Organism : Geobacter sulfurreducens | Module List :
GSU2507

sensor histidine kinase (NCBI)

CircVis
Functional Annotations (6)
Function System
Signal transduction histidine kinase regulating C4-dicarboxylate transport system cog/ cog
two-component sensor activity go/ molecular_function
ATP binding go/ molecular_function
signal transduction go/ biological_process
membrane go/ cellular_component
peptidyl-histidine phosphorylation go/ biological_process
GeneModule member RegulatorRegulator MotifMotif

Cytoscape Web
Regulation information for GSU2507
(Mouseover regulator name to see its description)

GSU2507 is regulated by 18 influences and regulates 0 modules.
Regulators for GSU2507 (18)
Regulator Module Operator
GSU0366 341 tf
GSU0598 341 tf
GSU0655 341 tf
GSU1072 341 tf
GSU1250 341 tf
GSU1268 341 tf
GSU1934 341 tf
GSU2041 341 tf
GSU2506 341 tf
GSU2670 341 tf
GSU2741 341 tf
GSU2987 341 tf
GSU0682 299 tf
GSU1410 299 tf
GSU1626 299 tf
GSU2362 299 tf
GSU2753 299 tf
GSU3387 299 tf

Warning: GSU2507 Does not regulate any modules!

Motif information (de novo identified motifs for modules)

There are 4 motifs predicted.

Motif Table (4)
Motif Id e-value Consensus Motif Logo
2756 2.90e+03 AaTCaAtGtAtTA
Loader icon
2757 8.50e+03 AAAATgGtaTG
Loader icon
2836 2.70e+00 CAaAtgatGatAATCA
Loader icon
2837 5.70e-01 CaGAgccacgTgAttaataAACaA
Loader icon
Motif Help

Transcription factor binding motifs help to elucidate regulatory mechanism. cMonkey integrates powerful de novo motif detection to identify conditionally co-regulated sets of genes. De novo predicted motifs for each module are listed in the module page as motif logo images along with associated prediction statistics (e-values). The main module page also shows the location of these motifs within the upstream sequences of the module member genes.

Motifs of interest can be broadcasted to RegPredict (currently only available for Desulfovibrio vulgaris Hildenborough) in order to compare conservation in similar species. This integrated motif prediction and comparative analysis provides an additional checkpoint for regulatory motif prediction confidence.

Motif e-value: cMonkey tries to identify two motifs per modules in the upstream sequences of the module member genes. Motif e-value is an indicative of the motif co-occurences between the members of the module.Smaller e-values are indicative of significant sequence motifs. Our experience showed that e-values smaller than 10 are generally indicative of significant motifs.

Functional Enrichment for GSU2507

GSU2507 is enriched for 6 functions in 3 categories.
Enrichment Table (6)
Function System
Signal transduction histidine kinase regulating C4-dicarboxylate transport system cog/ cog
two-component sensor activity go/ molecular_function
ATP binding go/ molecular_function
signal transduction go/ biological_process
membrane go/ cellular_component
peptidyl-histidine phosphorylation go/ biological_process
Module neighborhood information for GSU2507

GSU2507 has total of 35 gene neighbors in modules 299, 341
Gene neighbors (35)
Gene Common Name Description Module membership
GSU0100 GSU0100 hypothetical protein (VIMSS) 88, 299
GSU0641 GSU0641 hypothetical protein (VIMSS) 13, 299
GSU0682 GSU0682 DNA-binding response regulator, LuxR family (VIMSS) 275, 299
GSU0789 GSU0789 response regulator (VIMSS) 187, 299
GSU0984 GSU0984 hypothetical protein (VIMSS) 13, 299
GSU1060 GSU1060 hypothetical protein (VIMSS) 269, 341
GSU1153 GSU1153 outer membrane protein, OMP85 family (NCBI) 275, 299
GSU1301 cheW-5 purine-binding chemotaxis protein CheW (NCBI) 212, 299
GSU1331 GSU1331 efflux transporter, RND family, MFP subunit (NCBI) 165, 341
GSU1332 GSU1332 heavy metal efflux pump, CzcA family (VIMSS) 46, 341
GSU1338 GSU1338 heavy-metal-associated domain protein (VIMSS) 13, 299
GSU1339 GSU1339 hypothetical protein (NCBI) 206, 341
GSU1340 GSU1340 ABC transporter, permease protein (VIMSS) 206, 341
GSU1341 GSU1341 ABC transporter, ATP-binding protein (VIMSS) 184, 341
GSU1355 GSU1355 ISGsu7, transposase OrfA (VIMSS) 335, 341
GSU1361 GSU1361 Piwi domain protein (NCBI) 212, 299
GSU1508 GSU1508 conserved hypothetical protein (VIMSS) 124, 299
GSU1776 GSU1776 pilin domain protein (VIMSS) 245, 299
GSU2457 GSU2457 conserved hypothetical protein (NCBI) 13, 299
GSU2493 GSU2493 NHL repeat domain protein (NCBI) 9, 341
GSU2497 GSU2497 lipoprotein, putative (VIMSS) 206, 341
GSU2498 GSU2498 lipoprotein, putative (VIMSS) 206, 341
GSU2499 GSU2499 hypothetical protein (VIMSS) 66, 341
GSU2501 GSU2501 cytochrome c family protein (NCBI) 66, 341
GSU2502 GSU2502 spermine/spermidine synthase family protein (VIMSS) 141, 341
GSU2505 GSU2505 NHL repeat domain protein (VIMSS) 66, 341
GSU2506 GSU2506 sensory box protein/sigma-54 dependent DNA-binding response regulator (NCBI) 97, 341
GSU2507 GSU2507 sensor histidine kinase (NCBI) 299, 341
GSU2508 GSU2508 TPR domain protein (NCBI) 6, 341
GSU2747 GSU2747 hypothetical protein (VIMSS) 110, 341
GSU2810 GSU2810 hypothetical protein (VIMSS) 13, 299
GSU3204 GSU3204 conserved hypothetical protein (VIMSS) 212, 299
GSU3438 GSU3438 conserved hypothetical protein (VIMSS) 187, 299
GSU3439 GSU3439 NADH dehydrogenase I, G subunit (VIMSS) 167, 299
GSU3445 nuoA-2 NADH dehydrogenase I, A subunit (NCBI) 119, 299
Gene Page Help

Network Tab

If the gene is associated with a module(s), its connection to given modules along with other members of that module are shown as network by using CytoscapeWeb. In this view, each green colored circular nodes represent module member genes, purple colored diamonds represent module motifs and red triangles represent regulators. Each node is connected to module (Bicluster) via edges. This representation provides quick overview of all genes, regulators and motifs for modules. It also allows one to see shared genes/motifs/regulators among diferent modules.

Network representation is interactive. You can zoom in/out and move nodes/edges around. Clicking on a node will open up a window to give more details. For genes, Locus tag, organism, genomic coordinates, NCBI gene ID, whether it is transcription factor or not and any associated functional information will be shown. For regulators, number of modules are shown in addition to gene details. For motifs, e-value, consensus sequence and sequence logo will be shown. For modules, expression profile plot, motif information, functional associations and motif locations for each member of the module will be shown.
You can pin information boxes by using button in the box title and open up additional ones on the same screen for comparative analysis.

Regulation Tab

Regulation tab for each gene includes regulatory influences such as environmental factors or transcription factors or their combinations identified by regulatory network inference algorithms.

If the gene is a member of a module, regulators influencing that module are also considered to regulate the gene. Regulators table list total number of regulatory influences, regulators, modules and type of the influence.

You can see description of the regulator inside the tooltip when you mouseover. In certain cases the regulatory influence is predicted to be the result of the combination of two influences. These are indicated as combiner in the column labeled "Operator".

For transcription factors, an additional table next to regulator table will be show. This table show modules that are influenced by the transcription factor.

Motifs Tab

Network inference algorithm uses de novo motif prediction for assigning genes to modules. If there are any motifs identified in the upstream region of a gene, the motif will be shown here. For each motif sequence logo, consensus and e-value will be shown.

Functions Tab

Identification of functional enrichment for the module members is important in associating predicted motifs and regulatory influences with pathways. As described above, the network inference pipeline includes a functional enrichment module by which hypergeometric p-values are used to identify over representation of functional ontology terms among module members.

Network Portal presents functional ontologies from KEGG, GO, TIGRFAM, and COG as separate tables that include function name, type, corrected and uncorrected hypergeometric p-values, and the number of genes assigned to this category out of total number of genes in the module.

Module Members Tab

Identity of gene members in a module may help to identify potential interactions between different functional modules. Therefore, neighbor genes that share the same module(s) with gene under consideration are shown here. For each memebr, gene name, description and modules that contain it are listed.

Help Tab

This help page. More general help can be accessed by clicking help menu in the main navigation bar.

Social Tab

Network Portal is designed to promote collaboration through social interactions. Therefore interested researchers can share information, questions and updates for a particular gene.

Users can use their Disqus, Facebook, Twitter or Google accounts to connect to this page (We recommend Google). Each module and gene page includes comments tab that lists history of the interactions for that gene. You can browse the history, make updates, raise questions and share these activities with social web.

In the next releases of the network portal, we are planning to create personal space for each user where you can share you space that contains all the analysis steps you did along with relevant information.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend
Comments for GSU2507
Please add your comments for this gene by using the form below. Your comments will be publicly available.

comments powered by Disqus

Gene Help

Overview

Gene landing pages present genomic, functional, and regulatory information for individual genes. A circular visualization displays connections between the selected gene and genes in the same modules, with as edges drawn between the respective coordinates of the whole genome.

The gene page also lists functional ontology assignments, module membership, and motifs associated with these modules. Genes in the network inherit regulatory influences from the modules to which they belong. Therefore, the regulatory information for each gene is a collection of all regulatory influences on these modules. These are listed as a table that includes influence name, type, and target module. If the gene is a transcription factor, its target modules are also displayed in a table that provides residual values and number of genes.

CircVis

Our circular module explorer is adapted from visquick originally developed by Dick Kreisberg of Ilya Shmulevich lab at ISB for The Cancer Genome Atlas. We use simplified version of visquick to display distribution of module members and their interactions across the genome. This view provides summary of regulation information for a gene. The main components are;
  • 1. All genomic elements for the organism are represented as a circle and each element is separated by black tick marks. In this example chromosome and pDV represent main chromosome and plasmid for D. vulgaris Hildenborough, respectively.
  • 2. Source gene
  • 3. Target genes (other module members)
  • 4. Interactions between source and target genes for a particular module
  • 5. Module(s) that source gene and target genes belong to
  • 6. Visualisation legend