Environment and Gene Regulatory Influence Network (EGRIN) model for C. difficile 630

The Environment and Gene Regulatory Influence Network (EGRIN) model of C. difficile 630 was inferred using cMonkey2 and a compendium of 136 transcriptomes (retrieved from the Gene Expression Omnibus repository) with 4,070 sequence features including 35 rRNAs and 90 tRNAs . The C. difficile EGRIN model groups genes in subsets (406 modules in total), that are co-regulated in specific environments, and also identifies the associated, putative cis-acting gene regulatory elements (GREs), which represent potential TF binding locations. Transcriptome compendium included conditions: response to iron limitation, response to oxygen, in vivo vs in vitro growth, short term infection (0, 30, 60, 120 mins), response to commensals and host diet, transition from exponential to stationary phase, fur KO, codY KO, sporulation TF (and sigma factors) KOs.

Explore Regulatory Modules

Displaying 161 - 170 of 406

Candidate transcriptional regulators for each module were determined with a linear regression based approach (Inferelator) and by evaluating the statistical significance of the overlap (Hypergeometric) between modules and putative TF and alternative sigma factor regulons (CcpA, CodY, Fur, PrdR, SigB, SigD, SigE, SigF, SigG, SigH, SigK, Spo0A) compiled from available literature.

* Given that translation start was used to define the 3' end of putative promoters, some cis-regulatory motifs are likely to be ribosome binding sites (i.e., Shine-Dalgarno sequence). RBS is typically a six nucleotide sequence 5'-GGAGGA-3'.

Title	Gene Count	Motif 1 e-value	Motif 2 e-value	Residual	TF Influences
Module_391	24 CD630_36051 - Type: Gene Product:Ferredoxin \| Pathway: \| COG: Energy production and conversion CD630_13840 - Type: Gene Product:Putative lamB-like protein, UPF0271 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_13860 - Type: Gene Product:Putative allophanate hydrolase subunit 1 \| Pathway: \| COG: Amino acid transport and metabolism CD630_36080 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_10010 - Type: Gene Product:ABC-type transport system,nitrate/sulfonate/taurine ATP-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_09980 - Type: Gene Product:Putative iron-sulfur protein \| Pathway: \| COG: Energy production and conversion CD630_01340 - Type: Gene Product:Transcription antiterminator, PTS operonregulator \| Pathway: \| COG: Transcription CD630_19810 - Type: Gene Product:Transcriptional regulator, hxlR family \| Pathway: \| COG: Transcription CD630_06390 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_16750 - Type: Gene Product:Transcriptional regulator, hxlR family \| Pathway: \| COG: Transcription CD630_02780 - Type: Gene Product:Transcriptional regulator, hxlR family \| Pathway: \| COG: Transcription CD630_25060 - LinCd Type: Gene Product:Transporter, Major Facilitator Superfamily (MFS) \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_21070 - Type: Gene Product:Xanthine/uracil/thiamine/ascorbate permeasefamily protein \| Pathway: \| COG: Function unknown CD630_36060 - Type: Gene Product:Putative hydrolase \| Pathway: \| COG: Function unknown CD630_13870 - Type: Gene Product:Putative allophanate hydrolase subunit 2 \| Pathway: \| COG: Amino acid transport and metabolism CD630_13850 - Type: Gene Product:Putative natural resistance-associated macrophageprotein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_10000 - Type: Gene Product:ABC-type transport system,nitrate/sulfonate/taurine permease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_09990 - Type: Gene Product:ABC-type transport system,nitrate/sulfonate/taurine extracellular solute-bindingprotein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_24920 - Type: Gene Product:Two-component sensor histidine kinase,sporulation-associated spo0A \| Pathway: \| COG: Signal transduction mechanisms CD630_02790 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_16740 - Type: Gene Product:Putative NADPH-dependent FMN reductase \| Pathway: \| COG: Function unknown CD630_33560 - Type: Gene Product:Transcriptional regulator, hxlR family \| Pathway: \| COG: Transcription CD630_36070 - Type: Gene Product:Putative iron-sulfur assembly protein \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_25050 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription	0.00000061	0.0000024	0.48	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_01710 - rex Type: Gene Product:Transcriptional regulator, Redox-sensingrepressor Rex \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_12	20 CD630_33220 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_31880 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_15640 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_19870 - cwp28 Type: Gene Product:Putative cell wall binding protein \| Pathway: \| COG: Function unknown CD630_30050 - Type: Gene Product:Transcriptional regulator, IclR family \| Pathway: \| COG: Transcription CD630_05110 - tndX Type: Gene Product:Recombinase site-specific resolvase familyTn5397, CTn3-Orf3 \| Pathway: \| COG: Replication, recombination and repair CD630_33660 - Type: Gene Product:Putative exported protein \| Pathway: \| COG: CD630_15670 - cotG Type: Gene Product:Putative spore-associated manganese catalase \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_32680 - pstS Type: Gene Product:ABC-type transport system, phosphateextracellular solute-binding protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_17400 - Type: Gene Product:Glycine/sarcosine/betaine reductase complex,protein B, alpha and beta subunits \| Pathway: \| COG: Function unknown CD630_32480 - Type: Gene Product:Polysaccharide deacetylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_10290 - Type: Gene Product:Putative cell wall anchored protein \| Pathway: \| COG: Function unknown CD630_01640 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_19890 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_33210 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_05270 - Type: Gene Product:Putative beta-lactamase-like hydrolase \| Pathway: \| COG: Function unknown CD630_07410 - glpK1 Type: Gene Product:Glycerol kinase (GK) \| Pathway: Polyol metabolism \| COG: Energy production and conversion CD630_12400 - vanZ Type: Gene Product:Teicoplanin resistance protein \| Pathway: \| COG: Defense mechanisms CD630_32500 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_12590 - brnQ-1 Type: Gene Product:Branched chain amino acid transport systemcarrier protein \| Pathway: \| COG: Amino acid transport and metabolism	5.7e-17	`NA`	0.48	Inferelator: 4 Hypergeometric: 0 TF Influences from Inferelator CD630_10090 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_12390 - Type: Gene Product:Transcriptional regulator, beta-lactams repressorPhage-type \| Pathway: \| COG: Transcription CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms CD630_31750 - cggR Type: Gene Product:Transcriptional regulator, SorC family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_345	18 CD630_29340 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: CD630_12690 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_15910 - kdpA Type: Gene Product:Potassium-translocating ATPase A chain \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_12700 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_15930 - kdpC Type: Gene Product:Potassium-transporting ATPase C chain \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_12740 - topA Type: Gene Product:DNA topoisomerase I \| Pathway: \| COG: Replication, recombination and repair CD630_12720 - Type: Gene Product:Putative magnesium chelatase \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_36320 - Type: Gene Product:Putative isochorismatase (2,3 dihydro-2,3dihydroxybenzoate synthase) \| Pathway: \| COG: Secondary metabolites biosynthesis, transport and catabolism CD630_12760 - Type: Gene Product:Putative replication-associated recombinationprotein A RarA \| Pathway: \| COG: Replication, recombination and repair CD630_29330 - Type: Gene Product:Hypothetical protein \| Pathway: \| COG: CD630_29290 - Type: Gene Product:Putative phage protein \| Pathway: \| COG: Function unknown CD630_12750 - codY Type: Gene Product:Transcriptional regulator, GTP-sensingpleiotropic repressor \| Pathway: \| COG: Transcription CD630_29320 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_36330 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: Function unknown CD630_29300 - Type: Gene Product:Putative phage anti-repressor protein \| Pathway: \| COG: Transcription CD630_12670 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: Function unknown CD630_12780 - iscR Type: Gene Product:Transcriptional regulator, Rrf2 family \| Pathway: \| COG: Transcription CD630_29310 - Type: Gene Product:Putative phage endodeoxyribonuclease RusA-like \| Pathway: \| COG: Replication, recombination and repair	`NA`	`NA`	0.48	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_22140 - SinR Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_269	20 CD630_14090 - Type: Gene Product:Putative competence-damage inducible protein,CinA family \| Pathway: \| COG: Coenzyme transport and metabolism CD630_08760 - Type: Gene Product:ABC-type transport system, sugar-familyextracellular solute-binding protein \| Pathway: \| COG: Function unknown CD630_14080 - ddl Type: Gene Product:D-alanine--D-alanine ligase (D-alanylalaninesynthetase) (D-Ala-D-Ala ligase) \| Pathway: Cell wall biogenesis \| COG: Cell wall/membrane/envelope biogenesis CD630_14100 - Type: Gene Product:Putative hydrolase, HAD superfamily, subfamilyIIB \| Pathway: \| COG: Function unknown CD630_02170 - Type: Gene Product:Putative nitroreductase \| Pathway: \| COG: Energy production and conversion CD630_08750 - Type: Gene Product:ABC-type transport system, sugar-family permease \| Pathway: \| COG: Function unknown CD630_08730 - Type: Gene Product:ABC-type transport system sugar-familyextracellular solute-binding lipoprotein \| Pathway: \| COG: Function unknown CD630_10140 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_14070 - Type: Gene Product:Transcriptional regulator, GntR family \| Pathway: \| COG: Transcription CD630_08770 - Type: Gene Product:ABC-type transport system, sugar-familyATP-binding protein \| Pathway: \| COG: Function unknown CD630_19550 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_14060 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_14050 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Function unknown CD630_08740 - Type: Gene Product:ABC-type transport system, sugar-familyATP-binding protein \| Pathway: \| COG: Function unknown CD630_10130 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_19570 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_08780 - Type: Gene Product:ABC-type transport system, sugar-specificpermease \| Pathway: \| COG: Function unknown CD630_19560 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_17590 - Type: Gene Product:Putative SAM-dependent methyltransferase \| Pathway: \| COG: Function unknown CD630_19540 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Defense mechanisms	0.0000057	0	0.49	Inferelator: 3 Hypergeometric: 1 TF Influences from Inferelator CD630_11770 - fapR Type: Gene Product:Transcriptional regulator, DeoR family (Fattyacid and phospholipid biosynthesis regulator) \| Pathway: \| COG: Transcription CD630_19100 - eutV Type: Gene Product:Two-component response regulator, Ethanolaminespecific \| Pathway: \| COG: Signal transduction mechanisms CD630_26650 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12750 - codY Type: Gene Product:Transcriptional regulator, GTP-sensingpleiotropic repressor \| Pathway: \| COG: Transcription
Module_145	21 CD630_20900 - Type: Gene Product:Putative xanthine/uracile permease \| Pathway: \| COG: Nucleotide transport and metabolism CD630_17540 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_20870 - Type: Gene Product:Putative xanthine dehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_22590 - Type: Gene Product:Conserved hypothetical protein with RmlC-likejelly roll fold \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_17520 - Type: Gene Product:Transcriptional regulator, TetR family \| Pathway: \| COG: Transcription CD630_22580 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_20990 - XdhD Type: Gene Product:Xanthine dehydrogenase subunit XdhD,molybdopterin-binding \| Pathway: \| COG: Energy production and conversion CD630_17530 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_15610 - Type: Gene Product:Putative dehydrogenase \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_17570 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_20880 - xdhC2 Type: Gene Product:Xanthine dehydrogenase iron-sulfur bindingsubunit XdhC2 \| Pathway: \| COG: Energy production and conversion CD630_20730 - xdhA Type: Gene Product:Xanthine dehydrogenase, molybdenum bindingsubunit \| Pathway: \| COG: Energy production and conversion CD630_20890 - Type: Gene Product:Putative metal-dependent hydrolase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_17550 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_17551 - Type: Gene Product:Transcriptional regulator, HTH-type \| Pathway: \| COG: Transcription CD630_20860 - Type: Gene Product:Putative NAD(P)H-dependent FMN reductase \| Pathway: \| COG: Function unknown CD630_21000 - XdhC3 Type: Gene Product:Xanthine dehydrogenase iron-sulfur bindingsubunit XdhC3 \| Pathway: \| COG: Energy production and conversion CD630_21010 - xdhB Type: Gene Product:Xanthine dehydrogenase subunit XdhB, FAD-binding \| Pathway: \| COG: Energy production and conversion CD630_17560 - def1 Type: Gene Product:Peptide deformylase 1 (PDF 1) (Polypeptidedeformylase 1) \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_20740 - Type: Gene Product:Putative FAD-binding subunit of xanthinedehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_17580 - Type: Gene Product:Putative radical SAM superfamily protein \| Pathway: \| COG: Replication, recombination and repair	0	`NA`	0.49	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_221	19 CD630_12710 - Type: Gene Product:Putative restriction endonuclease \| Pathway: \| COG: Replication, recombination and repair CD630_12690 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_12700 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_12680 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_12740 - topA Type: Gene Product:DNA topoisomerase I \| Pathway: \| COG: Replication, recombination and repair CD630_12720 - Type: Gene Product:Putative magnesium chelatase \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_27580 - Type: Gene Product:Putative N6 adenine-specific DNAmethyltransferase, N12 class \| Pathway: \| COG: Defense mechanisms CD630_12730 - Type: Gene Product:Putative DNA processing Smf single strand bindingprotein \| Pathway: \| COG: Replication, recombination and repair CD630_12760 - Type: Gene Product:Putative replication-associated recombinationprotein A RarA \| Pathway: \| COG: Replication, recombination and repair CD630_12800 - Type: Gene Product:Putative NifU-like protein \| Pathway: \| COG: Energy production and conversion CD630_12670 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: Function unknown CD630_12770 - Type: Gene Product:Putative acetyltransferase \| Pathway: \| COG: Transcription CD630_12750 - codY Type: Gene Product:Transcriptional regulator, GTP-sensingpleiotropic repressor \| Pathway: \| COG: Transcription CD630_27570 - Type: Gene Product:Putative acyl transferase/phospholipase \| Pathway: \| COG: Function unknown CD630_12790 - iscS2 Type: Gene Product:Cysteine desulfurase \| Pathway: Cofactor biosynthesis \| COG: Amino acid transport and metabolism CD630_12660 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: Function unknown CD630_27590 - Type: Gene Product:Transcriptional regulator, Rrf2 family \| Pathway: \| COG: Transcription CD630_12780 - iscR Type: Gene Product:Transcriptional regulator, Rrf2 family \| Pathway: \| COG: Transcription CD630_27560 - ptsH Type: Gene Product:PTS system, HPr protein \| Pathway: \| COG: Carbohydrate transport and metabolism	`NA`	`NA`	0.49	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_16920 - Type: Gene Product:Transcriptional regulator, ArsR family \| Pathway: \| COG: Transcription CD630_17820 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_23900 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_397	27 CD630_10660 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_03040 - Type: Gene Product:Conserved hypothetical protein, DUF1355 family \| Pathway: \| COG: Function unknown CD630_35190 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_07610 - Type: Gene Product:Putative ATP-dependent RNA helicase \| Pathway: \| COG: Replication, recombination and repair CD630_31840 - dpaL Type: Gene Product:Diaminopropionate ammonia-lyase \| Pathway: \| COG: Amino acid transport and metabolism CD630_34620 - Type: Gene Product:Putative antitoxin EndoAI \| Pathway: \| COG: Transcription CD630_01200 - glmS Type: Gene Product:Glucosamine--fructose-6-phosphateaminotransferase [isomerizing] \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_34640 - GerS Type: Gene Product:Lipoprotein regulator, germination \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_34660 - acpS Type: Gene Product:Holo-[acyl-carrier-protein] synthase \| Pathway: \| COG: Lipid transport and metabolism CD630_03110 - GerG Type: Gene Product:Germination regulator \| Pathway: \| COG: CD630_10650 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_03030 - argE Type: Gene Product:Acetylornithine deacetylase ArgE \| Pathway: \| COG: