Organism : Clostridium acetobutylicum | Module List :
CAC2918 pmi

Mannose-6 phospate isomelase (NCBI ptt file)

CircVis
Functional Annotations (4)
Function System
Phosphomannose isomerase cog/ cog
mannose-6-phosphate isomerase activity go/ molecular_function
carbohydrate metabolic process go/ biological_process
zinc ion binding go/ molecular_function
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for CAC2918
(Mouseover regulator name to see its description)

CAC2918 is regulated by 19 influences and regulates 0 modules.
Regulators for CAC2918 pmi (19)
Regulator Module Operator
CAC0078 360 tf
CAC0571 360 tf
CAC0766 360 tf
CAC1320 360 tf
CAC1451 360 tf
CAC1799 360 tf
CAC2052 360 tf
CAC2113 360 tf
CAC3199 360 tf
CAC1280 270 tf
CAC1465 270 tf
CAC1483 270 tf
CAC1867 270 tf
CAC2071 270 tf
CAC2259 270 tf
CAC2605 270 tf
CAC2955 270 tf
CAC3192 270 tf
CAC3406 270 tf

Warning: CAC2918 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
7192 5.20e+03 gaaagGaG
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7193 1.50e+04 CCAGAGG
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7370 8.90e-09 GGAGGtA
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7371 6.30e+03 GGCacGTG
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for CAC2918

CAC2918 is enriched for 4 functions in 3 categories.
Enrichment Table (4)
Function System
Phosphomannose isomerase cog/ cog
mannose-6-phosphate isomerase activity go/ molecular_function
carbohydrate metabolic process go/ biological_process
zinc ion binding go/ molecular_function
Module neighborhood information for CAC2918

CAC2918 has total of 52 gene neighbors in modules 270, 360
Gene neighbors (52)
Gene Common Name Description Module membership
CAC0132 CAC0132 Hypothetical protein (NCBI ptt file) 247, 270
CAC0423 CAC0423 Fusion: PTS system, beta-glucosides specific IIABC component (NCBI ptt file) 284, 360
CAC0425 sacA Sucrase-6-phosphate hydrolase (gene sacA) (NCBI ptt file) 92, 360
CAC0570 CAC0570 PTS enzyme II, ABC component (NCBI ptt file) 237, 360
CAC0619 CAC0619 Nitrate ABC transporter ATP binding protein (NCBI ptt file) 190, 270
CAC0644 gerKA Spore germination protein gerKA (NCBI ptt file) 324, 360
CAC0766 CAC0766 Predicted transcriptional regulator (MerR family) (NCBI ptt file) 116, 360
CAC0886 CAC0886 Hypothetical protein (NCBI ptt file) 207, 270
CAC0925 CAC0925 TPR-repeat-containing protein (NCBI ptt file) 53, 270
CAC0926 CAC0926 TPR-repeat-containing protein (NCBI ptt file) 123, 270
CAC1396 purD Phosphoribosylamine-glycine ligase (NCBI ptt file) 249, 360
CAC1442 CAC1442 Hypothetical protein (NCBI ptt file) 270, 317
CAC1446 CAC1446 Hypothetical protein (NCBI ptt file) 123, 270
CAC1595 CAC1595 Integrase/recombinase, XerC/XerD family (NCBI ptt file) 249, 360
CAC1630 CAC1630 Zn-dependent peptidase from MPP family (NCBI ptt file) 22, 360
CAC1650 CAC1650 Hypothetical protein, CF-38 family (NCBI ptt file) 123, 270
CAC1659 CAC1659 Predicted membrane protein (NCBI ptt file) 270, 282
CAC1741 CAC1741 Uncharacterized conserved protein, YLBM B.subtilis ortholog (NCBI ptt file) 151, 270
CAC1761 CAC1761 Predicted GTPase, YLQF B.subtilis ortholog (NCBI ptt file) 116, 360
CAC1763 CAC1763 Predicted endonuclease (NCBI ptt file) 166, 270
CAC1789 smbA/pyrH Uridylate kinase (NCBI ptt file) 310, 360
CAC1947 CAC1947 Phage related transcriptional regulator (Xre family) (NCBI ptt file) 270, 272
CAC2027 CAC2027 Hypothetical protein (NCBI ptt file) 270, 328
CAC2030 CAC2030 Hypothetical protein (NCBI ptt file) 270, 281
CAC2054 CAC2054 Hypothetical protein (NCBI ptt file) 270, 313
CAC2097 CAC2097 Hypothetical protein (NCBI ptt file) 270, 317
CAC2099 CAC2099 Hypothetical protein (NCBI ptt file) 270, 320
CAC2114 CAC2114 Predicted pseudouridylate synthase, YLYB B.subtilis ortholog (NCBI ptt file) 26, 270
CAC2247 CAC2247 Site-specific recombinase, DNA invertase Pin homolog (NCBI ptt file) 270, 301
CAC2259 CAC2259 Predicted transcriptional regulator of MarR-family (NCBI ptt file) 270, 351
CAC2492 CAC2492 Predicted membrane, YNAG B.subtilis ortholog (NCBI ptt file) 270, 294
CAC2512 CAC2512 Hypothetical protein (NCBI ptt file) 133, 270
CAC2609 CAC2609 Cytidine deaminase family enzyme (NCBI ptt file) 270, 320
CAC2617 CAC2617 Membrane associated methyl-chemotaxis protein, HAMP domain containing (NCBI ptt file) 66, 360
CAC2626 fabG Possible 3-ketoacyl-acyl carrier protein reductase (NCBI ptt file) 310, 360
CAC2627 CAC2627 Predicted S-adenosylmethionine-dependent methyltransferase, YtmQ B.subtilis ortholog (NCBI ptt file) 310, 360
CAC2628 CAC2628 Predicted metal-dependent peptidase (NCBI ptt file) 310, 360
CAC2650 pyrD Dihydroorotate dehydrogenase (NCBI ptt file) 116, 360
CAC2652 pyrF Orotidine-5'-phosphate decarboxylase (NCBI ptt file) 116, 360
CAC2653 pyrI Aspartate carbamoyltransferase regulatory subunit (NCBI ptt file) 116, 360
CAC2654 CAC2654 Aspartate carbamoyltransferase catalytic subunit (NCBI ptt file) 116, 360
CAC2668 CAC2668 Hypothetical protein (NCBI ptt file) 270, 317
CAC2835 gntP Gluconate permease, gntP (NCBI ptt file) 270, 288
CAC2918 pmi Mannose-6 phospate isomelase (NCBI ptt file) 270, 360
CAC2936 CAC2936 Alpha/beta superfamily hydrolase (NCBI ptt file) 236, 360
CAC3095 thiK Hydroxyethylthiazole kinase ThiM/ThiK (FS!) (NCBI ptt file) 353, 360
CAC3332 CAC3332 Predicted amidohydrolase (dihydroorothase family) (NCBI ptt file) 150, 360
CAC3356 CAC3356 Lactoylglutathione lyase (LGUL) family protein, diverged (NCBI ptt file) 236, 360
CAC3440 CAC3440 Hypothetical protein (NCBI ptt file) 353, 360
CAC3567 topB Topoisomerase B (NCBI ptt file) 66, 270
CAC3628 oppF Oligopeptide ABC transporter, ATPase component (NCBI ptt file) 270, 294
CAC3629 oppD Oligopeptide ABC transporter, ATPase component (NCBI ptt file) 270, 294
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for CAC2918
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend