Organism : Desulfovibrio vulgaris Hildenborough | Module List :
DVU1270

twitching motility protein

CircVis
Functional Annotations (6)
Function System
Tfp pilus assembly protein, pilus retraction ATPase PilT cog/ cog
ATP binding go/ molecular_function
intracellular go/ cellular_component
transport go/ biological_process
nucleoside-triphosphatase activity go/ molecular_function
pilT_fam tigr/ tigrfam
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for DVU1270
(Mouseover regulator name to see its description)

DVU1270 is regulated by 17 influences and regulates 0 modules.
Regulators for DVU1270 (17)
Regulator Module Operator
DVU2036
DVU2275
166 combiner
DVU2319
DVU0539
166 combiner
DVU2423 166 tf
DVU2423
DVU1964
166 combiner
DVU2423
DVU2675
166 combiner
DVU2644 166 tf
DVU0653
DVU2275
306 combiner
DVU1419 306 tf
DVU1547
DVUA0024
306 combiner
DVU1949 306 tf
DVU2036
DVU2275
306 combiner
DVU2423
DVU2832
306 combiner
DVU2423
DVU3381
306 combiner
DVU2547
DVU2588
306 combiner
DVU2547
DVU2832
306 combiner
DVU2547
DVU3142
306 combiner
DVU3381 306 tf

Warning: DVU1270 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.
Click on the RegPredict links to explore the motif in RegPredict.

Motif Table (4)
Motif Id e-value Consensus Motif Logo RegPredict
317 1.10e+04 GTCagtTGC.GTG.CgCA
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RegPredict
318 5.20e+04 agaAcGgCaGCGacG
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RegPredict
585 1.50e+02 TaattaA.A.AAggcatGCaAcgC
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RegPredict
586 1.40e+02 GTtGCgTg
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RegPredict
Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for DVU1270

DVU1270 is enriched for 6 functions in 3 categories.
Enrichment Table (6)
Function System
Tfp pilus assembly protein, pilus retraction ATPase PilT cog/ cog
ATP binding go/ molecular_function
intracellular go/ cellular_component
transport go/ biological_process
nucleoside-triphosphatase activity go/ molecular_function
pilT_fam tigr/ tigrfam
Module neighborhood information for DVU1270

DVU1270 has total of 55 gene neighbors in modules 166, 306
Gene neighbors (55)
Gene Common Name Description Module membership
DVU0015 lgt prolipoprotein diacylglyceryl transferase 166, 224
DVU0072 glucose-1-phosphate cytidylyl-transferase 14, 166
DVU0284 ppiB-1 peptidyl-prolyl cis-trans isomerase B 49, 166
DVU0438 AcrB/AcrD/AcrF family protein 166, 309
DVU0439 YCII-related domain-containing protein 14, 166
DVU0481 rfaD ADP-L-glycero-D-mannoheptose-6-epimerase 166, 176
DVU0764 hup-2 DNA-binding protein HU 166, 344
DVU0823 argJ bifunctional ornithine acetyltransferase/N-acetylglutamate synthase protein 84, 166
DVU0827 glycolate oxidase subunit GlcD 166, 291
DVU0828 smpB SsrA-binding protein 166, 291
DVU0830 ptsH phosphocarrier protein HPr 64, 166
DVU0836 trmD tRNA (guanine-N1)-methyltransferase 188, 306
DVU0867 aromatic amino acid decarboxylase 28, 306
DVU0931 thiD phosphomethylpyrimidine kinase 30, 306
DVU0956 rpsF 30S ribosomal protein S6 151, 306
DVU0966 amino acid ABC transporter periplasmic amino acid-binding protein 146, 306
DVU1046 hypothetical protein DVU1046 195, 306
DVU1049 ABC transporter ATP-binding protein 251, 306
DVU1065 peptidyl-prolyl cis-trans isomerse domain-containing protein 166, 206
DVU1069 branched chain amino acid ABC transporter permease 221, 306
DVU1186 mazG nucleoside triphosphate pyrophosphohydrolase 166, 230
DVU1236 amino acid ABC transporter ATP-binding protein 166, 228
DVU1237 His/Glu/Gln/Arg/opine ABC transporter permease 166, 306
DVU1249 fabD malonyl CoA-ACP transacylase 64, 306
DVU1270 twitching motility protein 166, 306
DVU1274 hypothetical protein DVU1274 64, 306
DVU1287 reductase, iron-sulfur binding subunit 151, 306
DVU1288 cytochrome c family protein 151, 306
DVU1289 reductase, iron-sulfur binding subunit 151, 306
DVU1344 ispG 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 166, 195
DVU1411 thiC thiamine biosynthesis protein ThiC 139, 306
DVU1608 ligA DNA ligase, NAD-dependent 139, 166
DVU1610 nadE glutamine-dependent NAD+ synthetase 166, 326
DVU1660 undecaprenyl pyrophosphate phosphatase 166, 228
DVU1746 C-5 cytosine-specific DNA methylase family protein 306, 331
DVU1848 hypothetical protein DVU1848 126, 306
DVU1900 hypothetical protein DVU1900 12, 306
DVU1933 PfpI family peptidase 166, 178
DVU1936 phosphonate ABC transporter ATP-binding protein 75, 306
DVU2113 xanthine/uracil permease 228, 306
DVU2285 L-lactate permease family protein 145, 306
DVU2335 hypothetical protein DVU2335 258, 306
DVU2523 lipoprotein 157, 166
DVU2533 pheT phenylalanyl-tRNA synthetase subunit beta 186, 306
DVU2553 NifU family protein 166, 258
DVU2582 TetR family transcriptional regulator 166, 337
DVU2677 sensor histidine kinase/response regulator 166, 172
DVU2683 L-lactate permease family protein 139, 166
DVU2748 cobM precorrin-4 C11-methyltransferase 166, 291
DVU2749 cobL precorrin-6Y C5,15-methyltransferase (decarboxylating) 166, 304
DVU2927 rplL 50S ribosomal protein L7/L12 151, 306
DVU2928 rpoB DNA-directed RNA polymerase subunit beta 151, 306
DVU2979 phosphatidylserine decarboxylase 103, 166
DVU3060 hypothetical protein DVU3060 37, 166
DVU3253 phenylacetate-coenzyme A ligase 230, 306
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for DVU1270
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend