Organism : Desulfovibrio vulgaris Hildenborough | Module List :
DVU2885

iron-containing alcohol dehydrogenase

CircVis
Functional Annotations (14)
Function System
Alcohol dehydrogenase, class IV cog/ cog
alcohol dehydrogenase activity, metal ion-independent go/ molecular_function
alcohol dehydrogenase activity, zinc-dependent go/ molecular_function
alcohol dehydrogenase activity, iron-dependent go/ molecular_function
metabolic process go/ biological_process
metal ion binding go/ molecular_function
Glycolysis / Gluconeogenesis kegg/ kegg pathway
Fatty acid metabolism kegg/ kegg pathway
Tyrosine metabolism kegg/ kegg pathway
Chloroalkane and chloroalkene degradation kegg/ kegg pathway
Naphthalene degradation kegg/ kegg pathway
Metabolic pathways kegg/ kegg pathway
Biosynthesis of secondary metabolites kegg/ kegg pathway
Microbial metabolism in diverse environments kegg/ kegg pathway
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for DVU2885
(Mouseover regulator name to see its description)

DVU2885 is regulated by 21 influences and regulates 0 modules.
Regulators for DVU2885 (21)
Regulator Module Operator
DVU0653 334 tf
DVU1063 334 tf
DVU1517 334 tf
DVU1518 334 tf
DVU1744 334 tf
DVU2114
DVU1744
334 combiner
DVU2633
DVU1744
334 combiner
DVU2785
DVU0230
334 combiner
DVU2832
DVU1745
334 combiner
DVU2953 334 tf
DVU3142
DVU0529
334 combiner
DVU0277 87 tf
DVU0436 87 tf
DVU0436
DVU0529
87 combiner
DVU0529
DVU1083
87 combiner
DVU0653 87 tf
DVU1517 87 tf
DVU2195
DVU0529
87 combiner
DVU2785
DVU0230
87 combiner
DVUA0024 87 tf
DVUA0057 87 tf

Warning: DVU2885 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.
Click on the RegPredict links to explore the motif in RegPredict.

Motif Table (4)
Motif Id e-value Consensus Motif Logo RegPredict
171 1.70e-04 GggcttC.GCaaCg
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RegPredict
172 7.10e+02 ttTcgctGTGcTgCGgtGcgCt
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RegPredict
633 9.50e-04 tTcTtAaaGaCTTcaCATCgcTG
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RegPredict
634 2.80e+00 acCCcGcCTtG.CGc.CGtcAGC
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RegPredict
Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for DVU2885

DVU2885 is enriched for 14 functions in 3 categories.
Enrichment Table (14)
Function System
Alcohol dehydrogenase, class IV cog/ cog
alcohol dehydrogenase activity, metal ion-independent go/ molecular_function
alcohol dehydrogenase activity, zinc-dependent go/ molecular_function
alcohol dehydrogenase activity, iron-dependent go/ molecular_function
metabolic process go/ biological_process
metal ion binding go/ molecular_function
Glycolysis / Gluconeogenesis kegg/ kegg pathway
Fatty acid metabolism kegg/ kegg pathway
Tyrosine metabolism kegg/ kegg pathway
Chloroalkane and chloroalkene degradation kegg/ kegg pathway
Naphthalene degradation kegg/ kegg pathway
Metabolic pathways kegg/ kegg pathway
Biosynthesis of secondary metabolites kegg/ kegg pathway
Microbial metabolism in diverse environments kegg/ kegg pathway
Module neighborhood information for DVU2885

DVU2885 has total of 65 gene neighbors in modules 87, 334
Gene neighbors (65)
Gene Common Name Description Module membership
DVU0077 hypothetical protein DVU0077 87, 162
DVU0103 cation ABC transporter ATP-binding protein 247, 334
DVU0124 hypothetical protein DVU0124 206, 334
DVU0154 hypothetical protein DVU0154 162, 334
DVU0194 terminase large subunit 162, 334
DVU0258 sensory box histidine kinase/response regulator 83, 87
DVU0295 amine oxidase, flavin-containing 87, 162
DVU0297 hypothetical protein DVU0297 214, 334
DVU0362 hypothetical protein DVU0362 174, 334
DVU0363 pabB para-aminobenzoate synthase, component I 181, 334
DVU0446 sodium/solute symporter family protein 247, 334
DVU0651 hypothetical protein DVU0651 9, 334
DVU0661 dihydrouridine synthase family protein 87, 185
DVU0731 hypothetical protein DVU0731 87, 126
DVU0740 hypothetical protein DVU0740 87, 162
DVU0742 hypothetical protein DVU0742 83, 87
DVU0743 sensory box histidine kinase 14, 87
DVU1036 hypothetical protein DVU1036 69, 334
DVU1081 iron-sulfur cluster-binding protein 126, 334
DVU1150 hypothetical protein DVU1150 33, 334
DVU1187 hypothetical protein DVU1187 87, 176
DVU1357 hypothetical protein DVU1357 75, 87
DVU1371 HAD family hydrolase 87, 126
DVU1391 hypothetical protein DVU1391 69, 87
DVU1435 hypothetical protein DVU1435 69, 87
DVU1439 hypothetical protein DVU1439 87, 155
DVU1459 hypothetical protein DVU1459 9, 334
DVU1460 hypothetical protein DVU1460 145, 334
DVU1461 hemA glutamyl-tRNA reductase 117, 334
DVU1463 siroheme synthase 117, 334
DVU1465 CgeB family protein 87, 334
DVU1869 methyl-accepting chemotaxis protein 87, 122
DVU1903 mfd transcription-repair coupling factor 176, 334
DVU2276 hypothetical protein DVU2276 69, 334
DVU2279 hypothetical protein DVU2279 94, 334
DVU2280 amino acid permease family protein 94, 334
DVU2843 DNA mismatch endonuclease Vsr 214, 334
DVU2844 hypothetical protein DVU2844 214, 334
DVU2885 iron-containing alcohol dehydrogenase 87, 334
DVU2888 cobalt ABC transporter ATP-binding protein 316, 334
DVU2908 hypothetical protein DVU2908 69, 334
DVU2949 hypothetical protein DVU2949 33, 334
DVU2954 GGDEF domain-containing protein 69, 334
DVU2955 hypothetical protein DVU2955 69, 334
DVU2993 glycosyl transferase group 1/2 family protein 83, 87
DVU2996 NAD-dependent epimerase/dehydratase family protein 87, 150
DVU2997 hypothetical protein DVU2997 87, 150
DVU2998 hypothetical protein DVU2998 87, 150
DVU3008 NeuB family protein 87, 176
DVU3015 hypothetical protein DVU3015 83, 87
DVU3017 hypothetical protein DVU3017 69, 87
DVU3043 hypothetical protein DVU3043 181, 334
DVU3072 ABC transporter permease 126, 334
DVU3096 hypothetical protein DVU3096 17, 334
DVU3115 hypothetical protein DVU3115 33, 334
DVU3126 None 87, 150
DVU3180 GGDEF domain-containing protein 33, 87
DVU3196 twin-arginine translocation pathway signal sequence domain-containing protein 87, 214
DVU3215 response regulator 87, 250
DVU3224 sfsA sugar fermentation stimulation protein 83, 87
DVU3233 flhB flagellar biosynthesis protein FlhB 81, 334
DVU3297 tryptophan-specific transport protein 9, 334
DVU3320 hypothetical protein DVU3320 83, 334
DVU3343 hypothetical protein DVU3343 330, 334
DVUA0103 invX HrpO family type III secretion protein 131, 334
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for DVU2885
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend