Organism : Campylobacter jejuni | Module List :
Regulation information for Cj0158c(Mouseover regulator name to see its description)
Motif information (de novo identified motifs for modules)
There are 4 motifs predicted.
|Motif Id||e-value||Consensus||Motif Logo|
Functional Enrichment for Cj0158c
Module neighborhood information for Cj0158c
|Gene||Common Name||Description||Module membership|
|Cj0022c||Cj0022c||putative ribosomal pseudouridine synthase (NCBI ptt file)||139, 149|
|Cj0026c||Cj0026c||hypothetical protein Cj0026c (NCBI ptt file)||50, 68|
|Cj0055c||Cj0055c||hypothetical protein Cj0055c (NCBI ptt file)||110, 149|
|Cj0061c||fliA||putative RNA polymerase sigma factor for flagellar operon (NCBI ptt file)||68, 139|
|Cj0062c||Cj0062c||putative integral membrane protein (NCBI ptt file)||116, 149|
|Cj0126c||Cj0126c||hypothetical protein Cj0126c (NCBI ptt file)||17, 68|
|Cj0156c||Cj0156c||hypothetical protein Cj0156c (NCBI ptt file)||149, 161|
|Cj0158c||Cj0158c||putative haem-binding lipoprotein (NCBI ptt file)||68, 149|
|Cj0159c||Cj0159c||hypothetical protein Cj0159c (NCBI ptt file)||141, 149|
|Cj0160c||Cj0160c||hypothetical protein Cj0160c (NCBI ptt file)||41, 149|
|Cj0164c||ubiA||putative 4-hydroxybenzoate octaprenyltransferase (NCBI ptt file)||63, 149|
|Cj0200c||Cj0200c||putative periplasmic protein (NCBI ptt file)||68, 86|
|Cj0277||Cj0277||putative periplasmic protein (NCBI ptt file)||46, 68|
|Cj0321||dxs||1-deoxyxylulose-5-phosphate synthase (NCBI ptt file)||70, 149|
|Cj0344||Cj0344||hypothetical protein Cj0344 (NCBI ptt file)||68, 121|
|Cj0364||Cj0364||hypothetical protein Cj0364 (NCBI ptt file)||49, 68|
|Cj0462||Cj0462||hypothetical protein Cj0462 (NCBI ptt file)||68, 157|
|Cj0617||Cj0617||hypothetical protein Cj0617 (617 family) (NCBI ptt file)||23, 68|
|Cj0707||kdtA||3-deoxy-D-manno-octulosonic-acid transferase (NCBI ptt file)||141, 149|
|Cj0764c||speA||biosynthetic arginine decarboxylase (NCBI ptt file)||68, 89|
|Cj0858c||murA||UDP-N-acetylglucosamine 1-carboxyvinyltransferase (NCBI ptt file)||68, 98|
|Cj1087c||Cj1087c||putative periplasmic protein (NCBI ptt file)||68, 118|
|Cj1146c||waaV||putative glucosyltransferase (NCBI ptt file)||63, 149|
|Cj1155c||Cj1155c||putative cation-transporting ATPase (NCBI ptt file)||46, 68|
|Cj1166c||Cj1166c||putative integral membrane protein (NCBI ptt file)||122, 149|
|Cj1172c||Cj1172c||hypothetical protein Cj1172c (NCBI ptt file)||68, 123|
|Cj1213c||glcD||putative glycolate oxidase subunit D (NCBI ptt file)||49, 68|
|Cj1222c||Cj1222c||putative two-component sensor (NCBI ptt file)||20, 149|
|Cj1235||Cj1235||putative periplasmic protein (NCBI ptt file)||40, 149|
|Cj1259||porA||major outer membrane protein (NCBI ptt file)||68, 121|
|Cj1261||racR||two-component regulator (NCBI ptt file)||20, 68|
|Cj1339c||flaA||flagellin (NCBI ptt file)||20, 68|
|Cj1344c||Cj1344c||putative glycoprotease (NCBI ptt file)||92, 149|
|Cj1368||Cj1368||hypothetical protein Cj1368 (NCBI ptt file)||68, 121|
|Cj1555c||Cj1555c||hypothetical protein Cj1555c (NCBI ptt file)||31, 68|
|Cj1605c||dapD||possible 2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase (NCBI ptt file)||49, 68|
|Cj1608||Cj1608||possible two-component regulator (NCBI ptt file)||149, 154|
|Cj1622||ribD||putative riboflavin-specific deaminase (NCBI ptt file)||37, 149|
|Cj1713||Cj1713||hypothetical protein Cj1713 (NCBI ptt file)||70, 149|
|Cjr06||Cjr06||5S ribosomal RNA (NCBI)||49, 68|
Gene Page Help
If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.
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Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.
If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.
You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".
For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.
Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.
Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.
Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.
Module Members Tab
Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.
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CircVisOur circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
- 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
- 2. Source gene
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