Organism : Methanococcus maripaludis S2 | Module List :
MMP1064

adenylate cyclase

CircVis
Functional Annotations (5)
Function System
Adenylate cyclase, class 2 (thermophilic) cog/ cog
cAMP biosynthetic process go/ biological_process
calcium- and calmodulin-responsive adenylate cyclase activity go/ molecular_function
Purine metabolism kegg/ kegg pathway
cyaB tigr/ tigrfam
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for MMP1064
(Mouseover regulator name to see its description)

MMP1064 is regulated by 5 influences and regulates 0 modules.
Regulators for MMP1064 (5)
Regulator Module Operator
MMP0036
MMP0840
51 combiner
MMP0052
MMP0257
51 combiner
MMP0097 51 tf
MMP1015 51 tf
MMP1347
Formate
51 combiner

Warning: MMP1064 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
669 2.30e-02 GtGtgCtcccaac
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670 1.10e+04 GGGggAACc
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763 7.30e+03 CTGCTaCTGAGG
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764 2.80e+04 GcACCTGTtG
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for MMP1064

MMP1064 is enriched for 5 functions in 3 categories.
Enrichment Table (5)
Function System
Adenylate cyclase, class 2 (thermophilic) cog/ cog
cAMP biosynthetic process go/ biological_process
calcium- and calmodulin-responsive adenylate cyclase activity go/ molecular_function
Purine metabolism kegg/ kegg pathway
cyaB tigr/ tigrfam
Module neighborhood information for MMP1064

MMP1064 has total of 63 gene neighbors in modules 4, 51
Gene neighbors (63)
Gene Common Name Description Module membership
MMP0011 DNA-cytosine methyltransferase 4, 104
MMP0046 hypothetical protein MMP0046 20, 51, 140
MMP0074 hypothetical protein MMP0074 51, 140
MMP0091 hypothetical protein MMP0091 51, 106
MMP0105 hypothetical protein MMP0105 4, 107
MMP0116 argC N-acetyl-gamma-glutamyl-phosphate reductase 8, 51
MMP0140 (NiFe) hydrogenase maturation protein HypF 4, 85
MMP0141 hypothetical protein MMP0141 41, 51
MMP0142 thiamine pyrophosphate dependent protein 17, 41, 51
MMP0181 hypothetical protein MMP0181 4, 58
MMP0216 cation transport ATPase 4, 41, 95
MMP0243 hypothetical protein MMP0243 4, 25, 38
MMP0268 truA tRNA pseudouridine synthase A 49, 51
MMP0286 hypothetical protein MMP0286 29, 51
MMP0296 hypothetical protein MMP0296 4, 129
MMP0333 hypothetical protein MMP0333 4, 126
MMP0392 purD phosphoribosylamine--glycine ligase 4, 75, 104
MMP0401 metE methionine synthase 4, 15, 80
MMP0412 MiaB-like tRNA modifying protein 4, 25, 87
MMP0440 DNA-directed RNA polymerase subunit E' 51, 61
MMP0441 rpoE2 DNA-directed RNA polymerase subunit E 51, 61
MMP0442 hypothetical protein MMP0442 3, 51, 61
MMP0443 rps24e 30S ribosomal protein S24e 3, 51, 96, 97
MMP0444 30S ribosomal protein S27ae 3, 51, 97
MMP0447 nitrogenase-like protein 4, 146
MMP0448 hypothetical protein MMP0448 4, 70
MMP0479 hypothetical protein MMP0479 4, 95
MMP0503 hypothetical protein MMP0503 4, 126
MMP0524 hypothetical protein MMP0524 4, 58, 146, 153, 163
MMP0525 hypothetical protein MMP0525 4, 146, 163
MMP0571 moaA molybdenum cofactor biosynthesis protein A 4, 89
MMP0670 hypothetical protein MMP0670 41, 51
MMP0671 ywbE hypothetical protein MMP0671 51, 87
MMP0694 beta-lactamase-like protein 51, 109, 149
MMP0695 psmB proteasome subunit beta 51, 92
MMP0884 hypothetical protein MMP0884 39, 51
MMP0886 cobalt ABC transporter inner membrane protein 4, 151
MMP0901 ATP/GTP-binding motif-containing protein 20, 51
MMP0948 hypothetical protein MMP0948 4, 115
MMP0949 tRNA CCA-pyrophosphorylase 4, 70
MMP1000 hypothetical protein MMP1000 4, 95
MMP1064 adenylate cyclase 4, 51
MMP1130 hypothetical protein MMP1130 4, 38
MMP1150 mtaA uroporphyrinogen decarboxylase 4, 41, 95
MMP1228 hypothetical protein MMP1228 4, 22, 142
MMP1303 sensory transduction histidine kinase 4, 28, 66
MMP1304 response regulator receiver protein 4, 126
MMP1305 hypothetical protein MMP1305 4, 126
MMP1307 methyltransferase-like protein 4, 149
MMP1380 chlorohydrolase 51, 92
MMP1381 beta-lactamase-like protein 51, 92
MMP1399 aspartate/glutamate/uridylate kinase 51, 61
MMP1431 2pgk 2-phosphoglycerate kinase 49, 51
MMP1432 purA adenylosuccinate synthetase 29, 51, 130
MMP1444 methionine aminopeptidase 20, 51, 61, 92
MMP1590 ExsB family protein 24, 51
MMP1594 hypothetical protein MMP1594 51, 143
MMP1645 aspartate/glutamate/uridylate kinase 4, 126
MMP1698 hypothetical protein MMP1698 4, 8
RNA_17 tRNA-Pro2 Pro tRNA 4, 100
Unanno_23 None 4, 101
Unanno_27 None 4, 101
Unanno_51 None 4, 126
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for MMP1064
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend