Organism : Desulfovibrio vulgaris Hildenborough | Module List :
DVU2072 cheA-3

chemotaxis protein CheA

CircVis
Functional Annotations (11)
Function System
Chemotaxis protein histidine kinase and related kinases cog/ cog
protein histidine kinase activity go/ molecular_function
signal transducer activity go/ molecular_function
ATP binding go/ molecular_function
cytoplasm go/ cellular_component
chemotaxis go/ biological_process
signal transduction go/ biological_process
kinase activity go/ molecular_function
peptidyl-histidine phosphorylation go/ biological_process
Two-component system kegg/ kegg pathway
Bacterial chemotaxis kegg/ kegg pathway
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for DVU2072
(Mouseover regulator name to see its description)

DVU2072 is regulated by 18 influences and regulates 0 modules.
Regulators for DVU2072 cheA-3 (18)
Regulator Module Operator
DVU0230 289 tf
DVU0309 289 tf
DVU0529 289 tf
DVU0629 289 tf
DVU1754
DVU2802
289 combiner
DVU1754
DVU2989
289 combiner
DVU1967
DVU2989
289 combiner
DVU2036
DVU2251
289 combiner
DVU2359
DVU2690
289 combiner
DVU2359
DVUA0143
289 combiner
DVU0436
DVU0230
102 combiner
DVU0525 102 tf
DVU1754 102 tf
DVU2036
DVU2633
102 combiner
DVU2423
DVU3142
102 combiner
DVU2588 102 tf
DVU3080
DVU0653
102 combiner
DVU3167 102 tf

Warning: DVU2072 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.
Click on the RegPredict links to explore the motif in RegPredict.

Motif Table (4)
Motif Id e-value Consensus Motif Logo RegPredict
197 1.90e+01 GCGcATGGCAtgAA
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RegPredict
198 1.30e+02 AgGtcGTTTTC
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RegPredict
553 1.00e-06 acatgcaTgacAtAtGct.cc
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RegPredict
554 1.80e+01 cggcaTcaagagCAT
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RegPredict
Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for DVU2072

DVU2072 is enriched for 11 functions in 3 categories.
Enrichment Table (11)
Function System
Chemotaxis protein histidine kinase and related kinases cog/ cog
protein histidine kinase activity go/ molecular_function
signal transducer activity go/ molecular_function
ATP binding go/ molecular_function
cytoplasm go/ cellular_component
chemotaxis go/ biological_process
signal transduction go/ biological_process
kinase activity go/ molecular_function
peptidyl-histidine phosphorylation go/ biological_process
Two-component system kegg/ kegg pathway
Bacterial chemotaxis kegg/ kegg pathway
Module neighborhood information for DVU2072

DVU2072 has total of 40 gene neighbors in modules 102, 289
Gene neighbors (40)
Gene Common Name Description Module membership
DVU0093 glycosyl transferase domain-containing protein 119, 289
DVU0094 methyl-accepting chemotaxis protein 247, 289
DVU0525 MarR family transcriptional regulator 227, 289
DVU0610 hypothetical protein DVU0610 85, 102
DVU0673 hypothetical protein DVU0673 70, 289
DVU0675 amino acid ABC transporter periplasmic amino acid-binding protein 102, 217
DVU1052 CBS domain-containing protein 102, 124
DVU1059 aminotransferase 102, 243
DVU1153 hypothetical protein DVU1153 106, 289
DVU1154 hypothetical protein DVU1154 179, 289
DVU1234 hypothetical protein DVU1234 102, 217
DVU1641 hypothetical protein DVU1641 156, 289
DVU1642 hypothetical protein DVU1642 156, 289
DVU1730 DNA-binding protein 90, 289
DVU1735 hypothetical protein DVU1735 41, 102
DVU1757 phage integrase family site specific recombinase 21, 102
DVU1815 cytochrome c oxidase subunit I 102, 155
DVU1821 hypothetical protein DVU1821 13, 289
DVU1822 glutamate synthase, amidotransferase subunit 13, 289
DVU1823 glutamate synthase, iron-sulfur cluster-binding subunit 13, 289
DVU2062 ATP-dependent DNA helicase UvrD 203, 289
DVU2072 cheA-3 chemotaxis protein CheA 102, 289
DVU2073 cheY-2 chemotaxis protein CheY 179, 289
DVU2074 chemotaxis protein CheW 100, 289
DVU2077 hypothetical protein DVU2077 77, 102
DVU2084 oligopeptide-binding protein 102, 217
DVU2094 thiG thiazole synthase 102, 217
DVU2190 transcriptional regulator 100, 289
DVU2423 transcriptional regulator 90, 289
DVU2599 hypothetical protein DVU2599 102, 210
DVU2694 hypothetical protein DVU2694 137, 289
DVU2742 livM high-affinity branched chain amino acid ABC transporter permease 156, 289
DVU2744 high-affinity branched-chain amino acid ABC transporter perisplasmic amino acid binding protein 156, 289
DVU2781 hypothetical protein DVU2781 102, 205
DVU3152 sensory box histidine kinase 19, 102
DVU3244 hypothetical protein DVU3244 247, 289
DVU3289 hypothetical protein DVU3289 106, 289
DVUA0082 phage integrase family site specific recombinase 44, 289
DVUA0083 hypothetical protein DVUA0083 61, 289
DVUA0084 AbrB family transcriptional regulator 156, 289
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for DVU2072
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend