Organism : Desulfovibrio vulgaris Hildenborough | Module List :
DVU2476 gltA

oxidoreductase

CircVis
Functional Annotations (13)
Function System
NADPH-dependent glutamate synthase beta chain and related oxidoreductases cog/ cog
glutamate synthase (NADPH) activity go/ molecular_function
electron transport go/ biological_process
glutamate biosynthetic process go/ biological_process
glutamate synthase complex (NADPH) go/ cellular_component
glutamate synthase (NADH) activity go/ molecular_function
iron-sulfur cluster binding go/ molecular_function
Alanine aspartate and glutamate metabolism kegg/ kegg pathway
Nitrogen metabolism kegg/ kegg pathway
Metabolic pathways kegg/ kegg pathway
Biosynthesis of secondary metabolites kegg/ kegg pathway
Microbial metabolism in diverse environments kegg/ kegg pathway
gltA tigr/ tigrfam
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for DVU2476
(Mouseover regulator name to see its description)

DVU2476 is regulated by 20 influences and regulates 0 modules.
Regulators for DVU2476 gltA (20)
Regulator Module Operator
DVU0309
DVU0539
137 combiner
DVU0309
DVU3334
137 combiner
DVU1754
DVU2802
137 combiner
DVU2114
DVU1760
137 combiner
DVU2799 137 tf
DVU2802
DVU0539
137 combiner
DVU2960
DVU0916
137 combiner
DVUA0151
DVU3066
137 combiner
DVU0230
DVU1083
326 combiner
DVU1063 326 tf
DVU1083
DVU2832
326 combiner
DVU1754
DVU1419
326 combiner
DVU1754
DVU3334
326 combiner
DVU2785 326 tf
DVU2785
DVU0230
326 combiner
DVU2785
DVU3142
326 combiner
DVU3255
DVU0594
326 combiner
DVU3255
DVU1744
326 combiner
DVU3334
DVU2832
326 combiner
DVUA0057
DVU3066
326 combiner

Warning: DVU2476 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.
Click on the RegPredict links to explore the motif in RegPredict.

Motif Table (4)
Motif Id e-value Consensus Motif Logo RegPredict
265 4.60e+03 CCccC.cgct.T.ccaCaTtCCgc
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RegPredict
266 1.70e+03 TTTcCGaaGTcGa
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RegPredict
619 3.60e+03 aCCTCCAtga
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RegPredict
620 5.80e+03 ACCtggagcaCatcCtcat
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RegPredict
Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for DVU2476

DVU2476 is enriched for 13 functions in 3 categories.
Enrichment Table (13)
Function System
NADPH-dependent glutamate synthase beta chain and related oxidoreductases cog/ cog
glutamate synthase (NADPH) activity go/ molecular_function
electron transport go/ biological_process
glutamate biosynthetic process go/ biological_process
glutamate synthase complex (NADPH) go/ cellular_component
glutamate synthase (NADH) activity go/ molecular_function
iron-sulfur cluster binding go/ molecular_function
Alanine aspartate and glutamate metabolism kegg/ kegg pathway
Nitrogen metabolism kegg/ kegg pathway
Metabolic pathways kegg/ kegg pathway
Biosynthesis of secondary metabolites kegg/ kegg pathway
Microbial metabolism in diverse environments kegg/ kegg pathway
gltA tigr/ tigrfam
Module neighborhood information for DVU2476

DVU2476 has total of 42 gene neighbors in modules 137, 326
Gene neighbors (42)
Gene Common Name Description Module membership
DVU0090 wcaG GDP-fucose synthetase 137, 236
DVU0108 hypothetical protein DVU0108 137, 311
DVU0143 hypothetical protein DVU0143 95, 137
DVU0306 hypothetical protein DVU0306 320, 326
DVU0333 hypothetical protein DVU0333 65, 137
DVU0376 hypothetical protein DVU0376 137, 305
DVU0378 thioredoxin 137, 236
DVU0488 purD phosphoribosylamine--glycine ligase 193, 326
DVU0842 hypothetical protein DVU0842 52, 137
DVU0843 hypothetical protein DVU0843 23, 137
DVU1034 hypothetical protein DVU1034 202, 326
DVU1096 argF ornithine carbamoyltransferase 137, 208
DVU1226 hypothetical protein DVU1226 224, 326
DVU1297 hypothetical protein DVU1297 202, 326
DVU1400 methyl-accepting chemotaxis protein 283, 326
DVU1455 hypothetical protein DVU1455 137, 188
DVU1610 nadE glutamine-dependent NAD+ synthetase 166, 326
DVU1728 hypothetical protein DVU1728 137, 315
DVU1770 hydB periplasmic 137, 294
DVU1846 pgsA CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 123, 326
DVU1885 gatB aspartyl/glutamyl-tRNA amidotransferase subunit B 202, 326
DVU1956 heptosyltransferase family protein 137, 261
DVU1981 nucleotide-binding protein 84, 326
DVU2025 hypothetical protein DVU2025 273, 326
DVU2063 hypothetical protein DVU2063 137, 208
DVU2149 hypothetical protein DVU2149 32, 326
DVU2237 cobalamin biosynthesis protein CobD 84, 326
DVU2331 Smr family protein 137, 291
DVU2370 outer membrane protein OmpH 81, 137
DVU2476 gltA oxidoreductase 137, 326
DVU2628 hypothetical protein 234, 326
DVU2656 hypothetical protein DVU2656 326, 329
DVU2667 phosphate ABC transporter periplasmic phosphate-binding protein 119, 137
DVU2694 hypothetical protein DVU2694 137, 289
DVU2753 hypothetical protein 97, 326
DVU2764 nitroreductase family protein 27, 137
DVU2773 hypothetical protein DVU2773 242, 326
DVU2939 hypothetical protein DVU2939 97, 326
DVU2946 hypothetical protein DVU2946 137, 230
DVU3035 methyl-accepting chemotaxis protein 137, 229
DVU3159 gpsA NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 137, 258
DVU3162 ABC transporter periplasmic substrate-binding protein 137, 193
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for DVU2476
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Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend