Organism : Pseudomonas aeruginosa | Module List :
PA3589

acetyl-CoA acetyltransferase (NCBI)

CircVis
Functional Annotations (19)
Function System
Acetyl-CoA acetyltransferase cog/ cog
acetyl-CoA C-acetyltransferase activity go/ molecular_function
Fatty acid metabolism kegg/ kegg pathway
Synthesis and degradation of ketone bodies kegg/ kegg pathway
Valine leucine and isoleucine degradation kegg/ kegg pathway
Lysine degradation kegg/ kegg pathway
Benzoate degradation kegg/ kegg pathway
Tryptophan metabolism kegg/ kegg pathway
Pyruvate metabolism kegg/ kegg pathway
Glyoxylate and dicarboxylate metabolism kegg/ kegg pathway
Propanoate metabolism kegg/ kegg pathway
Butanoate metabolism kegg/ kegg pathway
Carbon fixation pathways in prokaryotes kegg/ kegg pathway
Terpenoid backbone biosynthesis kegg/ kegg pathway
Metabolic pathways kegg/ kegg pathway
Biosynthesis of secondary metabolites kegg/ kegg pathway
Microbial metabolism in diverse environments kegg/ kegg pathway
Two-component system kegg/ kegg pathway
AcCoA-C-Actrans tigr/ tigrfam
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for PA3589
(Mouseover regulator name to see its description)

PA3589 is regulated by 48 influences and regulates 0 modules.
Regulators for PA3589 (48)
Regulator Module Operator
PA0056 36 tf
PA0191 36 tf
PA0306 36 tf
PA0393 36 tf
PA0512 36 tf
PA0701 36 tf
PA0748 36 tf
PA0784 36 tf
PA0893 36 tf
PA1285 36 tf
PA1347 36 tf
PA1351 36 tf
PA1949 36 tf
PA1980 36 tf
PA2276 36 tf
PA2547 36 tf
PA3045 36 tf
PA3249 36 tf
PA3381 36 tf
PA3420 36 tf
PA3596 36 tf
PA3711 36 tf
PA3771 36 tf
PA3932 36 tf
PA4074 36 tf
PA4341 36 tf
PA5032 36 tf
PA5293 36 tf
PA5382 36 tf
PA5562 36 tf
PA0056 463 tf
PA0133 463 tf
PA0306 463 tf
PA0701 463 tf
PA0828 463 tf
PA1109 463 tf
PA1351 463 tf
PA1399 463 tf
PA1826 463 tf
PA2050 463 tf
PA2376 463 tf
PA3002 463 tf
PA3045 463 tf
PA3381 463 tf
PA3594 463 tf
PA3714 463 tf
PA3771 463 tf
PA5032 463 tf

Warning: PA3589 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
2904 8.20e-02 aAcaAcaAC.aat..AAgaat
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2905 6.50e+03 AcaTCatcaA.cAgt
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3742 5.00e-09 atAAGaAAaACA
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3743 2.20e-08 CgcGGcGaatcCttCGAaAA.C
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for PA3589

PA3589 is enriched for 19 functions in 3 categories.
Enrichment Table (19)
Function System
Acetyl-CoA acetyltransferase cog/ cog
acetyl-CoA C-acetyltransferase activity go/ molecular_function
Fatty acid metabolism kegg/ kegg pathway
Synthesis and degradation of ketone bodies kegg/ kegg pathway
Valine leucine and isoleucine degradation kegg/ kegg pathway
Lysine degradation kegg/ kegg pathway
Benzoate degradation kegg/ kegg pathway
Tryptophan metabolism kegg/ kegg pathway
Pyruvate metabolism kegg/ kegg pathway
Glyoxylate and dicarboxylate metabolism kegg/ kegg pathway
Propanoate metabolism kegg/ kegg pathway
Butanoate metabolism kegg/ kegg pathway
Carbon fixation pathways in prokaryotes kegg/ kegg pathway
Terpenoid backbone biosynthesis kegg/ kegg pathway
Metabolic pathways kegg/ kegg pathway
Biosynthesis of secondary metabolites kegg/ kegg pathway
Microbial metabolism in diverse environments kegg/ kegg pathway
Two-component system kegg/ kegg pathway
AcCoA-C-Actrans tigr/ tigrfam
Module neighborhood information for PA3589

PA3589 has total of 35 gene neighbors in modules 36, 463
Gene neighbors (35)
Gene Common Name Description Module membership
PA0189 PA0189 probable porin (NCBI) 36, 201
PA0241 PA0241 probable major facilitator superfamily (MFS) transporter (NCBI) 25, 463
PA1025 PA1025 probable porin (NCBI) 36, 425
PA1146 PA1146 probable iron-containing alcohol dehydrogenase (NCBI) 359, 463
PA1267 PA1267 hypothetical protein (NCBI) 16, 36
PA1346 PA1346 hypothetical protein (NCBI) 36, 158
PA1826 PA1826 probable transcriptional regulator (NCBI) 373, 463
PA1827 PA1827 probable short-chain dehydrogenase (NCBI) 366, 463
PA2124 PA2124 probable dehydrogenase (NCBI) 12, 36
PA2129 cupA2 chaperone CupA2 (NCBI) 36, 439
PA2133 PA2133 hypothetical protein (NCBI) 36, 285
PA2217 PA2217 probable aldehyde dehydrogenase (NCBI) 36, 340
PA2924 hisQ histidine transport system permease HisQ (NCBI) 36, 285
PA3219 PA3219 hypothetical protein (NCBI) 211, 463
PA3395 nosY NosY protein (NCBI) 36, 497
PA3589 PA3589 acetyl-CoA acetyltransferase (NCBI) 36, 463
PA3590 PA3590 probable hydroxyacyl-CoA dehydrogenase (NCBI) 333, 463
PA3591 PA3591 probable enoyl-CoA hydratase/isomerase (NCBI) 36, 463
PA3592 PA3592 hypothetical protein (NCBI) 394, 463
PA3593 PA3593 probable acyl-CoA dehydrogenase (NCBI) 359, 463
PA3594 PA3594 probable transcriptional regulator (NCBI) 355, 463
PA4071 PA4071 hypothetical protein (NCBI) 36, 285
PA4072 PA4072 probable amino acid permease (NCBI) 36, 285
PA4083 cupB4 chaperone CupB4 (NCBI) 36, 439
PA4084 cupB3 usher CupB3 (NCBI) 12, 36
PA4088 PA4088 probable aminotransferase (NCBI) 36, 285
PA4089 PA4089 probable short-chain dehydrogenase (NCBI) 36, 285
PA4137 PA4137 probable porin (NCBI) 36, 177
PA4364 PA4364 hypothetical protein (NCBI) 463, 534
PA4365 PA4365 probable transporter (NCBI) 109, 463
PA4818 PA4818 hypothetical protein (NCBI) 180, 463
PA4819 PA4819 probable glycosyl transferase (NCBI) 180, 463
PA4820 PA4820 hypothetical protein (NCBI) 311, 463
PA4821 PA4821 probable transporter (NCBI) 335, 463
PA5385 PA5385 hypothetical protein (NCBI) 177, 463
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for PA3589
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend