In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.