Organism : Clostridium acetobutylicum | Module List :
CAC2118

Cell division protein DivIVA (NCBI ptt file)

CircVis
Functional Annotations (6)
Function System
Cell division initiation protein cog/ cog
hydrogen-transporting two-sector ATPase activity go/ molecular_function
proton-transporting ATP synthase complex go/ cellular_component
hydrogen ion transporting ATP synthase activity, rotational mechanism go/ molecular_function
proton-transporting ATPase activity, rotational mechanism go/ molecular_function
DivI1A_domain tigr/ tigrfam
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for CAC2118
(Mouseover regulator name to see its description)

CAC2118 is regulated by 26 influences and regulates 0 modules.
Regulators for CAC2118 (26)
Regulator Module Operator
CAC0115 295 tf
CAC0162 295 tf
CAC0402 295 tf
CAC0493 295 tf
CAC0549 295 tf
CAC0627 295 tf
CAC0951 295 tf
CAC2071 295 tf
CAC2471 295 tf
CAC3472 295 tf
CAC3603 295 tf
CAC3647 295 tf
CAC0078 325 tf
CAC0162 325 tf
CAC0402 325 tf
CAC0474 325 tf
CAC0493 325 tf
CAC0977 325 tf
CAC1675 325 tf
CAC1832 325 tf
CAC2071 325 tf
CAC2634 325 tf
CAC2889 325 tf
CAC3192 325 tf
CAC3429 325 tf
CAC3603 325 tf

Warning: CAC2118 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
7242 1.20e+04 CGCaCG
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7243 4.30e-07 GGAGgta
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7302 1.20e-07 aGGAGg
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7303 2.60e+03 C.CtGcCC
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for CAC2118

CAC2118 is enriched for 6 functions in 3 categories.
Module neighborhood information for CAC2118

CAC2118 has total of 34 gene neighbors in modules 295, 325
Gene neighbors (34)
Gene Common Name Description Module membership
CAC0024 CAC0024 Membrane protein, related to Actinobacillus protein (1944168) (NCBI ptt file) 38, 295
CAC0322 CAC0322 Sensory protein, containing EAL-domain (NCBI ptt file) 232, 295
CAC0327 CAC0327 Bacterioferritin comigratory protein (AHPC/TSA family) (NCBI ptt file) 239, 325
CAC0438 CAC0438 Predicted metal-binding protein (NCBI ptt file) 182, 325
CAC0537 CAC0537 Acetylxylan esterase, acyl-CoA esterase or GDSL lipase family, strong similarity to C-terminal region of endoglucanase E precursor (NCBI ptt file) 289, 325
CAC0827 CAC0827 Fructose-bisphosphate aldolase (NCBI ptt file) 32, 295
CAC0951 CAC0951 Ferric uptake regulation protein (NCBI ptt file) 25, 295
CAC0976 CAC0976 Uncharacterized conserved protein, ortholog yuzA B.subtilis (NCBI ptt file) 268, 295
CAC1027 CAC1027 Flavoprotein (NCBI ptt file) 295, 325
CAC1313 CAC1313 Hypothetical protein (NCBI ptt file) 63, 295
CAC1733 rpmB Ribosomal protein L28 (NCBI ptt file) 260, 295
CAC1755 rpsP Ribosomal protein S16 (NCBI ptt file) 260, 325
CAC1820 CAC1820 Phosphocarrier Protein (Hpr) (NCBI ptt file) 260, 295
CAC1822 CAC1822 Fusion of predicted Zn-dependent amidase/peptidase (cell wall hydrolase/DD-carboxypeptidase family) and uncharacterized domain of ErfK family; peptodoglycan-binding domain (NCBI ptt file) 295, 325
CAC1834 CAC1834 Host factor I protein Hfq (NCBI ptt file) 295, 325
CAC2118 CAC2118 Cell division protein DivIVA (NCBI ptt file) 295, 325
CAC2119 CAC2119 Predicted integral membrane protein, YggT family (NCBI ptt file) 128, 295
CAC2136 CAC2136 Hypothetical protein (NCBI ptt file) 87, 295
CAC2385 CAC2385 Hypothetical protein (NCBI ptt file) 289, 295
CAC2387 CAC2387 Hypothetical protein (NCBI ptt file) 260, 295
CAC2452 CAC2452 Flavodoxin (NCBI ptt file) 289, 325
CAC2646 sipS Signal peptidase I (NCBI ptt file) 201, 295
CAC2681 CAC2681 Hypothetical protein (NCBI ptt file) 11, 325
CAC2708 hbd Beta-hydroxybutyryl-CoA dehydrogenase, NAD-dependent (NCBI ptt file) 260, 325
CAC3075 buk Butyrate kinase, BUK (NCBI ptt file) 260, 325
CAC3076 ptb Phosphate butyryltransferase (NCBI ptt file) 260, 325
CAC3082 CAC3082 Thioredoxin reductase (NCBI ptt file) 260, 325
CAC3083 CAC3083 Thioredoxin (NCBI ptt file) 260, 325
CAC3165 CAC3165 Hypothetical protein (NCBI ptt file) 49, 325
CAC3184 CAC3184 4-diphosphocytidyl-2-methylerithritol synthase (Sugar Nucleotide Phosphorylase family) (NCBI ptt file) 87, 295
CAC3185 CAC3185 Membrane-associated protein containing a homolog of PilT-like ATPase N-terminal domain, YACL B.subtilis ortholog (NCBI ptt file) 283, 295
CAC3206 CAC3206 Ribosomal protein S1 domain family protein (NCBI ptt file) 38, 295
CAC3211 hbs DNA binding protein HU (NCBI ptt file) 32, 295
CAC3231 CAC3231 Predicted phosphatase, HAD superfamily (NCBI ptt file) 239, 295
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for CAC2118
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend