Organism : Desulfovibrio vulgaris Hildenborough | Module List :
DVU0491

HDIG domain-containing protein

CircVis
Functional Annotations (3)
Function System
HD-GYP domain cog/ cog
catalytic activity go/ molecular_function
HDIG tigr/ tigrfam
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for DVU0491
(Mouseover regulator name to see its description)

DVU0491 is regulated by 16 influences and regulates 0 modules.
Regulators for DVU0491 (16)
Regulator Module Operator
DVU0529
DVU0569
178 combiner
DVU1331 178 tf
DVU2785
DVU3305
178 combiner
DVU2788
DVU3111
178 combiner
DVU2960
DVU2319
178 combiner
DVU0110 254 tf
DVU0230
DVU1745
254 combiner
DVU1063 254 tf
DVU1517 254 tf
DVU1572
DVU0110
254 combiner
DVU1788
DVU1517
254 combiner
DVU2567 254 tf
DVU2690 254 tf
DVU2802
DVU0230
254 combiner
DVU2802
DVU1788
254 combiner
DVU2909
DVU2690
254 combiner

Warning: DVU0491 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.
Click on the RegPredict links to explore the motif in RegPredict.

Motif Table (4)
Motif Id e-value Consensus Motif Logo RegPredict
339 5.10e+03 GgTGGt.A
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RegPredict
340 6.80e+03 AATGAT
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RegPredict
483 2.40e+02 TcCgGgGtGCGCc
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RegPredict
484 1.20e+04 aCtTCaGGagaa.G
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RegPredict
Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for DVU0491

DVU0491 is enriched for 3 functions in 3 categories.
Enrichment Table (3)
Function System
HD-GYP domain cog/ cog
catalytic activity go/ molecular_function
HDIG tigr/ tigrfam
Module neighborhood information for DVU0491

DVU0491 has total of 38 gene neighbors in modules 178, 254
Gene neighbors (38)
Gene Common Name Description Module membership
DVU0182 radical SAM domain-containing protein 65, 254
DVU0491 HDIG domain-containing protein 178, 254
DVU0574 None 226, 254
DVU0589 molybdopterin-guanine dinucleotide biosynthesis protein MobB/FeS domain-containing protein protein 178, 269
DVU1055 heptosyltransferase family protein 160, 254
DVU1066 gpt xanthine-guanine phosphoribosyltransferase 221, 254
DVU1221 hypothetical protein DVU1221 178, 224
DVU1258 glnN glutamine synthetase, type III 254, 270
DVU1284 priA primosomal protein n' 254, 305
DVU1390 hypothetical protein DVU1390 139, 254
DVU1394 hypothetical protein DVU1394 228, 254
DVU1395 C4-type zinc finger DksA/TraR family protein 65, 254
DVU1429 ychF GTP-dependent nucleic acid-binding protein EngD 254, 270
DVU1477 hypothetical protein DVU1477 233, 254
DVU1668 outer membrane lipoprotein carrier protein 46, 178
DVU1873 ppiB-2 peptidyl-prolyl cis-trans isomerase B 215, 254
DVU1933 PfpI family peptidase 166, 178
DVU2138 hypothetical protein DVU2138 105, 178
DVU2188 primase 183, 254
DVU2342 amino acid ABC transporter periplasmic amino acid-binding protein 178, 262
DVU2382 hypothetical protein DVU2382 155, 254
DVU2434 hypothetical protein DVU2434 230, 254
DVU2561 short chain dehydrogenase/reductase family oxidoreductase 254, 311
DVU2564 bioF 8-amino-7-oxononanoate synthase 34, 254
DVU2566 lysA-2 diaminopimelate decarboxylase 254, 311
DVU2641 lipoprotein 119, 254
DVU2642 alanyl-tRNA synthetase family protein 254, 305
DVU2971 glycosyl transferase family protein 103, 254
DVU3041 cytochrome c553 178, 274
DVU3118 hypothetical protein DVU3118 230, 254
DVU3123 HD domain-containing protein 254, 269
DVU3219 hypothetical protein DVU3219 211, 254
DVU3272 hypothetical protein 178, 251
DVU3279 cobT nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 254, 270
DVU3341 hypothetical protein DVU3341 252, 254
DVU3376 sulfatase family protein 238, 254
DVU3378 YbaK/EbsC protein 84, 254
DVUA0085 hypothetical protein DVUA0085 178, 179
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for DVU0491
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend