Rv0057

Summary
Product Feature Type Start End Strand Length AA Length is TF
Rv0057 CDS 59896 60417 + 522 173 FALSE

Rv0057 () is predicted to be co-regulated in modules bicluster_0365 with residual 0.53 and bicluster_0523 with residual 0.52.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 8,900.00 for bicluster_0365 and 0.08 and 2,900.00 for bicluster_0523 respectively.

These modules are enriched for following go terms: phosphopantetheine binding, modified amino acid binding, cofactor binding, amide binding, amino acid binding.

This gene is found to be for growth on cholesterol.

Mutant available?:

Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 10 of 21
ChipSeq TF Differential Expression Distance Expression pvalue Type
Organic hydroperoxide resistance transcriptional regulator
No -134 0.5 0.0807394 Internal.TSS
DNA-binding response regulator
No -90 -0.38 0.0700584 Internal.TSS
Organic hydroperoxide resistance transcriptional regulator
No -74 0.5 0.0807394 Internal.TSS
Transcriptional regulator, TetR family
No -18 -0.52 0.0576808 CDS
Transcriptional regulator, TetR family
No 26 -0.07 0.865588 Internal.TSS
Transcriptional regulator, ArsR family
No -71 0.14 0.453665 Internal.TSS
Transcriptional regulatory protein
Induced -140 1.04 0.000000121 Internal.TSS
transcriptional regulator, ArsR family
No 56 0.55 0.000112543 Internal.TSS
No -136 0.27 0.282314 Internal.TSS
No -76 0.27 0.282314 Internal.TSS
Motif 1 Motif 2 Residual
bicluster_0365
e.value: 
0.0049
Motif Bicluster: 
e.value: 
8900
Motif Bicluster: 
0.53
bicluster_0523
e.value: 
0.083
Motif Bicluster: 
e.value: 
2900
Motif Bicluster: 
0.52
Product (LegacyBRC) Product (RefSeq)
Uncharacterized protein Rv0057_MT0063
Operon # Operon
37 - - -
PATRIC Locus Tag Enzyme Name Transcriptomics
NA
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.590000 1.84

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: