Organism : Bacillus cereus ATCC14579 | Module List :
BC0022

Pyrazinamidase (NCBI ptt file)

CircVis
Functional Annotations (3)
Function System
Amidases related to nicotinamidase cog/ cog
catalytic activity go/ molecular_function
metabolic process go/ biological_process
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BC0022
(Mouseover regulator name to see its description)

BC0022 is regulated by 23 influences and regulates 0 modules.
Regulators for BC0022 (23)
Regulator Module Operator
BC0882 9 tf
BC0954 9 tf
BC1622 9 tf
BC2379 9 tf
BC2470 9 tf
BC2526 9 tf
BC2558 9 tf
BC2904 9 tf
BC3434 9 tf
BC3449 9 tf
BC3961 9 tf
BC4650 9 tf
BC0518 256 tf
BC1531 256 tf
BC1673 256 tf
BC2401 256 tf
BC2672 256 tf
BC2979 256 tf
BC3982 256 tf
BC4010 256 tf
BC4256 256 tf
BC4501 256 tf
BC4650 256 tf

Warning: BC0022 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
3940 2.40e+05 GCAccTcAC
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3941 7.80e-02 AGGaGG
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4428 3.20e-08 gtataaAa.AgaGagGgaa
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4429 7.80e+03 GGGCGG
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BC0022

BC0022 is enriched for 3 functions in 3 categories.
Enrichment Table (3)
Function System
Amidases related to nicotinamidase cog/ cog
catalytic activity go/ molecular_function
metabolic process go/ biological_process
Module neighborhood information for BC0022

BC0022 has total of 59 gene neighbors in modules 9, 256
Gene neighbors (59)
Gene Common Name Description Module membership
BC0022 BC0022 Pyrazinamidase (NCBI ptt file) 9, 256
BC0212 BC0212 hypothetical protein (NCBI ptt file) 9, 128
BC0312 BC0312 UDP-glucose 4-epimerase (NCBI ptt file) 9, 263
BC0314 BC0314 Glycosyltransferase (NCBI ptt file) 9, 506
BC0460 BC0460 hypothetical protein (NCBI ptt file) 9, 364
BC0484 BC0484 hypothetical protein (NCBI ptt file) 9, 25
BC0563 BC0563 Biotin carboxyl carrier protein (NCBI ptt file) 9, 85
BC0771 BC0771 Protein erfK/srfK precursor (NCBI ptt file) 9, 85
BC0812 BC0812 PBS lyase HEAT-like repeat (NCBI ptt file) 62, 256
BC0932 BC0932 hypothetical protein (NCBI ptt file) 256, 453
BC0934 BC0934 hypothetical protein (NCBI ptt file) 9, 85
BC1020 BC1020 hypothetical Membrane Associated Protein (NCBI ptt file) 9, 150
BC1040 BC1040 hypothetical protein (NCBI ptt file) 9, 146
BC1042 BC1042 hypothetical Cytosolic Protein (NCBI ptt file) 10, 256
BC1046 BC1046 hypothetical protein (NCBI ptt file) 9, 489
BC1130 BC1130 hypothetical protein (NCBI ptt file) 9, 440
BC1217 BC1217 hypothetical protein (NCBI ptt file) 256, 479
BC1254 BC1254 hypothetical protein (NCBI ptt file) 9, 428
BC1284 BC1284 Immune inhibitor A precursor (NCBI ptt file) 256, 400
BC1455 BC1455 Multimodular transpeptidase-transglycosylase PBP 2A (NCBI ptt file) 223, 256
BC1462 BC1462 None 256, 468
BC1578 BC1578 hypothetical protein (NCBI ptt file) 243, 256
BC1579 BC1579 putative synthetase/amidase (NCBI ptt file) 67, 256
BC1580 BC1580 surface protein (NCBI ptt file) 67, 256
BC1678 BC1678 JEMB (NCBI ptt file) 9, 123
BC1704 BC1704 Transporter, Drug/Metabolite Exporter family (NCBI ptt file) 230, 256
BC1796 BC1796 hypothetical protein (NCBI ptt file) 256, 421
BC1848 BC1848 Prophage helix-turn-helix protein (NCBI ptt file) 9, 85
BC1935 BC1935 hypothetical protein (NCBI ptt file) 9, 85
BC2061 BC2061 Multidrug resistance protein B (NCBI ptt file) 256, 428
BC2115 BC2115 Transglutaminase-like enzymes, hypothetical cysteine proteases (NCBI ptt file) 9, 225
BC2379 BC2379 Transcriptional regulator (NCBI ptt file) 9, 85
BC2401 BC2401 Transcriptional regulator, MarR family (NCBI ptt file) 222, 256
BC2496 BC2496 D-alanyl-D-alanine carboxypeptidase (NCBI ptt file) 9, 139
BC2557 BC2557 Prophage helix-turn-helix protein (NCBI ptt file) 62, 256
BC2620 BC2620 Penicillin-binding protein transpeptidase (NCBI ptt file) 9, 141
BC2688 BC2688 Penicillin-binding protein (NCBI ptt file) 254, 256
BC2742 BC2742 Transcriptional regulator, GntR family (NCBI ptt file) 9, 453
BC2799 BC2799 Macrolide glycosyltransferase (NCBI ptt file) 254, 256
BC2857 BC2857 hypothetical protein (NCBI ptt file) 9, 416
BC3105 BC3105 Transcriptional regulator, AraC family (NCBI ptt file) 9, 141
BC3110 BC3110 Spore germination protein BC (NCBI ptt file) 10, 256
BC3120 BC3120 Succinoglycan biosynthesis protein (NCBI ptt file) 9, 341
BC3135 BC3135 Carboxymethylenebutenolidase-related protein (NCBI ptt file) 256, 460
BC3146 BC3146 Peptidoglycan N-acetylglucosamine deacetylase (NCBI ptt file) 9, 428
BC3227 BC3227 Two component system histidine kinase (NCBI ptt file) 55, 256
BC3301 BC3301 hypothetical Cytosolic Protein (NCBI ptt file) 9, 230
BC3428 BC3428 Lysine exporter protein (NCBI ptt file) 256, 257
BC3434 BC3434 Transcriptional regulator, DeoR family (NCBI ptt file) 9, 85
BC3514 BC3514 Glucose-1-phosphate cytidylyltransferase (NCBI ptt file) 9, 487
BC3703 BC3703 Phage protein (NCBI ptt file) 9, 141
BC3785 BC3785 3-oxoacyl-[acyl-carrier protein] reductase (NCBI ptt file) 256, 288
BC4422 BC4422 Nicotinate-nucleotide pyrophosphorylase [carboxylating] (NCBI ptt file) 9, 55
BC4439 BC4439 Ribonuclease G (NCBI ptt file) 256, 308
BC4466 BC4466 CotS-related protein (NCBI ptt file) 256, 517
BC4535 BC4535 Bacitracin transport permease protein BCRB (NCBI ptt file) 250, 256
BC4617 BC4617 hypothetical Membrane Spanning Protein (NCBI ptt file) 9, 141
BC4715 BC4715 Glucose 1-dehydrogenase (NCBI ptt file) 150, 256
BC4945 BC4945 None 9, 85
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BC0022
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend