Organism : Desulfovibrio vulgaris Hildenborough | Module List :
DVU1911
CBS domain-containing protein
Functional Annotations (3)
Function | System |
---|---|
Predicted transcriptional regulator with C-terminal CBS domains | cog/ cog |
catalytic activity | go/ molecular_function |
metabolic process | go/ biological_process |
Regulation information for DVU1911
(Mouseover regulator name to see its description)
Regulator | Module | Operator |
---|---|---|
DVU0653 DVU1690 |
292 | combiner |
DVU0682 DVU2532 |
292 | combiner |
DVU1402 | 292 | tf |
DVU1517 | 292 | tf |
DVU1518 DVU0744 |
292 | combiner |
DVU1518 DVU2086 |
292 | combiner |
DVU1561 | 292 | tf |
DVU2086 DVU0744 |
292 | combiner |
DVU2532 DVU0653 |
292 | combiner |
DVU2532 DVU0679 |
292 | combiner |
DVU2532 DVU1949 |
292 | combiner |
DVU2644 | 292 | tf |
DVU2644 DVU0619 |
292 | combiner |
DVU3167 | 292 | tf |
DVU0682 DVU3255 |
251 | combiner |
DVU1518 DVU2086 |
251 | combiner |
DVU1561 | 251 | tf |
DVU2086 DVU1547 |
251 | combiner |
DVU2086 DVU3142 |
251 | combiner |
DVU2423 DVU2832 |
251 | combiner |
DVU2582 | 251 | tf |
DVU3167 DVU2582 |
251 | combiner |
DVU3255 DVU0110 |
251 | combiner |
Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
Click on the RegPredict links to explore the motif in RegPredict.
Motif Id | e-value | Consensus | Motif Logo | RegPredict |
---|---|---|---|---|
479 | 4.30e+02 | CAatTttccGcaA.A | RegPredict | |
480 | 1.70e+04 | A.ATcCTGCTcGAA | RegPredict | |
559 | 1.60e-01 | aAAGccCCgtgctcgCatc.gGCA | RegPredict | |
560 | 5.90e+00 | acAaactcgTgATtTtcgG | RegPredict |
Functional Enrichment for DVU1911
Function | System |
---|---|
Predicted transcriptional regulator with C-terminal CBS domains | cog/ cog |
catalytic activity | go/ molecular_function |
metabolic process | go/ biological_process |
Module neighborhood information for DVU1911
Gene | Common Name | Description | Module membership |
---|---|---|---|
DVU0075 | aminotransferase | 95, 251 | |
DVU0076 | glycosyl transferase group 2 family protein | 14, 251 | |
DVU0293 | dksA/traR C4-type zinc finger family protein | 251, 331 | |
DVU0341 | 3-deoxy-manno-octulosonate cytidylyltransferase | 251, 292 | |
DVU0398 | HMGL-like domain-containing protein | 236, 292 | |
DVU0400 | hypothetical protein DVU0400 | 185, 292 | |
DVU0402 | dsvA | dissimilatory sulfite reductase subunit alpha | 292, 348 |
DVU0403 | dvsB | dissimilatory sulfite reductase subunit beta | 292, 348 |
DVU0404 | dissimilatory sulfite reductase B | 292, 348 | |
DVU0751 | His/Glu/Gln/Arg/opine ABC transporter permease | 53, 292 | |
DVU0752 | amino acid ABC transporter amino acid-binding protein | 50, 292 | |
DVU0753 | amino acid ABC transporter ATP-binding protein | 235, 292 | |
DVU1045 | hypothetical protein DVU1045 | 52, 251 | |
DVU1047 | ccmC | cytochrome c-type biogenesis protein CcmC | 52, 251 |
DVU1048 | ccmB | cytochrome c-type biogenesis protein CcmB | 12, 251 |
DVU1049 | ABC transporter ATP-binding protein | 251, 306 | |
DVU1070 | branched chain amino acid ABC transporter ATP-binding protein | 221, 251 | |
DVU1094 | argH | argininosuccinate lyase | 220, 251 |
DVU1199 | ribAB | 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II | 248, 292 |
DVU1286 | reductase, transmembrane subunit | 52, 251 | |
DVU1314 | rplX | 50S ribosomal protein L24 | 248, 292 |
DVU1531 | methyltransferase | 26, 292 | |
DVU1586 | thioredoxin family protein | 292, 294 | |
DVU1623 | pyrG | CTP synthetase | 248, 292 |
DVU1624 | kdsA | 2-dehydro-3-deoxyphosphooctonate aldolase | 188, 292 |
DVU1625 | YrbI family phosphatase | 188, 292 | |
DVU1658 | translaldolase | 6, 251 | |
DVU1842 | lipoprotein | 186, 251 | |
DVU1866 | hypothetical protein DVU1866 | 292, 294 | |
DVU1907 | ugd | UDP-glucose 6-dehydrogenase | 65, 251 |
DVU1911 | CBS domain-containing protein | 251, 292 | |
DVU2226 | acetyl-CoA carboxylase, biotin carboxylase | 248, 292 | |
DVU2369 | lpxD | UDP-3-O-(R-3-hydroxymyristoyl)-glucosamine N-acyltransferase | 174, 251 |
DVU2531 | rpe | ribulose-phosphate 3-epimerase | 186, 292 |
DVU2534 | pheS | phenylalanyl-tRNA synthetase subunit alpha | 186, 292 |
DVU2537 | infC | translation initiation factor IF-3 | 186, 292 |
DVU2538 | thrS | threonyl-tRNA synthetase | 18, 292 |
DVU2580 | response regulator | 145, 251 | |
DVU2886 | AraC family transcriptional regulator | 251, 304 | |
DVU2887 | hypothetical protein DVU2887 | 106, 251 | |
DVU3055 | ribonuclease | 221, 251 | |
DVU3056 | hypothetical protein DVU3056 | 78, 251 | |
DVU3163 | ABC transporter permease | 174, 251 | |
DVU3176 | UDP-glucose/GDP-mannose dehydrogenase family protein | 169, 292 | |
DVU3178 | hypothetical protein DVU3178 | 172, 292 | |
DVU3229 | fliA | RNA polymerase sigma factor for flagellar operon FliA | 251, 304 |
DVU3272 | hypothetical protein | 178, 251 |
Gene Page Help
Network Tab
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
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Regulation Tab
Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.
You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".
For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.
Motifs Tab
Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Functions Tab
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.
Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
Help Tab
This help page. More general help can be accessed by clicking help menu in the main navigation bar.
CircVis
Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
- 2. Source gene
- 3. Target genes (other module members)
- 4. Interactions between source and target genes for a particular module
- 5. Module(s) that source gene and target genes belong to
- 6. Visualisation legend
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In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.