Amino acid transport and metabolism CD630_06600 - tcdB Type: Gene Product:Toxin B \| Pathway: \| COG: Cell wall/membrane/envelope biogenesis CD630_35200 - Type: Gene Product:Putative cation efflux protein \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_31790 - pyrD Type: Gene Product:Dihydroorotate dehydrogenase, catalytic subunit \| Pathway: \| COG: Nucleotide transport and metabolism CD630_07600 - Type: Gene Product:Putative Ca2+/Na+ antiporter \| Pathway: \| COG: Inorganic ion transport and metabolism CD630_34630 - alr2 Type: Gene Product:Alanine racemase 2 \| Pathway: Amino-acid biosynthesis \| COG: Cell wall/membrane/envelope biogenesis CD630_25621 - rpmB Type: Gene Product:50S ribosomal protein L28 \| Pathway: \| COG: Translation, ribosomal structure and biogenesis CD630_31830 - Type: Gene Product:Putative peptidase, M20 family \| Pathway: \| COG: Amino acid transport and metabolism CD630_34610 - EndoA Type: Gene Product:Endoribonuclease toxin \| Pathway: \| COG: Signal transduction mechanisms CD630_31810 - Type: Gene Product:Putative amidohydrolase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_03320 - bclA1 Type: Gene Product:Exosporium glycoprotein \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport, Extracellular structures CD630_34650 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown	0.00046	0.02	0.49	Inferelator: 2 Hypergeometric: 2 TF Influences from Inferelator CD630_06290 - Type: Gene Product:Transcriptional regulator, Crp family \| Pathway: \| COG: Transcription CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test CD630_12140 - spo0A Type: Gene Product:Stage 0 sporulation protein A \| Pathway: \| COG: Signal transduction mechanisms CD630_26430 - sigE Type: Gene Product:RNA polymerase sigma-E factor \| Pathway: \| COG: Transcription
Module_36	23 CD630_20350 - Type: Gene Product:Putative sporulation integral membrane protein \| Pathway: \| COG: Function unknown CD630_24220 - Type: Gene Product:Sodium:alanine symporter \| Pathway: \| COG: Amino acid transport and metabolism CD630_18200 - ade Type: Gene Product:Adenine deaminase (Disrupted IStron) \| Pathway: \| COG: Nucleotide transport and metabolism, Nucleotide transport and metabolism CD630_20390 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_t0640 - tRNA-Met Type: Gene Product: \| Pathway: \| COG: CD630_24210 - Type: Gene Product:Putative amidohydrolase, M20D family \| Pathway: \| COG: Amino acid transport and metabolism CD630_t0150 - tRNA-Ser Type: Gene Product: \| Pathway: \| COG: CD630_t0850 - tRNA-Val Type: Gene Product: \| Pathway: \| COG: CD630_t0870 - tRNA-Lys Type: Gene Product: \| Pathway: \| COG: CD630_21151 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_20360 - Type: Gene Product:Putative peptidylarginine deiminase \| Pathway: \| COG: Amino acid transport and metabolism CD630_t0440 - tRNA-Arg Type: Gene Product: \| Pathway: \| COG: CD630_19942 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_t0560 - tRNA-Lys Type: Gene Product: \| Pathway: \| COG: CD630_20380 - Type: Gene Product:Putative drug/sodium antiporter, MATE family \| Pathway: \| COG: Defense mechanisms CD630_24200 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_t0040 - tRNA-Leu Type: Gene Product: \| Pathway: \| COG: CD630_34570 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_18910 - Type: Gene Product:Fragment of ABC-type transport system,substrate-binding protein (Part 2) \| Pathway: \| COG: Inorganic ion transport and metabolism, Inorganic ion transport and metabolism CD630_31930 - Type: Gene Product:Putative phage-related protein \| Pathway: \| COG: Function unknown CD630_31691 - secG Type: Gene Product:Protein-export membrane protein SecG \| Pathway: \| COG: Intracellular trafficking, secretion, and vesicular transport CD630_31630 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_20370 - Type: Gene Product:Putative acyl-CoA acyltransferase \| Pathway: \| COG: Function unknown	1.3e-22	2.5e-19	0.49	Inferelator: 3 Hypergeometric: 0 TF Influences from Inferelator CD630_26400 - nrdR Type: Gene Product:Transcriptional regulator, repressor NrdR family \| Pathway: \| COG: Transcription CD630_26430 - sigE Type: Gene Product:RNA polymerase sigma-E factor \| Pathway: \| COG: Transcription CD630_34990 - spoVT Type: Gene Product:Stage V sporulation protein T \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_52	14 CD630_t0230 - tRNA-Asn Type: Gene Product: \| Pathway: \| COG: CD630_15570 - Type: Gene Product:Putative peptidylprolyl isomerase \| Pathway: \| COG: Posttranslational modification, protein turnover, chaperones CD630_15600 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_15560 - Type: Gene Product:Putative polysaccharide deacetylase \| Pathway: \| COG: Carbohydrate transport and metabolism CD630_15590 - rsiV Type: Gene Product:Anti Sigma Factor, ECF family \| Pathway: \| COG: Function unknown CD630_30550 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Defense mechanisms CD630_20101 - ermC Type: Gene Product:23S rRNA methylase leader peptide \| Pathway: \| COG: CD630_12040 - xseB Type: Gene Product:Exodeoxyribonuclease VII small subunit \| Pathway: \| COG: Replication, recombination and repair CD630_11240 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: CD630_15580 - sigV Type: Gene Product:Extra-Cytoplasmic Function sigma factors, ECFfamily \| Pathway: \| COG: Transcription CD630_17620 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_15620 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_30560 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_06700 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription	0.54	`NA`	0.49	Inferelator: 1 Hypergeometric: 0 TF Influences from Inferelator CD630_06700 - Type: Gene Product:Transcriptional regulator, beta-lactamsrepressor \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`
Module_224	26 CD630_20790 - xdhA Type: Gene Product:Xanthine dehydrogenase, molybdenum bindingsubunit \| Pathway: \| COG: Energy production and conversion CD630_27340 - Type: Gene Product:Putative Na+/H+ antiporter, NhaC family \| Pathway: \| COG: Energy production and conversion CD630_31610 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: Function unknown CD630_20770 - pyrD Type: Gene Product:Dihydroorotate dehydrogenase, catalytic subunit \| Pathway: \| COG: Nucleotide transport and metabolism CD630_20820 - Type: Gene Product:Amidohydrolase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_19560 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_20800 - Type: Gene Product:Putative FAD-binding subunit of xanthinedehydrogenase \| Pathway: \| COG: Energy production and conversion CD630_19540 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Defense mechanisms CD630_16690 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_23170 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_16730 - Type: Gene Product:Conserved hypothetical protein \| Pathway: \| COG: Function unknown CD630_16710 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_31620 - Type: Gene Product:ABC-type transport system, multidrug-familyATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_20780 - Type: Gene Product:Putative S-adenosylhomocysteine deaminase \| Pathway: \| COG: Nucleotide transport and metabolism CD630_31600 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: Function unknown CD630_27330 - Type: Gene Product:Putative pyridoxal phosphate-dependenttransferase \| Pathway: \| COG: Amino acid transport and metabolism CD630_36230 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_20830 - Type: Gene Product:D-hydantoinase (Dihydropyrimidinase) \| Pathway: \| COG: Nucleotide transport and metabolism CD630_19550 - Type: Gene Product:ABC-type transport system, ATP-binding protein \| Pathway: \| COG: Defense mechanisms CD630_19570 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_20810 - xdhC1 Type: Gene Product:Xanthine dehydrogenase iron-sulfur bindingsubunit XdhC1 \| Pathway: \| COG: Energy production and conversion CD630_16680 - Type: Gene Product:Putative membrane protein \| Pathway: \| COG: CD630_23160 - Type: Gene Product:Two-component response regulator \| Pathway: \| COG: Signal transduction mechanisms CD630_16700 - Type: Gene Product:ABC-type transport system, multidrug-familypermease \| Pathway: \| COG: CD630_16720 - Type: Gene Product:Two-component sensor histidine kinase \| Pathway: \| COG: Signal transduction mechanisms CD630_36240 - Type: Gene Product:ABC-type transport system, permease \| Pathway: \| COG: Function unknown	0.17	`NA`	0.49	Inferelator: 2 Hypergeometric: 0 TF Influences from Inferelator CD630_02760 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription CD630_32140 - Type: Gene Product:Transcriptional regulator, AraC family \| Pathway: \| COG: Transcription TF Influences from Hypergeometric Test `No TF Influences from the hypergeometric test`