Organism : Desulfovibrio vulgaris Hildenborough | Module List :
DVU1753

hypothetical protein DVU1753

CircVis
Functional Annotations (0)

Warning: No Functional annotations were found!

GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for DVU1753
(Mouseover regulator name to see its description)

DVU1753 is regulated by 17 influences and regulates 0 modules.
Regulators for DVU1753 (17)
Regulator Module Operator
DVU1517 242 tf
DVU1517
DVU0539
242 combiner
DVU1754 242 tf
DVU1754
DVU3305
242 combiner
DVU2588
DVU1967
242 combiner
DVU3142 242 tf
DVU3255
DVU3186
242 combiner
DVU0030
DVU2567
118 combiner
DVU1063 118 tf
DVU1517 118 tf
DVU1518
DVU2195
118 combiner
DVU1561
DVUA0024
118 combiner
DVU1561
DVUA0143
118 combiner
DVU1754 118 tf
DVU2785
DVU3142
118 combiner
DVU2832 118 tf
DVUA0024
DVU0529
118 combiner

Warning: DVU1753 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.
Click on the RegPredict links to explore the motif in RegPredict.

Motif Table (4)
Motif Id e-value Consensus Motif Logo RegPredict
227 1.50e+04 CgTTgC
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RegPredict
228 3.80e+04 ATGAAA
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RegPredict
461 0.00e+00 aa.TcTctGcAtaaGaaAaAtAat
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RegPredict
462 1.30e-03 ATTaccTCCaTCtCAcGGGaA
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RegPredict
Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for DVU1753

Warning: No Functional annotations were found!

Module neighborhood information for DVU1753

DVU1753 has total of 32 gene neighbors in modules 118, 242
Gene neighbors (32)
Gene Common Name Description Module membership
DVU0609 lipoprotein 19, 118
DVU1098 adenine specific DNA methyltransferase 118, 244
DVU1110 hypothetical protein DVU1110 118, 239
DVU1162 hypothetical protein DVU1162 80, 242
DVU1356 HD domain-containing protein 84, 118
DVU1414 sensory box protein 242, 299
DVU1550 phosphoglycerate mutase family protein 242, 322
DVU1551 HD domain-containing protein 242, 322
DVU1552 hypothetical protein DVU1552 77, 242
DVU1553 AMP-binding protein 242, 322
DVU1554 radical SAM domain-containing protein 110, 242
DVU1555 hypothetical protein DVU1555 242, 322
DVU1556 hypothetical protein DVU1556 242, 322
DVU1557 hypothetical protein DVU1557 242, 322
DVU1558 hypothetical protein DVU1558 242, 322
DVU1559 mop aldehyde oxidoreductase 77, 242
DVU1560 molybdopterin biosynthesis protein 242, 322
DVU1561 molybdenum-binding protein 242, 263
DVU1598 hypothetical protein DVU1598 86, 118
DVU1702 hypothetical protein DVU1702 79, 118
DVU1703 type I restriction-modification enzyme, R subunit 118, 270
DVU1753 hypothetical protein DVU1753 118, 242
DVU1755 hypothetical protein DVU1755 118, 133
DVU1871 aspA aspartate ammonia-lyase 79, 118
DVU2132 hypothetical protein DVU2132 118, 138
DVU2133 hypothetical protein DVU2133 118, 138
DVU2196 hypothetical protein DVU2196 85, 118
DVU2207 hypothetical protein DVU2207 118, 243
DVU2270 hypothetical protein DVU2270 97, 118
DVU2773 hypothetical protein DVU2773 242, 326
DVU2774 hypothetical protein 208, 242
DVU2808 TonB domain-containing protein 7, 118
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for DVU1753
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend