Organism : Desulfovibrio vulgaris Hildenborough | Module List :
DVU1376 ilvB-2

acetolactate synthase large subunit, biosynthetic type

CircVis
Functional Annotations (14)
Function System
Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] cog/ cog
magnesium ion binding go/ molecular_function
acetolactate synthase activity go/ molecular_function
branched chain family amino acid biosynthetic process go/ biological_process
valine biosynthetic process go/ biological_process
thiamine pyrophosphate binding go/ molecular_function
flavin adenine dinucleotide binding go/ molecular_function
Valine leucine and isoleucine biosynthesis kegg/ kegg pathway
Butanoate metabolism kegg/ kegg pathway
C5-Branched dibasic acid metabolism kegg/ kegg pathway
Pantothenate and CoA biosynthesis kegg/ kegg pathway
Metabolic pathways kegg/ kegg pathway
Biosynthesis of secondary metabolites kegg/ kegg pathway
acolac_lg tigr/ tigrfam
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for DVU1376
(Mouseover regulator name to see its description)

DVU1376 is regulated by 24 influences and regulates 0 modules.
Regulators for DVU1376 ilvB-2 (24)
Regulator Module Operator
DVU0277
DVU0946
117 combiner
DVU0525 117 tf
DVU0653 117 tf
DVU0946 117 tf
DVU0946
DVU1760
117 combiner
DVU0946
DVU2956
117 combiner
DVU2788
DVU0946
117 combiner
DVU2832
DVU1745
117 combiner
DVU3023 117 tf
DVU3167 117 tf
DVU3167
DVU0916
117 combiner
DVU3186 117 tf
DVU3186
DVU0653
117 combiner
DVU0946 303 tf
DVU0946
DVU1144
303 combiner
DVU2114 303 tf
DVU2836
DVU3023
303 combiner
DVU3023 303 tf
DVU3167 303 tf
DVU3167
DVU2114
303 combiner
DVU3186 303 tf
DVU3186
DVU0110
303 combiner
DVU3193
DVU0946
303 combiner
DVU3255
DVU3186
303 combiner

Warning: DVU1376 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.
Click on the RegPredict links to explore the motif in RegPredict.

Motif Table (4)
Motif Id e-value Consensus Motif Logo RegPredict
225 7.20e+00 cttgtcatcgctGTA
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RegPredict
226 1.30e+02 cgaTGCgctGccg.a.cggCt
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RegPredict
579 1.30e-04 CA.gGTtTtttTacAgcaAtG
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RegPredict
580 3.60e+00 AAGATAAAATAACATCTTATTTAT
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RegPredict
Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for DVU1376

DVU1376 is enriched for 14 functions in 3 categories.
Module neighborhood information for DVU1376

DVU1376 has total of 41 gene neighbors in modules 117, 303
Gene neighbors (41)
Gene Common Name Description Module membership
DVU0007 asnC asparaginyl-tRNA synthetase 35, 117
DVU0110 sigma-54 dependent transcriptional regulator/response regulator 117, 141
DVU0156 ATP-dependent DNA helicase UvrD 117, 141
DVU0326 hypE hydrogenase expression/formation protein HypE 117, 250
DVU0413 TrkH family potassium uptake protein 48, 117
DVU0612 STAS domain-containing protein 48, 117
DVU0656 hypothetical protein DVU0656 63, 303
DVU0657 HSP20 family protein 164, 303
DVU0713 branched-chain amino acid ABC transporter permease 303, 347
DVU0760 hypothetical protein DVU0760 35, 117
DVU0940 GGDEF domain-containing protein 214, 303
DVU1376 ilvB-2 acetolactate synthase large subunit, biosynthetic type 117, 303
DVU1461 hemA glutamyl-tRNA reductase 117, 334
DVU1462 cytochrome c assembly protein 117, 303
DVU1463 siroheme synthase 117, 334
DVU1464 heptosyltransferase family protein 117, 303
DVU1544 mechanosensitive ion channel family protein 117, 141
DVU1650 hypothetical protein DVU1650 300, 303
DVU1651 hypothetical protein DVU1651 128, 303
DVU1682 GAF domain-containing protein 163, 303
DVU1883 hypothetical protein DVU1883 117, 249
DVU2140 tmk thymidylate kinase 117, 268
DVU2323 hypothetical protein DVU2323 164, 303
DVU2329 hypB hydrogenase accessory protein HypB 35, 117
DVU2338 HhH-GPD family DNA repair protein 117, 141
DVU2491 ABC transporter ATP-binding protein 35, 117
DVU2608 motA-3 flagellar motor protein MotA 88, 303
DVU2765 metallo-beta-lactamase family protein 35, 117
DVU2766 hypothetical protein DVU2766 35, 117
DVU2767 iron-sulfur flavoprotein 35, 117
DVU2799 MarR family transcriptional regulator 272, 303
DVU2800 heavy metal translocating P-type ATPase 272, 303
DVU2801 hypothetical protein DVU2801 272, 303
DVU2932 hypothetical protein DVU2932 117, 141
DVU3009 radical SAM domain-containing protein 117, 176
DVU3067 hypF [NiFe] hydrogenase maturation protein HypF [Desulfovibrio vulgaris str. Hildenborough] 35, 117
DVU3085 hypothetical protein DVU3085 88, 303
DVU3172 hypothetical protein DVU3172 35, 117
DVU3216 sensor histidine kinase 117, 141
DVU3261 frdC fumarate reductase, cytochrome subunit B 48, 303
DVU3356 NAD-dependent epimerase/dehydratase family protein 268, 303
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for DVU1376
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend