Rv0203 POSSIBLE EXPORTED PROTEIN

Summary
Product Feature Type Start End Strand Length AA Length is TF
Rv0203 POSSIBLE EXPORTED PROTEIN CDS 241514 241924 + 411 136 FALSE

Rv0203 (POSSIBLE EXPORTED PROTEIN) is predicted to be co-regulated in modules bicluster_0301 with residual 0.61 and bicluster_0504 with residual 0.56.

This regulation is possibly mediated by two de-novo identified cis-regulatory motifs in each module with e-values , 0.00 and 4.40 for bicluster_0301 and 0.00 and 3.10 for bicluster_0504 respectively.

These modules are enriched for following go terms: divalent metal ion transport, divalent inorganic cation transport, transition metal ion transport, divalent inorganic cation transmembrane ... nitrogen cycle metabolic process, transition metal ion binding, hydrolase activity, acting on carbon-nit..., metal ion binding.

This gene is found to be for growth on cholesterol.

Mutant available?:

Displaying 1 - 1 of 1
Gene Target Differential Expression Distance Expression pvalue Type
No results were found
Displaying 1 - 3 of 3
ChipSeq TF Differential Expression Distance Expression pvalue Type
TetR/ACRR family transcriptional regulator
No 0 0.07 0.990324 CDS
DNA-binding response regulator TrcR
No -48 0.2 0.768052 CDS
No 5 0.16 0.837771 CDS
Motif 1 Motif 2 Residual
bicluster_0301
e.value: 
0.00091
Motif Bicluster: 
e.value: 
4.4
Motif Bicluster: 
0.61
bicluster_0504
e.value: 
0.0025
Motif Bicluster: 
e.value: 
3.1
Motif Bicluster: 
0.56
Product (LegacyBRC) Product (RefSeq)
POSSIBLE EXPORTED PROTEIN [Putative uncharacterized protein]
Operon # Operon
140
PATRIC Locus Tag Enzyme Name PATRIC Pathways Transcriptomics

PATRIC

Not assigned Not assigned
Locus Tuberculist Genome View

Tuberculist

Quickview
Locus Tag KEGG Pathways

KEGG

not assigned to any KEGG Pathway.
BioCyc Gene Page Cellular Overview Map
Link to STRING STRING Network

STRING

GI Number Protein ID Blast Conserved Domains
15607344 NP_214717.1 Run
GO:0005576

extracellular region

extracellular region

Details: 
The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite.
GO Category: 
cellular_component
272
Total items in this category:  
Description:Expression data from transcription factor over expression experiments. TFOE are matched to the ChIP-seq experiment done simultaneously. This dataset is described in Rustad et al. 2014, Genome Biology.
Quantitative Proteomics Data
t-test p-value Cholesterol/Glycerol Ratio
0.720000 1.06

How essentiality calculations were done?

The relative representation of each mutant was determined by calculating the fold change (sequence reads/insertion in cholesterol divided by sequence reads/insertion in glycerol) for each gene. Statistical significance was determined by t-test. Each insertion site in each replicate sample was treated as a separate data point. The hyperbola used for defining genes specifically required for growth in cholesterol was defined by the formula, y = 3.8/x+0.7. Genes above this line are annotated as required for growth on cholesterol.

TRIP log2 fold abundance change

reports the log2 abundance fold change of each TFI strain, relative to no induction, in absence or presence of drug, averaged across experimental replicates. Also reported are the accompanying z-scores and two-sided t-test p-values for each TFI strain under each condition. Please refer to Ma et al., 2020, Nature Microbiology for more information.

p-value Untreated:
p-value INH: