Organism : Desulfovibrio vulgaris Hildenborough | Module List :
Regulation information for DVU1370(Mouseover regulator name to see its description)
Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
Click on the RegPredict links to explore the motif in RegPredict.
|Motif Id||e-value||Consensus||Motif Logo||RegPredict|
Module neighborhood information for DVU1370
|Gene||Common Name||Description||Module membership|
|DVU0084||aIF-2BI family translation initiation factor||9, 23|
|DVU0087||hypothetical protein DVU0087||9, 44|
|DVU0088||panF||sodium/panthothenate symporter||9, 69|
|DVU0091||hypothetical protein DVU0091||9, 327|
|DVU0110||sigma-54 dependent transcriptional regulator/response regulator||117, 141|
|DVU0141||M50 family peptidase||9, 223|
|DVU0142||trpS||tryptophanyl-tRNA synthetase||9, 180|
|DVU0156||ATP-dependent DNA helicase UvrD||117, 141|
|DVU0323||folD||bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase||9, 223|
|DVU0324||hypothetical protein DVU0324||9, 181|
|DVU0633||penicillin-binding protein||141, 176|
|DVU0651||hypothetical protein DVU0651||9, 334|
|DVU0682||DNA-binding protein||141, 229|
|DVU0794||fabI||enoyl-ACP reductase||9, 113|
|DVU0983||hypothetical protein DVU0983||35, 141|
|DVU1029||hisC||histidinol-phosphate aminotransferase||9, 223|
|DVU1181||response regulator||141, 279|
|DVU1185||colicin V production family protein||9, 180|
|DVU1189||hypothetical protein DVU1189||9, 277|
|DVU1369||hypothetical protein DVU1369||9, 126|
|DVU1370||hypothetical protein DVU1370||9, 141|
|DVU1459||hypothetical protein DVU1459||9, 334|
|DVU1540||purU||formyltetrahydrofolate deformylase||9, 223|
|DVU1544||mechanosensitive ion channel family protein||117, 141|
|DVU1581||hypothetical protein DVU1581||141, 294|
|DVU1860||lnt||apolipoprotein N-acyltransferase||9, 214|
|DVU1863||flagellar synthesis regulator FleN||9, 113|
|DVU2257||hypothetical protein DVU2257||9, 214|
|DVU2302||glutathione-regulated potassium-efflux system protein KefB||141, 277|
|DVU2320||3-octaprenyl-4-hydroxybenzoate carboxy-lyase||9, 316|
|DVU2330||MRP family protein||35, 141|
|DVU2338||HhH-GPD family DNA repair protein||117, 141|
|DVU2413||radical SAM domain-containing protein||141, 185|
|DVU2425||rarD||rarD protein||141, 195|
|DVU2461||oligopeptide ABC transporter permease||9, 69|
|DVU2463||recN||DNA repair protein RecN||23, 141|
|DVU2558||bioB||biotin synthase||9, 327|
|DVU2581||response regulator||141, 278|
|DVU2634||hypothetical protein DVU2634||5, 9|
|DVU2780||hypothetical protein DVU2780||69, 141|
|DVU2899||hypothetical protein DVU2899||141, 316|
|DVU2900||amidohydrolase family protein||83, 141|
|DVU2901||pyrB||aspartate carbamoyltransferase catalytic subunit||141, 344|
|DVU2932||hypothetical protein DVU2932||117, 141|
|DVU3086||cobB-2||cobyrinic acid a,c-diamide synthase||83, 141|
|DVU3087||cobH||precorrin-8X methylmutase||46, 141|
|DVU3097||outer membrane efflux protein||141, 249|
|DVU3216||sensor histidine kinase||117, 141|
|DVU3278||peptidase/PDZ domain-containing protein||83, 141|
|DVU3297||tryptophan-specific transport protein||9, 334|
Gene Page Help
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
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Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.
You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".
For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.
Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.
Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
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CircVisOur circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
- 2. Source gene
- 3. Target genes (other module members)
- 4. Interactions between source and target genes for a particular module
- 5. Module(s) that source gene and target genes belong to
- 6. Visualisation legend
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