Organism : Desulfovibrio vulgaris Hildenborough | Module List :
DVU0638

hypothetical protein DVU0638

CircVis
Functional Annotations (0)

Warning: No Functional annotations were found!

GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for DVU0638
(Mouseover regulator name to see its description)

DVU0638 is regulated by 24 influences and regulates 0 modules.
Regulators for DVU0638 (24)
Regulator Module Operator
DVU0679 37 tf
DVU0744 37 tf
DVU1063 37 tf
DVU1340 37 tf
DVU1628 37 tf
DVU1949 37 tf
DVU2359 37 tf
DVU2547
DVU2582
37 combiner
DVU2547
DVU3229
37 combiner
DVU2934 37 tf
DVU3111 37 tf
DVU3167 37 tf
DVU3381 37 tf
DVUA0100 37 tf
DVU1754
DVU2989
14 combiner
DVU2423 14 tf
DVU2423
DVU2832
14 combiner
DVU2557
DVU2036
14 combiner
DVU2557
DVU3255
14 combiner
DVU2788
DVU3255
14 combiner
DVU2989
DVU2690
14 combiner
DVU3255 14 tf
DVUA0143 14 tf
DVUA0151
DVU2989
14 combiner

Warning: DVU0638 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.
Click on the RegPredict links to explore the motif in RegPredict.

Motif Table (4)
Motif Id e-value Consensus Motif Logo RegPredict
27 1.50e+02 acACcGGCcGCACaaCgGgaGact
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RegPredict
28 1.30e+03 CaT.CAagA.GaaA
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RegPredict
73 6.10e+03 ATtGCTaTCGT
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RegPredict
74 1.60e+04 CAtAtgacAGAaaCC
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RegPredict
Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for DVU0638

Warning: No Functional annotations were found!

Module neighborhood information for DVU0638

DVU0638 has total of 66 gene neighbors in modules 14, 37
Gene neighbors (66)
Gene Common Name Description Module membership
DVU0040 hypothetical protein DVU0040 37, 267
DVU0072 glucose-1-phosphate cytidylyl-transferase 14, 166
DVU0076 glycosyl transferase group 2 family protein 14, 251
DVU0080 fumC fumarate hydratase 14, 162
DVU0140 response regulator 37, 99
DVU0145 response regulator 37, 205
DVU0147 lipoprotein 37, 53
DVU0218 tail protein 37, 314
DVU0232 hypothetical protein DVU0232 37, 99
DVU0257 acetyltransferase 37, 69
DVU0301 hypothetical protein DVU0301 37, 330
DVU0328 glycosyl transferase group 1 family protein 14, 135
DVU0358 hypothetical protein DVU0358 37, 99
DVU0381 nhaC-1 Na+/H+ antiporter NhaC 37, 341
DVU0392 aromatic aminotransferase 37, 185
DVU0425 hypothetical protein DVU0425 14, 37
DVU0428 hypothetical protein DVU0428 14, 331
DVU0439 YCII-related domain-containing protein 14, 166
DVU0441 ade adenine deaminase 14, 48
DVU0478 serine/threonine protein phosphatase family protein 14, 150
DVU0638 hypothetical protein DVU0638 14, 37
DVU0639 pomB chemotaxis protein PomB 37, 205
DVU0641 hypothetical protein DVU0641 37, 225
DVU0680 sensory box histidine kinase 14, 291
DVU0691 hypothetical protein DVU0691 14, 135
DVU0699 None 14, 135
DVU0743 sensory box histidine kinase 14, 87
DVU1004 hypothetical protein DVU1004 14, 135
DVU1011 hypothetical protein DVU1011 37, 245
DVU1051 ccmE cytochrome c-type biogenesis protein CcmE 14, 249
DVU1064 aconitate hydratase 14, 146
DVU1126 lipoprotein 37, 267
DVU1360 galE UDP-glucose 4-epimerase 37, 342
DVU1423 lpdA 2-oxoglutarate dehydrogenase, E3 component, lipoamide dehydrogenase 14, 146
DVU1425 gcvPA glycine dehydrogenase subunit 1 14, 309
DVU1442 flagellin FlaG 37, 286
DVU1452 dtd D-tyrosyl-tRNA(Tyr) deacylase 14, 318
DVU1604 hypothetical protein DVU1604 37, 181
DVU1607 hypothetical protein DVU1607 14, 330
DVU1691 hypothetical protein DVU1691 37, 44
DVU1906 hypothetical protein DVU1906 37, 313
DVU1926 hypothetical protein DVU1926 14, 109
DVU1993 cation transporter E1-E2 family ATPase 37, 296
DVU2267 hypothetical protein DVU2267 37, 179
DVU2311 None 37, 261
DVU2473 hypothetical protein DVU2473 37, 46
DVU2498 hypothetical protein DVU2498 37, 342
DVU2551 HD domain-containing protein 37, 342
DVU2568 M20/M25/M40 family peptidase 14, 126
DVU2583 lipoprotein 14, 148
DVU2589 hypothetical protein DVU2589 37, 153
DVU2590 sensory box protein 37, 153
DVU2627 hypothetical protein DVU2627 14, 33
DVU2673 anaerobic glycerol-3-phosphate dehydrogenase subunit A, truncation 14, 268
DVU2779 ABC transporter solute-binding protein 14, 135
DVU2972 chemotaxis protein CheD 37, 274
DVU3021 HDIG domain-containing protein 37, 245
DVU3036 hypothetical protein DVU3036 37, 281
DVU3060 hypothetical protein DVU3060 37, 166
DVU3111 Crp/FNR family transcriptional regulator 37, 267
DVU3113 carA carbamoyl phosphate synthase small subunit 14, 249
DVU3127 pqiB paraquat-inducible protein B 14, 135
DVU3225 hypothetical protein DVU3225 37, 198
DVU3296 hypothetical protein DVU3296 14, 148
DVU3342 hypothetical protein DVU3342 37, 123
DVU3391 hypothetical protein DVU3391 37, 305
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for DVU0638
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend