Organism : Bacillus cereus ATCC14579 | Module List :
BC1268

hypothetical protein (NCBI ptt file)

CircVis
Functional Annotations (0)

Warning: No Functional annotations were found!

GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for BC1268
(Mouseover regulator name to see its description)

BC1268 is regulated by 22 influences and regulates 0 modules.
Regulators for BC1268 (22)
Regulator Module Operator
BC1329 17 tf
BC1363 17 tf
BC2469 17 tf
BC2517 17 tf
BC2964 17 tf
BC3588 17 tf
BC0047 184 tf
BC0230 184 tf
BC0680 184 tf
BC0993 184 tf
BC1337 184 tf
BC1695 184 tf
BC1699 184 tf
BC1987 184 tf
BC2109 184 tf
BC3072 184 tf
BC3105 184 tf
BC3175 184 tf
BC3693 184 tf
BC4081 184 tf
BC5173 184 tf
BC5368 184 tf

Warning: BC1268 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
3956 3.90e+00 atAgGaGGagAa
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3957 7.10e+02 cAGCGGg
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4284 4.60e+03 GGcGGTGc
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4285 1.30e+04 ccGCACC
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for BC1268

Warning: No Functional annotations were found!

Module neighborhood information for BC1268

BC1268 has total of 43 gene neighbors in modules 17, 184
Gene neighbors (43)
Gene Common Name Description Module membership
BC0680 BC0680 Transcriptional regulator, PBSX family (NCBI ptt file) 184, 248
BC0741 BC0741 hypothetical protein (NCBI ptt file) 17, 393
BC0869 BC0869 hypothetical protein (NCBI ptt file) 17, 463
BC0878 BC0878 IG hypothetical 16724 (NCBI ptt file) 17, 334
BC0904 BC0904 hypothetical protein (NCBI ptt file) 17, 334
BC1018 BC1018 hypothetical protein (NCBI ptt file) 184, 496
BC1117 BC1117 hypothetical protein (NCBI ptt file) 184, 496
BC1162 BC1162 hypothetical protein (NCBI ptt file) 17, 464
BC1268 BC1268 hypothetical protein (NCBI ptt file) 17, 184
BC1501 BC1501 hypothetical protein (NCBI ptt file) 17, 384
BC1702 BC1702 hypothetical protein (NCBI ptt file) 184, 497
BC1891 BC1891 Phage protein (NCBI ptt file) 17, 323
BC1961 BC1961 hypothetical Membrane Spanning Protein (NCBI ptt file) 184, 497
BC2419 BC2419 Phage protein (NCBI ptt file) 184, 464
BC2442 BC2442 Transcriptional regulator, LuxR family (NCBI ptt file) 184, 187
BC2509 BC2509 Sortase (NCBI ptt file) 17, 334
BC2559 BC2559 Phage protein (NCBI ptt file) 184, 504
BC2560 BC2560 hypothetical protein (NCBI ptt file) 138, 184
BC2561 BC2561 Phage protein (NCBI ptt file) 138, 184
BC2562 BC2562 Phage protein (NCBI ptt file) 184, 464
BC2563 BC2563 Phage replication protein (NCBI ptt file) 184, 464
BC2564 BC2564 Phage protein (NCBI ptt file) 138, 184
BC2565 BC2565 Phage protein (NCBI ptt file) 184, 464
BC2567 BC2567 Phage protein (NCBI ptt file) 184, 463
BC2739 BC2739 Fosfomycin resistance protein (NCBI ptt file) 17, 289
BC2845 BC2845 hypothetical protein (NCBI ptt file) 17, 289
BC3222 BC3222 ABC transporter ATP-binding protein (NCBI ptt file) 17, 196
BC3352 BC3352 hypothetical protein (NCBI ptt file) 184, 497
BC3360 BC3360 Methyltransferase (NCBI ptt file) 17, 334
BC3417 BC3417 hypothetical protein (NCBI ptt file) 17, 521
BC3579 BC3579 hypothetical Membrane Spanning Protein (NCBI ptt file) 17, 186
BC3712 BC3712 hypothetical Membrane Spanning Protein (NCBI ptt file) 17, 46
BC3750 BC3750 UDP-N-acetylglucosamine 4,6-dehydratase (NCBI ptt file) 17, 186
BC3905 BC3905 Sporulation sigma-E factor processing peptidase (NCBI ptt file) 17, 520
BC4120 BC4120 hypothetical protein (NCBI ptt file) 141, 184
BC4171 BC4171 hypothetical protein (NCBI ptt file) 17, 334
BC4252 BC4252 hypothetical protein (NCBI ptt file) 184, 205
BC4303 BC4303 putative stage IV sporulation protein (NCBI ptt file) 17, 518
BC4407 BC4407 Stage V sporulation protein B (NCBI ptt file) 17, 339
BC4529 BC4529 None 184, 504
BC4978 BC4978 hypothetical protein (NCBI ptt file) 184, 469
BC5173 BC5173 Transcriptional regulator, PBSX family (NCBI ptt file) 184, 504
VIMSS12791522 VIMSS12791522 None 17, 135
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for BC1268
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend