Organism : Desulfovibrio vulgaris Hildenborough
| Module List :
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DVU2517
hypothetical protein DVU2517
Functional Annotations (2)
Function | System |
---|---|
5'-nucleotidase activity | go/ molecular_function |
IMP-GMP specific 5'-nucleotidase activity | go/ molecular_function |
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Regulation information for DVU2517
(Mouseover regulator name to see its description)
Regulator | Module | Operator |
---|---|---|
DVU0230 | 234 | tf |
DVU0525 | 234 | tf |
DVU1584 DVU2251 |
234 | combiner |
DVU2036 DVU2532 |
234 | combiner |
DVU2423 | 234 | tf |
DVU2527 DVU0653 |
234 | combiner |
DVU2644 DVU0653 |
234 | combiner |
DVU2644 DVU2582 |
234 | combiner |
DVU3080 DVU0653 |
234 | combiner |
DVUA0057 | 234 | tf |
DVUA0151 | 234 | tf |
DVU0525 | 203 | tf |
DVU0653 | 203 | tf |
DVU0804 DVU0230 |
203 | combiner |
DVU1063 | 203 | tf |
DVU1083 DVU2832 |
203 | combiner |
DVU1754 | 203 | tf |
DVU2036 | 203 | tf |
DVU2036 DVU2097 |
203 | combiner |
DVU2423 | 203 | tf |
DVU2423 DVU2832 |
203 | combiner |
DVU2588 DVU0621 |
203 | combiner |
DVU2588 DVU1083 |
203 | combiner |
DVU2836 DVU0653 |
203 | combiner |
DVUA0024 | 203 | tf |
DVUA0143 | 203 | tf |
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Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
Click on the RegPredict links to explore the motif in RegPredict.
Motif Id | e-value | Consensus | Motif Logo | RegPredict |
---|---|---|---|---|
389 | 1.10e+03 | CGccGtaTGCC |
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RegPredict |
390 | 4.10e+03 | AcgcatCcgttaaC.TtA |
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RegPredict |
447 | 4.80e-01 | ATatTCtaTgTCcAAaagCatT |
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RegPredict |
448 | 3.10e+01 | aGgtATatActaaAAtaGtat |
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RegPredict |
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Functional Enrichment for DVU2517
Function | System |
---|---|
5'-nucleotidase activity | go/ molecular_function |
IMP-GMP specific 5'-nucleotidase activity | go/ molecular_function |
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Module neighborhood information for DVU2517
Gene | Common Name | Description | Module membership |
---|---|---|---|
DVU0070 | Ser/Thr protein phosphatase family protein | 7, 234 | |
DVU0351 | cytidine 5'monophosphate N-acetylneuraminic acid synthetase /polysaccharide biosynthesis protein | 234, 341 | |
DVU1035 | glucokinase | 234, 341 | |
DVU1239 | hypothetical protein DVU1239 | 234, 341 | |
DVU1385 | hypothetical protein DVU1385 | 202, 203 | |
DVU1431 | hpt domain-containing protein/STAS domain-containing protein | 202, 203 | |
DVU1508 | hypothetical protein DVU1508 | 234, 341 | |
DVU1836 | tRNA nucleotidyltransferase | 202, 203 | |
DVU1858 | cold shock domain-containing protein | 234, 341 | |
DVU2062 | ATP-dependent DNA helicase UvrD | 203, 289 | |
DVU2218 | GTP-binding protein | 203, 264 | |
DVU2283 | hypothetical protein DVU2283 | 234, 341 | |
DVU2295 | methyl-accepting chemotaxis protein | 202, 203 | |
DVU2336 | carboxyl-terminal protease | 234, 341 | |
DVU2424 | hypothetical protein DVU2424 | 203, 345 | |
DVU2456 | hypothetical protein DVU2456 | 134, 234 | |
DVU2517 | hypothetical protein DVU2517 | 203, 234 | |
DVU2628 | hypothetical protein | 234, 326 | |
DVU2755 | hypothetical protein DVU2755 | 27, 234 | |
DVU2874 | hypothetical protein DVU2874 | 234, 341 | |
DVU2906 | umuC | umuC protein | 15, 203 |
DVU3110 | oxidoreductase | 234, 341 | |
DVU3132 | glycerol-3-phosphate dehydrogenase, FAD-dependent | 31, 203 | |
DVU3142 | sigma-54 dependent transcriptional regulator | 197, 203 | |
DVU3211 | hypothetical protein DVU3211 | 7, 234 | |
DVU3325 | hypothetical protein DVU3325 | 234, 341 | |
DVUA0043 | polysaccharide deacetylase family protein | 234, 335 | |
DVUA0055 | hypothetical protein DVUA0055 | 200, 234 | |
DVUA0096 | major facilitator superfamily protein | 234, 341 | |
DVUA0139 | outer membrane autotransporter | 234, 340 | |
DVUA0140 | hypothetical protein DVUA0140 | 234, 340 |
Gene Page Help
Network Tab
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.
Regulation Tab
Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.
You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".
For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.
Motifs Tab
Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Functions Tab
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.
Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
Help Tab
This help page. More general help can be accessed by clicking help menu in the main navigation bar.
CircVis
Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;![](/static/images/help_images/circvis-help.png)
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
- 2. Source gene
- 3. Target genes (other module members)
- 4. Interactions between source and target genes for a particular module
- 5. Module(s) that source gene and target genes belong to
- 6. Visualisation legend
Social Tab
Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.
Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.
In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.