Organism : Geobacter sulfurreducens | Module List :
GSU0337 hemL

glutamate-1-semialdehyde-2,1-aminomutase (NCBI)

CircVis
Functional Annotations (10)
Function System
Glutamate-1-semialdehyde aminotransferase cog/ cog
transaminase activity go/ molecular_function
biosynthetic process go/ biological_process
pyridoxal phosphate binding go/ molecular_function
tetrapyrrole biosynthetic process go/ biological_process
glutamate-1-semialdehyde 2,1-aminomutase activity go/ molecular_function
Porphyrin and chlorophyll metabolism kegg/ kegg pathway
Metabolic pathways kegg/ kegg pathway
Biosynthesis of secondary metabolites kegg/ kegg pathway
hemL tigr/ tigrfam
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for GSU0337
(Mouseover regulator name to see its description)

GSU0337 is regulated by 26 influences and regulates 0 modules.
Regulators for GSU0337 hemL (26)
Regulator Module Operator
GSU0031 170 tf
GSU0359 170 tf
GSU0581 170 tf
GSU1522 170 tf
GSU1626 170 tf
GSU1863 170 tf
GSU1905 170 tf
GSU1934 170 tf
GSU2581 170 tf
GSU2625 170 tf
GSU2753 170 tf
GSU2831 170 tf
GSU3053 170 tf
GSU3229 170 tf
GSU3396 170 tf
GSU0581 139 tf
GSU0732 139 tf
GSU1201 139 tf
GSU1218 139 tf
GSU1419 139 tf
GSU1495 139 tf
GSU1525 139 tf
GSU1934 139 tf
GSU2523 139 tf
GSU2571 139 tf
GSU3060 139 tf

Warning: GSU0337 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
2438 3.70e-02 TaatgC.atAAaTttTcA.ctctT
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2439 4.20e+00 taaAccctTtTtTCag.cca.aAa
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2500 1.90e-02 aT.ttTcatcg.aTTatCACt.cC
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2501 2.80e+00 ACatactTa.CTgtActgtcaga
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for GSU0337

GSU0337 is enriched for 10 functions in 3 categories.
Enrichment Table (10)
Function System
Glutamate-1-semialdehyde aminotransferase cog/ cog
transaminase activity go/ molecular_function
biosynthetic process go/ biological_process
pyridoxal phosphate binding go/ molecular_function
tetrapyrrole biosynthetic process go/ biological_process
glutamate-1-semialdehyde 2,1-aminomutase activity go/ molecular_function
Porphyrin and chlorophyll metabolism kegg/ kegg pathway
Metabolic pathways kegg/ kegg pathway
Biosynthesis of secondary metabolites kegg/ kegg pathway
hemL tigr/ tigrfam
Module neighborhood information for GSU0337

GSU0337 has total of 31 gene neighbors in modules 139, 170
Gene neighbors (31)
Gene Common Name Description Module membership
GSU0095 GSU0095 conserved hypothetical protein TIGR00103 (VIMSS) 83, 170
GSU0114 atpC ATP synthase F1, epsilon subunit (NCBI) 170, 230
GSU0333 atpE ATP synthase F0, C subunit (NCBI) 116, 170
GSU0335 GSU0335 hypothetical protein (VIMSS) 35, 170
GSU0336 GSU0336 hypothetical protein (VIMSS) 62, 170
GSU0337 hemL glutamate-1-semialdehyde-2,1-aminomutase (NCBI) 139, 170
GSU0883 GSU0883 ferric enterobactin receptor, putative (VIMSS) 139, 192
GSU1104 GSU1104 hypothetical protein (VIMSS) 139, 168
GSU1105 pepQ-1 xaa-pro dipeptidase (NCBI) 139, 168
GSU1111 GSU1111 conserved hypothetical protein TIGR00048 (VIMSS) 139, 212
GSU1278 GSU1278 conserved hypothetical protein (VIMSS) 170, 248
GSU1312 GSU1312 radical SAM domain protein, selenocysteine-containing (NCBI) 139, 230
GSU1323 GSU1323 conserved hypothetical protein (NCBI) 98, 139
GSU1357 GSU1357 conserved hypothetical protein (VIMSS) 139, 324
GSU1440 GSU1440 hypothetical protein (VIMSS) 67, 139
GSU1451 GSU1451 3-hydroxyisobutyrate dehydrogenase family protein (VIMSS) 170, 243
GSU1578 mutA B12-binding protein (NCBI) 139, 219
GSU1637 pyrE orotate phosphoribosyltransferase (NCBI) 170, 215
GSU1754 kamA L-lysine 2,3-aminomutase (NCBI) 74, 139
GSU1759 purN phosphoribosylglycinamide formyltransferase (VIMSS) 98, 139
GSU1771 GSU1771 conserved domain protein (NCBI) 17, 170
GSU1792 clpP ATP-dependent Clp protease, proteolytic subunit ClpP (VIMSS) 161, 170
GSU1793 tig trigger factor (NCBI) 161, 170
GSU1860 GSU1860 keto/oxoacid ferredoxin oxidoreductase, alpha subunit (VIMSS) 170, 239
GSU1861 GSU1861 keto/oxoacid ferredoxin oxidoreductase, beta subunit (VIMSS) 170, 199
GSU1863 GSU1863 transcriptional regulator, Ros/MucR family (VIMSS) 170, 215
GSU1882 ptsH phosphocarrier protein HPr (NCBI) 168, 170
GSU1892 GSU1892 phosphatase, YrbI family (NCBI) 98, 139
GSU2025 aroB 3-dehydroquinate synthase (NCBI) 98, 139
GSU2027 aroC chorismate synthase (NCBI) 139, 219
GSU2245 GSU2245 UDP-N-acetylglucosamine 2-epimerase (VIMSS) 170, 316
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for GSU0337
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend