Organism : Campylobacter jejuni
| Module List :
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Cj0355c
two-component regulator (NCBI ptt file)
Functional Annotations (5)
Function | System |
---|---|
Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain | cog/ cog |
two-component response regulator activity | go/ molecular_function |
two-component signal transduction system (phosphorelay) | go/ biological_process |
DNA binding | go/ molecular_function |
regulation of transcription, DNA-dependent | go/ biological_process |
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Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
Motif Id | e-value | Consensus | Motif Logo |
---|---|---|---|
7494 | 1.70e+03 | AgCaaAGc |
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7495 | 3.90e+03 | cCCAaAAGCcCtAaaGGGc |
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7722 | 3.70e+03 | gcTcCggcA.CC |
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7723 | 6.30e+03 | GAGAAtTGGGG |
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Functional Enrichment for Cj0355c
Function | System |
---|---|
Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain | cog/ cog |
two-component response regulator activity | go/ molecular_function |
two-component signal transduction system (phosphorelay) | go/ biological_process |
DNA binding | go/ molecular_function |
regulation of transcription, DNA-dependent | go/ biological_process |
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Module neighborhood information for Cj0355c
Gene | Common Name | Description | Module membership |
---|---|---|---|
Cj0011c | Cj0011c | putative non-specific DNA binding protein (NCBI ptt file) | 87, 170 |
Cj0020c | Cj0020c | cytochrome C551 peroxidase (NCBI ptt file) | 137, 170 |
Cj0162c | Cj0162c | putative periplasmic protein (NCBI ptt file) | 56, 81 |
Cj0238 | Cj0238 | putative integral membrane protein (NCBI ptt file) | 56, 94 |
Cj0332c | ndk | nucleoside diphosphate kinase (NCBI ptt file) | 74, 170 |
Cj0355c | Cj0355c | two-component regulator (NCBI ptt file) | 56, 170 |
Cj0374 | Cj0374 | hypothetical protein Cj0374 (NCBI ptt file) | 13, 56 |
Cj0375 | Cj0375 | putative lipoprotein (NCBI ptt file) | 13, 56 |
Cj0382c | nusB | transcription termination protein (NCBI ptt file) | 52, 56 |
Cj0384c | kdsA | 2-dehydro-3-deoxyphosphooctonate aldolase (NCBI ptt file) | 142, 170 |
Cj0400 | fur | ferric uptake regulator (NCBI ptt file) | 83, 170 |
Cj0403 | Cj0403 | hypothetical protein Cj0403 (NCBI ptt file) | 127, 170 |
Cj0404 | Cj0404 | putative transmembrane protein (NCBI ptt file) | 98, 170 |
Cj0463 | Cj0463 | zinc protease-like protein (NCBI ptt file) | 56, 120 |
Cj0467 | Cj0467 | amino-acid ABC transporter integral membrane protein (NCBI ptt file) | 56, 81 |
Cj0527c | flgC | flagellar basal-body rod protein (NCBI ptt file) | 142, 170 |
Cj0612c | cft | ferritin (NCBI ptt file) | 142, 170 |
Cj0638c | ppa | inorganic pyrophosphatase (NCBI ptt file) | 87, 170 |
Cj0639c | adk | adenylate kinase (NCBI ptt file) | 166, 170 |
Cj0640c | aspS | aspartyl-tRNA synthetase (NCBI ptt file) | 56, 170 |
Cj0643 | Cj0643 | putative two-component response regulator (NCBI ptt file) | 34, 56 |
Cj0654c | Cj0654c | None | 56, 132 |
Cj0662c | hslU | putative heat shock protein (NCBI ptt file) | 137, 170 |
Cj0704 | glyQ | glycyl-tRNA synthetase alpha chain (NCBI ptt file) | 56, 158 |
Cj0782 | napH | putative ferredoxin (NCBI ptt file) | 49, 170 |
Cj0883c | Cj0883c | hypothetical protein Cj0883c (NCBI ptt file) | 56, 114 |
Cj0917c | cstA | carbon starvation protein A homolog (NCBI ptt file) | 56, 158 |
Cj0969 | Cj0969 | None | 47, 56 |
Cj1010 | tgt | queuine tRNA-ribosyltransferase (NCBI ptt file) | 56, 122 |
Cj1084c | Cj1084c | putative ATP/GTP-binding protein (NCBI ptt file) | 56, 65 |
Cj1096c | metK | S-adenosylmethionine synthetase (NCBI ptt file) | 137, 170 |
Cj1216c | Cj1216c | hypothetical protein Cj1216c (NCBI ptt file) | 26, 56 |
Cj1248 | guaA | GMP synthase (glutamine-hydrolyzing) (NCBI ptt file) | 98, 170 |
Cj1265c | hydC | Ni/Fe-hydrogenase B-type cytochrome subunit (NCBI ptt file) | 74, 170 |
Cj1267c | hydA | Ni/Fe-hydrogenase small chain (NCBI ptt file) | 52, 170 |
Cj1273c | rpoZ | putative DNA-directed RNA polymerase omega chain (NCBI ptt file) | 142, 170 |
Cj1274c | pyrH | uridylate kinase (NCBI ptt file) | 142, 170 |
Cj1277c | Cj1277c | putative ABC transporter ATP-binding protein (NCBI ptt file) | 56, 69 |
Cj1306c | Cj1306c | hypothetical protein Cj1306c (617 family) (NCBI ptt file) | 56, 120 |
Cj1320 | Cj1320 | putative aminotransferase (degT family) (NCBI ptt file) | 56, 125 |
Cj1362 | ruvB | holliday junction DNA helicase (NCBI ptt file) | 41, 56 |
Cj1455 | prfB | peptide chain release factor 2 (NCBI ptt file) | 56, 120 |
Cj1467 | Cj1467 | hypothetical protein Cj1467 (NCBI ptt file) | 28, 56 |
Cj1476c | Cj1476c | pyruvate-flavodoxin oxidoreductase (NCBI ptt file) | 137, 170 |
Cj1546 | Cj1546 | hypothetical protein Cj1546 (NCBI ptt file) | 56, 158 |
Cj1558 | Cj1558 | putative membrane protein (NCBI ptt file) | 66, 170 |
Cj1580c | Cj1580c | putative peptide ABC-transport system ATP-binding protein (NCBI ptt file) | 56, 128 |
Cj1583c | Cj1583c | putative peptide ABC-transport system permease protein (NCBI ptt file) | 23, 56 |
Cj1584c | Cj1584c | putative peptide ABC-transport system periplasmic peptide-binding protein (NCBI ptt file) | 56, 158 |
Cj1681c | cysQ | cysQ protein homolog (NCBI ptt file) | 56, 120 |
VIMSS47265 | VIMSS47265 | None | 56, 120 |
Gene Page Help
Network Tab
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.
Regulation Tab
Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.
You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".
For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.
Motifs Tab
Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Functions Tab
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.
Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
Help Tab
This help page. More general help can be accessed by clicking help menu in the main navigation bar.
CircVis
Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;![](/static/images/help_images/circvis-help.png)
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
- 2. Source gene
- 3. Target genes (other module members)
- 4. Interactions between source and target genes for a particular module
- 5. Module(s) that source gene and target genes belong to
- 6. Visualisation legend
Social Tab
Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.
Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.
In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.