Organism : Clostridium acetobutylicum | Module List :
CAC3655

Heavy-metal transporting P-type ATPase (NCBI ptt file)

CircVis
Functional Annotations (11)
Function System
Cation transport ATPase cog/ cog
copper-exporting ATPase activity go/ molecular_function
copper ion binding go/ molecular_function
ATP binding go/ molecular_function
copper ion transport go/ biological_process
metabolic process go/ biological_process
mercury ion transmembrane transporter activity go/ molecular_function
mercury ion transport go/ biological_process
integral to membrane go/ cellular_component
metal ion transmembrane transporter activity go/ molecular_function
TIGR00003 tigr/ tigrfam
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for CAC3655
(Mouseover regulator name to see its description)

CAC3655 is regulated by 19 influences and regulates 0 modules.
Regulators for CAC3655 (19)
Regulator Module Operator
CAC0189 357 tf
CAC0254 357 tf
CAC0255 357 tf
CAC0445 357 tf
CAC0977 357 tf
CAC1675 357 tf
CAC2236 357 tf
CAC2471 357 tf
CAC3429 357 tf
CAC3472 357 tf
CAC0144 108 tf
CAC2605 108 tf
CAC3271 108 tf
CAC3324 108 tf
CAC3429 108 tf
CAC3466 108 tf
CAC3472 108 tf
CAC3649 108 tf
CAC3677 108 tf

Warning: CAC3655 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
6868 1.90e-10 aGGAGg
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6869 6.30e+03 atTGgAGaAgg
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7366 2.40e-04 tGgAGGgt
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7367 2.10e+04 aGAGCG
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Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for CAC3655

CAC3655 is enriched for 11 functions in 3 categories.
Enrichment Table (11)
Function System
Cation transport ATPase cog/ cog
copper-exporting ATPase activity go/ molecular_function
copper ion binding go/ molecular_function
ATP binding go/ molecular_function
copper ion transport go/ biological_process
metabolic process go/ biological_process
mercury ion transmembrane transporter activity go/ molecular_function
mercury ion transport go/ biological_process
integral to membrane go/ cellular_component
metal ion transmembrane transporter activity go/ molecular_function
TIGR00003 tigr/ tigrfam
Module neighborhood information for CAC3655

CAC3655 has total of 37 gene neighbors in modules 108, 357
Gene neighbors (37)
Gene Common Name Description Module membership
CAC0071 CAC0071 Uncharacterized conserved protein, YTFE E.coli ortholog (NCBI ptt file) 24, 108
CAC0124 CAC0124 Hypothetical protein (NCBI ptt file) 108, 150
CAC0145 CAC0145 N-terminal Zn-ribbon domain and C-terminal MutT domain, YJAD ortholog (NCBI ptt file) 92, 108
CAC0161 CAC0161 ABC transporter (permease) (NCBI ptt file) 108, 144
CAC0295 CAC0295 Metal-dependent amidohydrolases (NCBI ptt file) 108, 190
CAC0396 CAC0396 3-hexulose-6-phosphate synthase (D-arabino-3-hexulose-6-phosphate formaldehyde lyase) (NCBI ptt file) 343, 357
CAC0428 CAC0428 Sugar permease (NCBI ptt file) 108, 145
CAC0536 dltE Short-chain dehydrodenase (gene dltE) (NCBI ptt file) 71, 108
CAC0674 CAC0674 L-serine dehydratase, alpha chain (NCBI ptt file) 19, 357
CAC0812 CAC0812 Pectate lyase related protein, secreted (NCBI ptt file) 108, 326
CAC0921 CAC0921 Metal-dependent amidohydrolase (NCBI ptt file) 24, 108
CAC1017 CAC1017 SpoVB related membrane protein (NCBI ptt file) 108, 169
CAC1071 CAC1071 Transcriptional regulator, AcrR family (NCBI ptt file) 65, 357
CAC1366 CAC1366 Predicted membrane protein (NCBI ptt file) 234, 357
CAC1492 CAC1492 Uncharacterized protein, YhhW/pirin family (NCBI ptt file) 92, 108
CAC1519 CAC1519 Predicted permease (NCBI ptt file) 253, 357
CAC1773 sacC Levanase (NCBI ptt file) 98, 357
CAC1863 CAC1863 Hypothetical protein (NCBI ptt file) 336, 357
CAC2420 CAC2420 Methyl-accepting chemotaxis protein (NCBI ptt file) 65, 357
CAC2970 PatB PLP-dependent aminotransferase, (NCBI ptt file) 337, 357
CAC2973 kdgA 2-keto-3-deoxy-6-phosphogluconate aldolase, eda/kdgA (NCBI ptt file) 108, 247
CAC2997 CAC2997 Uracil-DNA glycosylase (NCBI ptt file) 108, 230
CAC3270 CAC3270 Permease, predicted cation efflux pump (NCBI ptt file) 108, 145
CAC3380 CAC3380 Metallo-beta-lactamase superfamily hydrolase (NCBI ptt file) 108, 247
CAC3398 CAC3398 Uncharacterized conserved protein, YbhB family (NCBI ptt file) 108, 324
CAC3399 CAC3399 Predicted transcriptional regulator (NCBI ptt file) 108, 324
CAC3407 CAC3407 Acyl-CoA thioesterase 1 (NCBI ptt file) 46, 357
CAC3419 CAC3419 S-adenosylmethionine-dependent methyltransferase (NCBI ptt file) 220, 357
CAC3472 CAC3472 Protein containing transcriptional regulator domain (NCBI ptt file) 349, 357
CAC3474 CAC3474 Predicted MDR-type permease (NCBI ptt file) 108, 356
CAC3495 CAC3495 Multimeric flavodoxin WrbA family protein (NCBI ptt file) 108, 288
CAC3501 CAC3501 Predicted phosphosugar isomerase (NCBI ptt file) 108, 230
CAC3511 CAC3511 Membrane associated methyl-accepting chemotaxis protein with HAMP domain (NCBI ptt file) 210, 357
CAC3523 CAC3523 Hypothetical protein, CF-7 family (NCBI ptt file) 108, 226
CAC3649 spoVT Possible stage V sporulation protein T, transcriptional regulator AbrB homolog (NCBI ptt file) 108, 247
CAC3655 CAC3655 Heavy-metal transporting P-type ATPase (NCBI ptt file) 108, 357
CAC3677 kdpE KDP operon transcriptional regulatory protein KdpE (CheY-like receiver domain and HTH-type DNA-binding domain) (NCBI ptt file) 108, 247
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for CAC3655
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend