Organism : Desulfovibrio vulgaris Hildenborough | Module List :
DVU3047
class IV aminotransferase
Functional Annotations (8)
Function | System |
---|---|
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase | cog/ cog |
branched-chain-amino-acid transaminase activity | go/ molecular_function |
metabolic process | go/ biological_process |
Valine leucine and isoleucine degradation | kegg/ kegg pathway |
Valine leucine and isoleucine biosynthesis | kegg/ kegg pathway |
Pantothenate and CoA biosynthesis | kegg/ kegg pathway |
Metabolic pathways | kegg/ kegg pathway |
Biosynthesis of secondary metabolites | kegg/ kegg pathway |
Regulation information for DVU3047
(Mouseover regulator name to see its description)
Regulator | Module | Operator |
---|---|---|
DVU0682 | 175 | tf |
DVU0682 DVU1788 |
175 | combiner |
DVU0682 DVU2953 |
175 | combiner |
DVU0936 DVU0118 |
175 | combiner |
DVU1419 | 175 | tf |
DVU2111 DVU0946 |
175 | combiner |
DVU2111 DVU1949 |
175 | combiner |
DVU2557 | 175 | tf |
DVU2588 DVU0118 |
175 | combiner |
DVU2956 DVU2319 |
175 | combiner |
DVU0110 | 35 | tf |
DVU0309 | 35 | tf |
DVU0653 | 35 | tf |
DVU0749 DVU0110 |
35 | combiner |
DVU1518 DVU1561 |
35 | combiner |
DVU2423 | 35 | tf |
DVU2547 | 35 | tf |
DVU2547 DVU0110 |
35 | combiner |
DVU2960 DVU0110 |
35 | combiner |
DVU3066 | 35 | tf |
DVU3167 | 35 | tf |
DVU3167 DVU1340 |
35 | combiner |
Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
Click on the RegPredict links to explore the motif in RegPredict.
Motif Id | e-value | Consensus | Motif Logo | RegPredict |
---|---|---|---|---|
69 | 2.10e+04 | aggAAacCGaaACgggAcaT | RegPredict | |
70 | 4.00e+03 | ctCCccGcc.GgC..caaccc | RegPredict | |
335 | 1.30e+02 | tttacTCCtTG | RegPredict | |
336 | 7.80e+04 | aA...GtCatgaaAcaCtttt.Ca | RegPredict |
Functional Enrichment for DVU3047
Function | System |
---|---|
Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase | cog/ cog |
branched-chain-amino-acid transaminase activity | go/ molecular_function |
metabolic process | go/ biological_process |
Valine leucine and isoleucine degradation | kegg/ kegg pathway |
Valine leucine and isoleucine biosynthesis | kegg/ kegg pathway |
Pantothenate and CoA biosynthesis | kegg/ kegg pathway |
Metabolic pathways | kegg/ kegg pathway |
Biosynthesis of secondary metabolites | kegg/ kegg pathway |
Module neighborhood information for DVU3047
Gene | Common Name | Description | Module membership |
---|---|---|---|
DVU0007 | asnC | asparaginyl-tRNA synthetase | 35, 117 |
DVU0137 | hypothetical protein DVU0137 | 109, 175 | |
DVU0247 | response regulator | 35, 62 | |
DVU0291 | ABC transporter ATP-binding protein | 35, 162 | |
DVU0493 | hypothetical protein DVU0493 | 139, 175 | |
DVU0571 | ald | alanine dehydrogenase | 150, 175 |
DVU0760 | hypothetical protein DVU0760 | 35, 117 | |
DVU0761 | lipoprotein | 35, 236 | |
DVU0815 | AsmA family protein | 35, 277 | |
DVU0902 | hypothetical protein | 175, 331 | |
DVU0983 | hypothetical protein DVU0983 | 35, 141 | |
DVU1032 | hypothetical protein DVU1032 | 175, 208 | |
DVU1159 | hypothetical protein DVU1159 | 161, 175 | |
DVU1218 | hypothetical protein DVU1218 | 175, 271 | |
DVU1219 | hypothetical protein DVU1219 | 35, 112 | |
DVU1222 | hypothetical protein DVU1222 | 175, 224 | |
DVU1241 | hypothetical protein DVU1241 | 122, 175 | |
DVU1368 | rhodanese-like domain-containing protein | 35, 236 | |
DVU1475 | PhoU family protein | 155, 175 | |
DVU1534 | hypothetical protein DVU1534 | 31, 175 | |
DVU1547 | sensory box protein | 35, 112 | |
DVU1771 | hydC | [Fe] hydrogenase gamma [Desulfovibrio vulgaris str. Hildenborough] | 175, 198 |
DVU1817 | cyf | cytochrome c-553 | 132, 175 |
DVU1853 | hypothetical protein DVU1853 | 105, 175 | |
DVU1991 | hypothetical protein DVU1991 | 175, 321 | |
DVU1999 | sulfate transporter family protein | 175, 291 | |
DVU2005 | hypothetical protein DVU2005 | 175, 201 | |
DVU2019 | hypothetical protein DVU2019 | 175, 198 | |
DVU2020 | hypothetical protein DVU2020 | 77, 175 | |
DVU2233 | hypothetical protein DVU2233 | 35, 185 | |
DVU2329 | hypB | hydrogenase accessory protein HypB | 35, 117 |
DVU2330 | MRP family protein | 35, 141 | |
DVU2431 | hypothetical protein DVU2431 | 175, 296 | |
DVU2490 | histidinol phosphatase | 35, 236 | |
DVU2491 | ABC transporter ATP-binding protein | 35, 117 | |
DVU2545 | iron-containing alcohol dehydrogenase | 35, 277 | |
DVU2546 | sensory box histidine kinase | 35, 277 | |
DVU2618 | hypothetical protein DVU2618 | 35, 181 | |
DVU2636 | hypothetical protein DVU2636 | 35, 271 | |
DVU2670 | hypothetical protein DVU2670 | 27, 175 | |
DVU2763 | TPR/GGDEF domain-containing protein | 175, 198 | |
DVU2765 | metallo-beta-lactamase family protein | 35, 117 | |
DVU2766 | hypothetical protein DVU2766 | 35, 117 | |
DVU2767 | iron-sulfur flavoprotein | 35, 117 | |
DVU2776 | dsvC | dissimilatory sulfite reductase subunit gamma | 175, 307 |
DVU2813 | hypothetical protein DVU2813 | 175, 198 | |
DVU2953 | GntR family transcriptional regulator | 35, 69 | |
DVU2973 | integration host factor subunit beta | 132, 175 | |
DVU3047 | class IV aminotransferase | 35, 175 | |
DVU3048 | asd | aspartate-semialdehyde dehydrogenase | 35, 172 |
DVU3049 | hemerythrin family protein | 35, 229 | |
DVU3067 | hypF | [NiFe] hydrogenase maturation protein HypF [Desulfovibrio vulgaris str. Hildenborough] | 35, 117 |
DVU3068 | GAF domain/sensory box/EAL domain-containing protein | 35, 62 | |
DVU3104 | peptidoglycan-associated lipoprotein | 6, 175 | |
DVU3172 | hypothetical protein DVU3172 | 35, 117 | |
DVU3213 | hypothetical protein DVU3213 | 175, 201 | |
DVU3268 | hypothetical protein DVU3268 | 105, 175 | |
DVU3364 | hypothetical protein DVU3364 | 35, 62 | |
DVUA0026 | hypothetical protein DVUA0026 | 175, 233 | |
DVUA0027 | hypothetical protein DVUA0027 | 131, 175 | |
DVUA0028 | hypothetical protein DVUA0028 | 175, 263 |
Gene Page Help
Network Tab
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
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Regulation Tab
Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.
You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".
For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.
Motifs Tab
Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Functions Tab
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.
Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
Help Tab
This help page. More general help can be accessed by clicking help menu in the main navigation bar.
CircVis
Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
- 2. Source gene
- 3. Target genes (other module members)
- 4. Interactions between source and target genes for a particular module
- 5. Module(s) that source gene and target genes belong to
- 6. Visualisation legend
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In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.